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I clear up misinformation all over Twitter

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@SouthON_KCCO @GovCanHealth There are different kinds of antibodies that protect you (not talking about classification like IgG, IgM, etc): protective antibodies and neutralizing antibodies. Protective antibodies help by aiding white blood cells to the pathogen, activate complement system, etc

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@Biff234523 That will of course boost mucousal response for flu*

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@Biff234523 Ah sorry I mean upper respiratory system. The idea being you are getting Flumist so that will of course boost mucousal response but also by getting the Covid shot it will bring some of those cells there (as an alternative to neonycin perhaps)

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@Biff234523 What about Nuvaxovid + Flumist to also ensure some of the immune cells end up in the lungs?

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@Tabsjourney His so-called advice killed @AnnadeBuisseret

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@goobury @COVID19_disease Clean air won't help against HSV

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@JeremyYongpeng @alexboge I already explained to you that there would be plenty of binding antibodies. You are mixing up neutralizing antibodies. Regardless, we are going in circles. No point in continuing this conversation

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@JeremyYongpeng @alexboge And I see you have no response to the lack of serology either

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@JeremyYongpeng @alexboge I see coping here. Metagenomics picks up everything

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@JeremyYongpeng @alexboge was discovered with metagenomics when all the existing viral tests were negative and so metagenomics were used).

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@JeremyYongpeng @alexboge And again, your argument doesn't hold water. Like I said, when SARS emerged, we became aware of it. No serology to support it in the general population and metagenomics could label any sequence of sarbecoviruses discovered since. And it took until SARS-CoV-2 (which also

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@JeremyYongpeng @alexboge Also how do you think rhinovirus C was discovered? 😉

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@JeremyYongpeng @alexboge Like I mentioned earlier WGS and metagenomics became commercially available in the early 2000s. We have no evidence of any human sarbecoviruses through such sequencing nor serology supporting your claim.

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@JeremyYongpeng @alexboge *As an aside, non-neutralizing antibodies can still help due to Fc receptors on immune cells and we have T Cells as well. Anyways, that we had circulating human sarbecoviruses is a silly hill to die on

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@JeremyYongpeng @alexboge Neutralizing antibodies are a subset of all the binding antibodies. These can block a virus from infecting the cell*. You don't need those in serology to test if someone has been exposed to that or similar viruses. In fact, that is significant more work than just testing binding

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@JeremyYongpeng @alexboge You don't test neutralizing antibodies to detect if people have been exposed to sarbecoviruses. And in fact, those who have had SARS-CoV had antibodies binding to SARS-CoV-2. And again, WGS picks up everything (as an example novel entroviruses we haven't seen before)

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@dr_jon_l @jeffreytucker Yup! Had there been an increase, the studies would have shown that.

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@JeremyYongpeng @alexboge You do know that serologic data would have shown that since SARS emerged in 2003? And it didn't. In addition, there's a lot of WGS happening in wastewater which would have caught these supposed other human sarbecoviruses too

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@JeremyYongpeng @jackunheard So physicians and immunologists have no background in biology? 🤡