Skylar Kitchen @skylartkitchen - Twitter Profile

Today, in collaboration with Anthropic, we’re excited to share rapid initial progress towards an antibody treatment for food allergy, which affects over 200 million people worldwide, discovered with the help of Claude. At Divergence Labs, we believe that AI can unlock the next generation of antibody therapeutics with more effective mechanisms than before. Such mechanisms are urgently needed in food allergy, which involve overcoming one of the tightest affinity protein pairs in immunology, IgE and its receptor FcεRI, on mast cells. Treatment with Xolair—the only approved antibody for food allergy—sequesters circulating IgE, but mast cells remain sensitized for weeks to months due to the extraordinarily slow dissociation of IgE from FcεRI. We envision a treatment that actively pulls IgE off of FcεRI, without waiting for natural dissociation. Like picking a lock, this requires the right combination of geometry and force. Our research team, working with Claude, ideated on mechanisms to accomplish this disruption, and converged on an antibody format with two arms with different functions and epitopes. Within one month, we designed, synthesized, and experimentally confirmed the biophysical function of the two arms, which we are now assembling into full therapeutic formats.

133

5K

633

2K

504K

Skylartkitchen retweeted

Anthropic

@AnthropicAI

4 days ago

Over the past few months, Anthropic scientists have engaged in deep research partnerships with six organizations developing new medicines. We've also begun drug discovery efforts of our own. In doing so, we’ve learned much more about how Claude can support the many stages of drug development. In this blog post, we share some early results from these efforts, and describe how this work fits in with our wider ambitions in the life sciences. https://t.co/EVbxkdDTgJ

771

12K

1K

4K

4M

Skylar Kitchen @Skylartkitchen

5 days ago

@JasnDavid Idk why that would be true

0

31

Skylar Kitchen @Skylartkitchen

5 days ago

@bryanmanio @webflow Sad to see :(

1

0

19

Skylartkitchen retweeted

Peter Yang

@petergyang

5 days ago

I love that two of the main AI benefits @AnthropicAI highlights in its S-1 are curing diseases and getting treatment to more people. 1) Curing diseases "AI will profoundly accelerate the rate of progress in biology and medicine, potentially curing diseases that have plagued humanity for millennia, including cancer, Alzheimer's disease, heart disease, rare genetic diseases, and the major infectious diseases." 2) Getting treatment to more people "Today, even when medicines for terrible diseases are developed, they do not always reach everyone who needs them... An estimated 4.6 billion people, more than half the world's population, still lack access to essential health services." Caring for my mom, I've seen how much of healthcare is waiting, paperwork, and chasing the right answer from the right person. I genuinely think the biggest benefit AI can bring to humanity is advancing medicine and cutting bureaucracy so patients and caregivers around the world can get the best care.