Sofiya Hupalo

Neuroscientist interested in supporting mental health research & early career scientists. Views/tweets ≠ endorsement

[NPP-Digital Psychiatry and Neuroscience (DPN) @dpn_journal]

One week left to apply for our Editors’ New Investigator Award ⬇️⬇️⬇️

https://t.co/yqOa99SQVq

[Psychedelic Alpha @Psyched_Alpha]

BREAKING: President Trump Signs Executive Order to Accelerate Psychedelic Research and Access

This is a breaking story. More to follow.

[Alex Kwan 關進晞 @kwanalexc]

Excited to read this preprint by @YiZuoUCSC, using 2p imaging to track spines following psilocybin.

Many similarities with our findings. The new study crucially also tested dose dependence and dived deep into spine characteristics like clustering.

👉 https://t.co/s1uubN288P

[NPP-Digital Psychiatry and Neuroscience (DPN) @dpn_journal]

Learn more about the recent cohort of recipients of DPN's New Investigator Award, and apply by May 18th!

https://t.co/trhotGTGfD

[Sofiya Hupalo @sofiyahupalo]

@therealRYC The head twitch has been demonstrated to be a readout of 5HT2A receptor psychedelic potency, not a readout of “psychedelic experiences.”

I don’t think it’s possible to evolve on this issue bc we can’t ask mice about their subjective experiences. We test the hypothesis in humans

[Sofiya Hupalo @sofiyahupalo]

Very cool structural biology and molecular pharmacology study on psychedelic mechanisms of action.

But, I cringe at references to hallucinations in mice, even with qualifiers about limitations of animal models. We need to be more precise in our descriptions of animal behavior!

[Robert Y. Chen @therealRYC]

🚨 The NO TRIP mushroom for depression

We finally know how psychedelics cause hallucinations vs. therapeutic effects at the 5-HT2A receptor.

Gi signaling drives the trip, Gq drives the relief.

And they just designed a non-hallucinogenic analog to prove it 🧵

[NPP-Digital Psychiatry and Neuroscience (DPN) @dpn_journal]

This Award offers eligible early independent investigators a waived article processing charge ($2,190) to support open access publication of their original work in DPN.

See link for more details and stay tuned for the next call for papers!

https://t.co/Kouutczsc7

[NPP-Digital Psychiatry and Neuroscience (DPN) @dpn_journal]

🌟Announcing the next cohort of the DPN Editor’s New Investigator Waiver Award recipients🌟

Dr. Nicole Zürcher, MGH/@harvardmed
Dr. Jennifer Goldschmied, @Penn
Dr. Sarah Sperry, @DrSarahSperry @UMich

Congratulations! We're proud to support your work👏

[Jared Saletin @JSaletin]

The sleeping brain influences the waking mind.

This was a fun one. A brief one-stop shop to sleep theory, measurement, and interpretation, with a focus on the EEG and its relevance to psychiatric research.

Hope it's useful!

@BrownPsychiatry @BradleyHospital

[NPP-Digital Psychiatry and Neuroscience (DPN) @dpn_journal]

Our new Deep Dive covers a study by @Auerbach_Lab_CU @DPagliaccio @CarterFunkhous1 & colleagues, which linked EEG-based brain connectivity patterns with emotional expression from text messages to identify neural markers of depressive symptoms in teens

https://t.co/9M0ILnoCTE

[NPP-Digital Psychiatry and Neuroscience (DPN) @dpn_journal]

Recapping the #ACNP2026 study group, “Centering Lived Experience in Psychiatric Neuroscience Research”

We asked the panelists, what could NIH leadership do to be more supportive of trainees with non-traditional career paths, which is common among researchers with lived experience of mental illness?

[NPP-Digital Psychiatry and Neuroscience (DPN) @dpn_journal]

Our latest Deep Dive covers a study that developed a deep learning model to classify sleep stages from single channel EEG recordings in rats🐀. It predicted key parameters of sleep architecture, reducing the need for labor-intensive manual annotation.

https://t.co/wEQTqTnSOo

[Al Kaye @akaye]

We're interested in hiring a post-baccalaureate research associate to work in circuit and systems neuroscience studies of anxiety. Please reach out - my email is listed at https://t.co/oXlkPsGXk0 - if interested or share with undergraduate/recent grads who may be interested.

[Neuropsychopharmacology @npp_journal]

Recent US data shows overdose deaths involving both synthetic opioids & stimulants rose from 2018 until 2023, then declined sharply in 2024, driven by decreases in opioid-involved deaths. Despite recent declines, polydrug overdose mortality remains high

https://t.co/v4ynlIKP1N

[Britton Barbee, PhD @brittonrae5]

First ACNP is going to be tough to top! Thanks to everyone who stopped by to learn about @dpn_journal 🫶🏻🧠💻 #acnp2026

[NPP-Digital Psychiatry and Neuroscience (DPN) @dpn_journal]

Thank you all for an unforgettable #ACNP2026 full of cutting-edge science, insightful discussions, and positive energy!

See you next year in San Diego for #ACNP2027!

[Sofiya Hupalo @sofiyahupalo]

Last day of #ACNP2026!

Head over to Poseidon III-IV this morning from 9-11 to hear about how cross-species functional brain biomarkers are being used to improve translation and facilitate drug development in psychiatry 🧠

[NPP-Digital Psychiatry and Neuroscience (DPN) @dpn_journal]

🥁🥁The top 3 winners of #ACNP2026 Trivia are🥁🥁

1. Christine Ann Denny, @DrChristineAnnD
2. Catharine Mielnik
3. William Stoops, @WilliamStoops

Congratulations and thank you for participating! 🎉🧠

[NPP-Digital Psychiatry and Neuroscience (DPN) @dpn_journal]

Thinking about whether you should promote your next research paper on X, Bluesky, or *Reddit*?

Stop by @brittonrae5’s poster #1 tonight at #ACNP2026 to learn about how these 3 platforms differ in terms of engagement and online attention driven by posts about DPN articles.

[NPP-Digital Psychiatry and Neuroscience (DPN) @dpn_journal]

Hey #ACNP2026 👋

Are you interested in serving as a reviewer for @dpn_journal and @npp_journal?

Scan this QR code to fill out a form and tell us more about yourself!