Spray Healthy

nasal vaccines (Someday) • Novavax • Pro-Mask • not medical advice (DYOR)

#CovidisAirborne #VaccinesPlus

[Spray Healthy @sprayhealthy]

@DonEford Fingers crossed!!

[Spray Healthy @sprayhealthy]

@mimizima_ And it turns out that's most of the population. Dishonest, delusional and willfully ignorant.

[Spray Healthy @sprayhealthy]

Why do people think it’s good to be chill/relaxed about viruses and illness in general? It’s not a badge of honour it’s a badge of ignorance.

[Spray Healthy @sprayhealthy]

@FrankHamburg3 @MaureenLangloss You wish! Maybe read some science for once in your life.

[Spray Healthy @sprayhealthy]

@PROUDKYAMERICAN @MaureenLangloss You are a massive dumbshit.

[Biff #SARSisAirborne 🍉 @Biff234523]

🚨💊HUGE news: @US_FDA has finally granted approval to @ShionogiUS’s Xocova (Ensitrelvir), a 2nd-generation antiviral targeting SARS-CoV-2.

The approval is for the indication of “post-exposure prophylaxis of COVID-19 following contact with an individual who has COVID-19”. However, just like with any drug, it can obviously also be used off-label (e.g. treatment of both acute COVID or Long COVID).

In Japan, Xocova received Emergency Use Authorization for the treatment of acute COVID all the way back in November 2022, received full approval in March 2024, and an expansion to include post-exposure prophylaxis in March 2026.

The post-exposure prophylaxis indications are based on the SCORPIO-PEP trial (https://t.co/Dxv0lhS2CM), where Xocova reduced the incidence of COVID-19 after household exposure by 67%, from 9.0% down to 2.9%.

Mechanically, Xocova is the same class of drug as Paxlovid - a 3C-like protease inhibitor that inhibits viral replication. From our best understanding, Xocova is probably slightly more potent than Paxlovid, but the more definitive advantage is that it comes with less side effects and less drug interactions (which are caused by the Ritonavir component of Paxlovid, added to boost the concentration of the actual antiviral, Nirmatrelvir).

Xocova should be useful for lowering viral load during an acute infection, especially if taken within a couple or days of symptom onset, which may help shorten the duration of acute symptoms. Will it do anything to prevent long-term damage or the development of Long COVID? Almost certainly not, just like Paxlovid, but I’d be more inclined to tell people that it’s worth trying if we’re no longer dealing with the side effect profile of Paxlovid.

Where it makes the most sense to use Xocova, just like with Paxlovid, is as a component of polytherapy for Long COVID driven by viral persistence. The big issue there, however, is that you need a longer course of these antivirals than most physicians are willing to prescribe and/or most insurance companies are willing to cover. And they’re generally not very effective as a monotherapy, you need to pair these oral antivirals with other therapies for better coverage and tissue penetration (eg. monoclonal antibodies and Nuvaxovid, and potentially even a 2nd antiviral like Remdesivir).

All in all, this is a very important and long overdue approval. It’s not a game-changing silver bullet, and notably, nobody should really be expecting to use or rely on Xocova in a way that they wouldn’t be open to using or relying on Paxlovid in the present. But there are plenty of applications for it, and Xocova should absolutely be seen as another Swiss cheese layer / tool in the toolbox for COVID conscious community members and any allied medical providers.

[✮ راينر براون @dondawastaken]

Never forget that you are the main data center. Drink water, and consume as much literature as possible.

[Spray Healthy @sprayhealthy]

@Trev_Ford_North Somebody needs to review the definition of entitlement. It's not "entitled" to protest against a data centre sucking up our water. Maybe the word you were looking for was enlightenment!

[Spray Healthy @sprayhealthy]

@GrahamPudek @bobmackin It’s actually going to be a Graham Pudek Only Lockdown where only you aren’t allowed to leave your house because you are a danger to society.

[Avi Lewis @avilewis]

It’s time to build affordable homes, a national network of public grocery stores, electric buses and an east-west clean energy grid. Not massive corporate AI data centres unleashed without any democratic debate.

