Prof. Vishal Rai (IISER Bhopal) delivered an insightful lecture at the 3rd International NOST Conference on "Organic Chemistry with Proteins: in vitro, in live cells, and in vivo."
The talk highlighted innovative chemical approaches for studying and manipulating proteins across diverse biological environments, bridging the interface of organic chemistry and chemical biology.
#NOST2026 #NOSTIndia #ChemicalBiology #OrganicChemistry #ChemicalSciences #IISERBhopal
Our latest review has been published in Synlett @synlett_journal !
“Sulfur-containing Salt-based Organophotoredox Catalysis”
Congratulations Atsuya (@atsuya39124), Masato (@masatonnn777), Yuta (@YutaGoto1557196)!
https://t.co/L4JDSKMnNm
Optical regulation of glutathione S-transferase using an Azo-labeling strategy and assessment of enzyme activity using a specific fluorescent probe
https://t.co/nlimcxNNcs
A new tridentate NHC ligand for photoactive first-row transition metal complexes and its Fe(III) complex now out in @J_A_C_S done by our Master's student Toshiki! https://t.co/Kr2H3FZml0
Answers: A and 2. Pamidronate is an IV bisphosphonate derivative for osteolytic bone metastases of breast cancer or multiple myeloma, hypercalcemia of malignancy, and Paget’s disease. Musculoskeletal pain, femur fractures, ONJ, and myelosuppression are possible.
Atropine + Pralidoxime.
✓ It is the standard antidote combination for organophosphate poisoning.
∆ Mechanism- Organophosphates irreversibly inhibit acetylcholinesterase→ acetylcholine excess → cholinergic crisis (DUMBBELSS: Diarrhea, Urination, Miosis, Bradycardia, Bronchorrhea, Emesis, Lacrimation, Salivation, Seizures).
∆ Reason for this combination-:
Atropine: It is an Muscarinic antagonist→ dries secretions, increases Heart Rate, relieves bronchospasm (titrate to clear chest, dry skin).
Pralidoxime- It Reactivates AChE by cleaving phosphate bond before enzyme aging (give within 24-48hrs).
@Looping83_2@EarekaDK@Anti5GWarrior@Arreter_Fischer Good job guys. There's a lot to understand in how porphyrin structures in heme and chlorophyll..help our unity w geomagnetism and chemistry. Nature appears to bind strong and weak forces in