Simone Ecker

Medical Genomics @uclcancer.
Computational biology, epigenomics, transcriptomics, immune cells.
Passion for science. Loves nature, traveling & photography.

[Andres Cardenas @cardenaasca]

#EWAS of smoking and #epigenetic #age acceleration among Costa Rican adults. Former smokers had consistent age acceleration and we replicated smoking related hits in Latine pop @drehkopf @SimoneEcker @r_fadadu @khnorthcote @lmcewen @GladishNicole @koborlab https://t.co/W2cB3wdt5M

[Nature Cancer @NatureCancer]

⭐️ONLINE NOW @NatureCancer: "#Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic #leukemia" by @TuratiVirginia @tariqenver &Co @UCL

Find it here!👇
https://t.co/0mF4Gz8mly
https://t.co/VMRc5DUpcg

#CancerTherapy #Chemoresistance

[Michael Hubank @generoom]

@TuratiVirginia @JavierHerrero7 @VanLooLab @SimoneEcker @AfonsoHenriques @ChulingD And what a journey! An extraordinarily thorough and painstaking investigation showing that treatment induced selection in B-ALL acts on #epigenetic, not genetic states.
Utmost respect for @TuratiVirginia.
#Cancer

[Virginia Turati @TuratiVirginia]

Stoked to see our paper out today in @NatureCancer! Epigenetic cell state, not genetic variegation, is the principal substrate for bottleneck selection during induction chemotherapy in childhood BCP-ALL. Check it out here https://t.co/gQT8ayGItX
@uclcancer

[Genome Biology @GenomeBiology]

GOmeth and GOregion are gene set enrichment methods for DNA methylation data from @JovMaksimovic, @AliciaOshlack & @BelindaPhipson. It takes into account the fact that CpGs on chips are unevenly distributed between genes, &and some CpGs linked to >1 gene https://t.co/rkyVgAQhEu

[Ariel Gershman @GershmanAriel]

So excited to announce our preprint “Epigenetic Patterns in a Complete Human Genome” where we generate the most complete human epigenome analysis to date and uncover novel insights into human centromere epigenetic regulation. A few highlights: https://t.co/oU7TGenprM

[Tuuli Lappalainen @tuuliel]

A big day for human genomics!

It's also very cool that this is released as a preprint.

[Lonni Besançon 🇫🇷 🇸🇪 @lonnibesancon]

Our open letter about academic whistleblowers like
@MicrobiomDigest is mentioned in @guardian by @MelissaLDavey

You can find the letter here: https://t.co/4PIsRTFZtu
Scientists co-sign it here: https://t.co/BCmWuJdmev…

The article is here https://t.co/eiwUCbs6M5

[Simone Ecker @SimoneEcker]

@ChrissieThirlw1 @SWGLH @NHSgms Fantastic news, Chrissie! Huge congratulations 👏🥳

[Petter Brodin @BrodinPetter]

Human immune systems can only be understood by studying diverse human populations. In @naturemethods we call for more inclusive human immunology research https://t.co/m8JVayXxBO

[João Pedro de Magalhães @jpsenescence]

Wow, another amazing epigenetic clock study by Steve Horvath et al.

They find that methylation levels, set at birth, predict maximum lifespan in mammals. Genes proximal to methylation sites tend to be associated with development, metabolism.

https://t.co/djBa2linf4

[Gabriele Pollara @gpollara]

1/11 Thrilled to FINALLY share:

🚨 Elevated in vivo IL-17A activity in human active #TB vs latent/cured TB 🚨

Supports targeting this cytokine axis to reduce disease pathology & transmission. #tuberculosis

Paper @ScienceTM: https://t.co/msL5MGeCK7
Explainer thread:👇

[Mikhail Spivakov @mikhailspivakov]

Using inter-individual variation in TF binding and its downstream effects in primary neutrophils as "nature's perturbation experiment" to interpret the function of immune GWAS SNPs.

Our joint work with @nicolesoranzo's team,
@BiolaMJavierre, @Ciavenasc

https://t.co/4TtAYIWvli

[@qmulepigenetics @QMULepigenetics]

Hope you had a good break & Happy 2021! We are back with more weekly webinars! The first one is by Stephan Beck UCL. Stephan will be speaking on "Connecting Dots for Genomics Medicine" next Tuesday, 12th of Jan at 16.30 GMT join us with the link👉 https://t.co/CbmwrgU7Fe pl share

[Manuel Corpas @manuelcorpas]

.@wellcomegenome #PersonalGenomics event w/ stellar keynotes @23andMe @joannamtn & @Stanford @SnyderShot among many other world renown scientists.

Privileged to form part of the organising committee for such an amazing #international #conference.

[PGP-UK @PGPUK_genomes]

Many congratulations to @AfonsoHenriques, @Ismail_Moghul, @awebster90, @SimoneEcker, @JavierHerrero7, @StephanBeck6 and all the PGP-UK team @PGPUK_genomes on the publication of GenomeChronicler just out in Fontiers in Genetics!

https://t.co/R7DF6PUjjd

[Simone Ecker @SimoneEcker]

@ChrissieThirlw1 @EllardSian @awebster90 @simonag56739514 @GraceEScience @SallieLamb18 @InesBarroso4 @njervis67 @FCLynnette @Dr_VMosienko @carolinerelton Thank you @ChrissieThirlw1!
Same to you! 🙂

[Nature Aging @NatureAging]

Launching in January 2021 and now open for submissions, Nature Aging will publish research from across the basic biology of aging, geriatrics, and gerontology to the impact of aging on society. Visit us online to learn more, register for E-Alerts from launch, and submit research.

[PGP-UK @PGPUK_genomes]

PGP-UK Health Assessment in support of COVID-19 related research.

A Big Thank to our participants who proved themselves again as valuable Citizen Scientists by taking part in the Assessment.

https://t.co/CrRXvkIGPd

[Simone Ecker @SimoneEcker]

On Steve Horvath's exciting new preprint claiming to *reverse* the (epigenetic) age of rats by 54%
https://t.co/Avt0kt8DVZ

[David Sinclair @davidasinclair]

Finally had time to carefully read the new preprint that claims to reverse the age of rats by 54%. I spoke to the first author & in this thread ask whether the results are believable and what if it is true? https://t.co/Odcd24slwe 1/n