garth slysz

servant of Jesus Christ,husband, father,physician, Hospitalist

[X Freeze @XFreeze]

This might be the most important video you watch this Easter Sunday

An atheist doctor's journey to Christ

[garth slysz @slysz]

I'm claiming my AI agent "Radar" on @moltbook 🦞

Verification: kelp-HBDZ

[Kalshi @Kalshi]

JUST IN: 50% chance Bitcoin drops below $80K

[Christianity Today @CTmagazine]

“The Chosen Adventures,” an animated spinoff of the well-known adult show about Jesus’ life, educates our smallest Bible scholars.
https://t.co/BfQmxMNtrm

[ZitoSalena @ZitoSalena]

"I realize I am standing here because people took time with the least."

Gratefulness fits well on everyone.

[The Vigilant Fox 🦊 @VigilantFox]

CNN’s Van Jones shocks viewers by putting the mainstream media on blast for IGNORING the mass slaughter of Christians in Nigeria.

“The fact that there’s almost no response from the global left and no attention from mainstream media is a CRIME against African people, black people, and human rights.”

MAHER: “You’re talking about young people. A lot of them seem to know one thing: white people did some very bad things in this world, and they certainly did. But there are other things to know… Nigeria: this is an actual planned genocide. They really want to kill all the Christians in that country, and they are systematically doing it.”

VAN JONES: “And the fact that there’s almost no response from the global left and no attention from mainstream media is a crime against African people, black people, and human rights. I agree with that 100%.”

Van Jones then laid out a theory about why networks like CNN have failed to cover the crisis in Nigeria. It’s one that will for sure get people talking.

[Tim Allen @ofctimallen]

When Erika Kirk spoke the words on the man who killed her husband: “That man… that young man… I forgive him.”  That moment deeply affected me.  I have struggled for over 60 years to forgive the man who killed my Dad. I will say those words now as I type: “ I forgive the man who killed my father.”
Peace be with you all.

[Jake Tapper 🦅 @jaketapper]

.⁦@jimmykimmel⁩ on Erika Kirk:

[Dr. Joshua Slysz @DrJoshuaSlysz]

Gut Check: Everything You Didn’t Know About the Microbiome. A daily 7-part 🧵 to understand you and your gut. #microbiome #guthealth

[Dr. Joshua Slysz @DrJoshuaSlysz]

🦠What if your gut bacteria could soak up toxic forever chemicals?

A new @NatureMicrobio study shows that common gut microbes like Bacteroides uniformis rapidly bioaccumulate PFAS—harmful pollutants in water & cookware—and help flush them out.

Probiotics as detox tools?
🔗 https://t.co/drpNJoMZHs
#Microbiome #PFAS #Health #GutHealth #Science

[garth slysz @slysz]

The Bacteria that blocks GLP-1

Recent research has identified specific gut bacteria that actively impair weight management, regardless of dietary discipline or medication use. Desulfovibrio species, sulfate-reducing bacteria found in dysbiotic gut microbiomes, represent a significant metabolic disruptor.

These pathogenic bacteria produce hydrogen sulfide, a cytotoxic compound that compromises the cellular machinery responsible for GLP-1 hormone production. This biochemical interference creates a cascade of metabolic dysfunction:

- Impaired satiety hormone synthesis
- Increased systemic inflammation affecting receptor sensitivity
- Compromised intestinal barrier integrity, leading to endotoxin translocation

This bacterial interference explains the significant inter-individual variation in weight loss outcomes, even among patients following identical protocols. When Desulfovibrio populations predominate, they actively counteract both endogenous metabolic signaling and pharmaceutical interventions.

The encouraging finding is that gut microbial populations are modifiable through targeted interventions. Metabolic resistance often reflects ecosystem dysfunction rather than permanent physiological impairment.

Understanding these microbial mechanisms offers new therapeutic targets for sustainable weight management.

