SPACEtrial

ISRCTN17251494. Perioperative Translational Medicine and Therapeutics, William Harvey Research Institute, QMUL. CI: Gareth Ackland. [email protected]

[SPACEtrial @SPACEtrial]

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[AcklandLab @AcklandLab]

Long-Term Effects of the Abdominal Aortic Aneurysm Model in Rabbits Prepared by Pancreatic Elastase Combined With Angiotensin II. https://t.co/ftmaoflmVV

[AcklandLab @AcklandLab]

Vitamin D and cardiovascular disease in chronic kidney disease. https://t.co/8wy3IclvoD

[AcklandLab @AcklandLab]

Pre-treatment with angiotensin-(1-7) inhibits tumor growth via autophagy by downregulating PI3K/Akt/mTOR signaling in human nasopharyngeal carcinoma xenografts. https://t.co/ZDl87Mm6Nu

[SPACEtrial @SPACEtrial]

@milliken_don @AcklandLab ...exactly

[SPACEtrial @SPACEtrial]

@rupert_pearse I could go on...

[SPACEtrial @SPACEtrial]

@rupert_pearse Not to mention apparent implicit clinical faith in the current taxonomy of disease and incomplete mechanistic understanding......

[SPACEtrial @SPACEtrial]

@rupert_pearse Not to mention apparent implicit clinical faith in the current taxonomy of disease and incomplete mechanistic understanding......

[SPACEtrial @SPACEtrial]

Welcome to Twitter... @AcklandLab.... @_tomabbott @rupert_pearse @ShaunMmay @BJAJournals @HughHemmings @B_XTA

[SPACEtrial @SPACEtrial]

@CarvalB ....buy shares in remifentanil......

[SPACEtrial @SPACEtrial]

@ShaunMmay @uclh @robcmstephens @shamir_karmali ... we need mechanistic/translational perioperative clinical studies like this to improve outcomes.

[Shaun May @DrShaunMay]

200th patient recruited for #XMINS study on #WorldanaesthesiaDay. Great job #perioperative #research #nurses (Gladys and Anna) @uclh @robcmstephens @shamir_karmali

[Daniel J Drucker @DanielJDrucker]

Some New Insights Into GLP-1 Action on the Heart, Indirect Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1) | @CircAHA : Arrhythmia and Electrophysiology https://t.co/3dWOyYGOPr

[Hugh Hemmings @HughHemmings]

The BJA at the ASA, representing the leading global journal of anaesthesia @BJAJournals

[SPACEtrial @SPACEtrial]

@bangash_mansoor @traumagasdoc @david__highton ....would be quite remarkable (and a major selling point😜) for periop Medicine to be the ONLY clinical specialty to find ACEi/ARBs to be detrimental....... we need equipoise and @SPACEtrial

[SPACEtrial @SPACEtrial]

@bangash_mansoor @traumagasdoc @david__highton @SPACEtrial .....underlying substrate or drug? Given variable duration of action of ACEi/ARBs, the answer is simply not out there.

[SPACEtrial @SPACEtrial]

@bangash_mansoor @traumagasdoc @david__highton Worth emphasising that the paper you have pinged through concentrates on Ischaemia..... which accounts for <10% of periop troponin bumps, which occur in at least 35% higher risk patients . (And that’s over generous) @SPACEtrial @BJAJournals @rupert_pearse @_tomabbott

[SPACEtrial @SPACEtrial]

@traumagasdoc Inflammation is a player: https://t.co/g4hofWJ85M
@SPACEtrial

[SPACEtrial @SPACEtrial]

@BillFawcett @traumagasdoc .....hmmmm... even though we don’t really understand what it’s measuring !? https://t.co/jvGYWaZNnU