Created a helpful infographic for those who are struggling to understand why Jill and/or Chris would very likely NOT get hung up on Zeno's face and would probably NOT project their Wesker baggage onto him.
Zeno isn't Wesker, and those who knew Wesker would see it immediately.
The fact of the matter is that Zeno fits into Leon's story better than he would in Chris or Jill's because of HIS ACTUAL CHARACTER -- meaning his affiliations, his temperament, and his motivations.
Zeno is more than just a Wesker clone. He's the anthropomorphized form of the corruption within the government that Leon serves. He exists to show that Leon and Sherry don't serve blindly at the whims of the government, and they WILL rebel if they receive orders that are illegal or unjust.
I obviously can't prove this, but I believe that the only reason why Zeno looks like Wesker (and has his moveset) is as a consolation prize/apology for Capcom killing Wesker before Leon got to take a crack at him. While it's true that this opens up doors and possibilities for expanded lore opportunities down the line, RE's history as a series has me pessimistic in expecting any follow-through with it.
But the reaction to Zeno has been a damning indictment of RE's fanbase. Post-RE9 RE fandom has been miserably depressing for those of us who actually care about storytelling and not just "lore."