Staley Lab

pre-mRNA splicing lab at The University of Chicago

[Staley Lab @staleylab]

Interested in human co-transcriptional #splicing? Together w/ @yang_i_li lab, we've developed CoLa-seq and found lariat formation timing varies widely, can be fast, and depends on several genomic features. https://t.co/ctiIyT3P0Z #RNA (1/8)

[Staley Lab @staleylab]

If you cannot access the amazing work from Yi and our collaborators in the @yang_i_li lab and Ruthenberg lab. Access here for free access over the next 2 months. https://t.co/B5RchazPtJ

[Staley Lab @staleylab]

This work from lead by Yi Zeng has found a great home @MolecularCell. If you're interested in branch-points, timing of splicing, and order of splicing take a look. https://t.co/fKc8VGbq2i

[Staley Lab @staleylab]

Our data imply a role for ubiquitylation of the export adapter Yra1p in undocking mRNAs from the nuclear basket, so mRNA can enter the nuclear pore. 3/3

[Staley Lab @staleylab]

We are excited to share our recent work on the discard of mRNA splicing intermediates that are trafficked by export factors and require the nuclear basket. 1/3
https://t.co/dqsdpoAQGw

[Staley Lab @staleylab]

Our data challenge a general role for Mlp1 of the nuclear basket in the quality control of mRNA export and instead support a role for Mlp1 in mRNA export in yeast. 2/3

[Staley Lab @staleylab]

@frequencies The lab misses you too. It's exciting to see you moving on to new things, though.

[Horne-Badovinac Lab @SHBLab]

Check out our latest! This work has been part of an incredibly fruitful lab shift toward live imaging of cell dynamics.

[craddoctor.uag @frequencies]

A former post-doc from the @staleylab just launched a board game company focusing on teaching STEM/STEAM concepts. The first game is about pre-mRNA splicing!

https://t.co/NbZkYKhNxU

[Staley Lab @staleylab]

@JohnathonMHall Congratulations!

[Staley Lab @staleylab]

Excited to see this work online! @JohnathonMHall et al have developed a novel tool, Omegazyme, to knock down lncRNAs and uncovered a new lncRNA in chemokine regulation.

[Staley Lab @staleylab]

The one and only @NonCodyRNA is defending his dissertation.

[bioRxiv @biorxivpreprint]

Profiling of Nascent Lariat Intermediates Reveals Key Genetic Determinants of the Timing of Human Co-transcriptional Splicing https://t.co/ac7WQndcez #bioRxiv

[Staley Lab @staleylab]

Lastly, we'd like to thank all of our co-authors: @aiskrish and @yichen_hou from Staley lab, Ben from @yang_i_li lab, Huilin, as well as John and Alex from Ruthenburg lab. Please check out our preprint here: https://t.co/ctiIyT3P0Z. -Yi (8/8)

[Staley Lab @staleylab]

Interested in human co-transcriptional #splicing? Together w/ @yang_i_li lab, we've developed CoLa-seq and found lariat formation timing varies widely, can be fast, and depends on several genomic features. https://t.co/ctiIyT3P0Z #RNA (1/8)

[Staley Lab @staleylab]

Together, these findings establish a critical framework for future studies of the mechanisms and regulation of splicing. (7/8)