There's also no real data sovereignty in an AI ecosystem dominated by U.S. tech giants. Telus may be Canadian-owned, but it has already transferred 14 petabytes of Canadian data onto Google Cloud as part of its AI strategy.

This is a technology that will bring sweeping changes at a scale and speed never seen before. Canadians deserve real oversight and a robust regulatory framework before we rush ahead.

That’s why we’re calling for an immediate pause on the construction of any new AI data centres until strong federal guardrails are in place.

We can’t sit back and let Big Tech billionaires decide our future for us.

https://t.co/FFYBrZnc4G

[Spray Healthy @sprayhealthy]

@MarkJCarney It's time for you to be replaced by Avi Lewis, a leader who actually cares about the future of Canadians.

[Don Ford - The People's Strategist - @DonEford]

Some folks are asking if this hantavirus outbreak can become a pandemic...

So, let's look at where we are...

From a single infection in late March, this has turned into 173 exposed people in a month and a half since the first exposure.

Every single person has the ability to expose this many people, and even if only a small portion of people test positive, if they are not quarantined and continue to expose others when asymptomatic, then we expect the growth to continue.

So, without even doing the math, on a six-week cycle of 173 exposed, then this could get out of hand very quickly.

And denying that it could is the best way to make that happen.

[Spray Healthy @sprayhealthy]

@SmellicusCuntis @stanley_tyrel @dsonoiki Jim, you are a diarrhea-brained dingbat!

[Brunette @mimizima_]

It’s so fucking crazy that everyone literally has l0ng c0v1d and we’re just supposed to pretend that chronic fatigue and memory loss and cancer and strokes and heart attacks are just part of being in your 30s like girl

[Friesein @Friesein]

🇨🇦 Novavax Availability Update

Novavax will reportedly be available in British Columbia, Canada this coming fall.

Thank you to everyone who advocated for this!

Has anyone received word in any other provinces yet?

[Biff #SARSisAirborne 🍉 @Biff234523]

📢💉🇨🇦Big update on Novavax / Nuvaxovid availability for Canada!

Today, @SanofiCanada has announced, via @CNWNews, that they have completed the acquisition of Nuvaxovid market authorization from @Novavax and that Nuvaxovid will be available to Canadians in the fall.

• Nuvaxovid will be made available in Canada by Sanofi for the fall 2026-2027 season

• Provincial and territorial availability will be confirmed pending ongoing discussions and provincial assessments

"With the launch of Nuvaxovid, a non-mRNA protein-based COVID-19 vaccine, Sanofi is now able to offer Canadians greater choice when it comes to COVID-19 protection. The availability of Nuvaxovid means that every Canadian will have the opportunity to access their personal COVID-19 vaccine choice. Canadians have clearly expressed a need for a non-mRNA option when it comes to COVID-19 protection. With this transfer, Sanofi can now respond to that need." - Delphine Lansac, General Manager, Canada, Vaccines at Sanofi.

Press release: https://t.co/0gCZoUh0Ol

Sanofi appears to have created a webpage for the Canadian product here, which includes the current product monograph: https://t.co/xaMhyxfHnB

[Harsha Walia (she/her) @HarshaWalia]

The BC Teachers Federation, the province wide labour union representing over 40,000 teachers, has just passed a resolution in support of BDS!

The first province-wide motion to support BDS in solidarity with Palestine!!

[Spray Healthy @sprayhealthy]

@koicows @vee9zee @CTVNewsVI You’re uneducated about harm reduction. Best not to speak up until you read some data and research.

https://t.co/LJDg9WW2Se

[CooperBaggs 💰🍞 @edgaralandough]

We are overstimulated and we don't even notice. Netflix while eating. Reels in the bathroom. Music while cooking. Podcasts on walks. We consume by default, not by intention. You keep filling every gap, then wonder why you feel foggy and unmotivated. Boredom and silence are the real growth drivers. They give you space to think and create. That's when solutions show up for problems that have been stuck for months. Leave some room.

[COPE: Coalition of Progressive Electors @COPEVancouver]

This disgraceful, harmful, and unethical behaviour should not be tolerated from any elected official, let alone the Mayor of Canada’s third-largest city.

Statement: https://t.co/TuCDteyeeE