same case also had other areas showing giant cell subtype urothelial carcinoma
👿aggressive behavior
✔️DDx: trophoblastic differentiation, osteoclast-rich urothelial carcinoma (currently falls under poorly diff subtype)
👀great recent study by @Andres_Matoso
PMID: 42252958
#GUpath lymphoepithelioma-like subtype urothelial carcinoma:
🔬syncytial growth+admixed inflammation
💊may show favorable Px (esp when pure) & respond to chemo
🚫related to EBV virus
🧪shows basal-like molecular phenotype
✔️DDx: lymphoma, small cell ca, b9 inflammation
#publicationalert#gupath
In this multi-institutional study of 51 EVTs, CD56 was positive in 98% of cases, supporting its utility as an adjunct diagnostic marker.
Thank you to the @patholojenMD and @slusagar for including me in this collaborative effort!
wondering what's up with this "artifact" from a wholemount radical prostatectomy?
the answer lies in the grossing, not the processing!
#GUpath#surgpath
"applique" appearance testicular embryonal carcinoma
▶️smudgy, degen-appearing tumor cells "applied" to tumor periphery
▶️1st described in 1946 (PMID: 20276801)
▶️more commonly seen in EC, infreq in seminoma, YS
▶️degen cells mimic of syncytiotrophoblasts but CD30+ hCG-
#GUpath
✔️uncommon pattern of pTa PUC
✔️ecad IHC retained
✔️shows dz progression more akin to high grade than low grade
✔️okay to😍🔬 but given non-invasive probably better to not document as "plasmacytoid" in report to avoid confusion with INVASIVE version (not nec a precursor)
you get a #GUpath TURBT pTa papillary urothelial carcinoma, with these striking "plasmacytoid" looking foci but no invasion
in 2-tier grading: low vs high🤨⁉️
@KukMariya and I recently explored this in a series
PMID: 42517751