Read the full analysis in Part 2:​​​​​​​​​​​​​​​​

https://t.co/WfypV17208

[garth slysz @slysz]

Beer Gut 2

‘Why Your Gut Microbiome influences Your Weight Loss Success, with or without Medication’

The hidden biological system that controls your metabolism.

Your body has an elegant signaling system that controls appetite, blood sugar, and fat burning. When food hits your intestine, special cells release a hormone called GLP-1. Think of it as a “key” that unlocks metabolic switches throughout your body.

This key opens the “I’m full” switch in your brain, the “release insulin” switch in your pancreas, and the “stop storing fat” switch in your liver. It’s like a master key that coordinates your entire metabolism.

But here’s what’s wild. Your gut bacteria influence this entire system. They sway how many keys your body makes AND whether those metabolic locks actually work when the keys try to turn them.

Good bacteria keep your key-making cells running smoothly and oil your metabolic locks so they turn easily. Bad bacteria literally poison the factories and create inflammation that jams the locks with rust.

Weight loss medications like Ozempic work by flooding your system with extra manufactured keys. But if your locks are jammed by harmful bacteria, even extra keys won’t work well. This explains the huge variation in results between people.

The amazing part? This system works the same whether you’re taking medication or relying on your body’s natural keys. Your microbiome is secretly controlling your metabolic success either way.

Part 2 breaks down exactly how this invisible ecosystem determines your weight loss results:​​​​​​​

https://t.co/WfypV16uaA

[garth slysz @slysz]

The Beer Gut. Turns out those beers aren't making you fat because of the calories - they're damaging your intestinal barrier like poking holes in a coffee filter with a pencil. When your gut barrier gets compromised, bacterial toxins leak into your bloodstream, triggering inflammation throughout your body. This inflammation causes your body to produce excess cortisol, which specifically promotes fat storage around your midsection.

The science is pretty mind-blowing. According to research from *Nature*, "Ethanol disrupts epithelial tight junctions and increases paracellular permeability by altering the expression and localization of junctional proteins such as occludin and ZO-1." Basically, alcohol dissolves the biological "glue" holding your gut cells together, creating gaps where inflammatory substances can leak through. At the same time, alcohol kills off the beneficial bacteria that would normally help repair this damage.

The worst part? This creates a vicious cycle - the belly fat you develop actually produces its own inflammatory signals, keeping your cortisol elevated and your body in fat-storage mode even after you stop drinking. The article explains why just cutting calories and exercising often isn't enough to lose a beer gut - you're not fighting calories, you're fighting a damaged biological system stuck in survival mode. Really makes you rethink that nightly beer or two. read the article: https://t.co/cNTupAr5Iq

[garth slysz @slysz]

'The Beer Gut'. Alcohol harms the gut barrier allowing inflammatory factors to constantly trigger cortisol. But there is help from your gut biome!
https://t.co/MlESL34fVC

[Dr. Joshua Slysz @DrJoshuaSlysz]

🔮 While this research doesn't prove causality, it highlights promising microbes like Coprococcus as potential targets for mental health interventions. Could psychobiotics (mood-boosting probiotics) be the future? 🤔 #gutmicrobiome #research #health

[garth slysz @slysz]

'The Beer Gut' is the latest substack post by Josh and me. It's not just the calories. Regular alcohol damages your gut barrier, flooding your system with inflammation and promoting fat storage. But good news, this metabolic handcuff can be fixed. @NaturePortfolio https://t.co/cNTupAr5Iq

[Lawrence M. Krauss @LKrauss1]

This is a very clear and readable article on antibiotics, fiber, probiotics, and gut microbiome.. Recent research challenges many previous assumptions. Read it. https://t.co/5t2HaI7Znv

[garth slysz @slysz]

Antibiotics disrupt your gut’s ecosystem. Recovery isn’t probiotics—it’s ecological succession. Feed pioneers with fiber, rebuild networks, restore diversity. My latest Substack dives into the science & a practical plan. 🌱💊 #Microbiome #Health
https://t.co/eovocNIleh