Congratulations to Ayoola @smith_ayoola for passing his dissertation proposal defense yesterday! It's been exciting to see his enzyme engineering project succeed!
Out now, we use bioinformatics+metabolomics to uncover a plant biosynthetic cassette responsible for diverse cyclic peptides. We apply this to find new NPs in Coffea. Finally, we reconstitute the first enzyme activity for a split BURP peptide cyclase!
https://t.co/jkeiInMgRM
As part of the 40th anniversary of @TrendsinBiotech, we spotlight an achievement in NP production. In 2013, Paddon et al reported 25g/L fermentation of artemisinic acid coupled with synthetic steps to yield the essential antimalarial drug artemisinin.
https://t.co/5vysOhstne
We have an opening for a NIH-funded postdoc in the lab! Our research focuses on the discovery and engineering of new RiPP natural product biosynthetic pathways using bioinformatic and in vitro approaches. See details below. #chempostdoc