steady☯️

Janitor of DeSci space | Dev Roident: the chad mouse $psmice | Building @desciatoms @scignal_alpha

[steady☯️ @steadymousy]

Tirzepatide + existing drug potentially have compliment each other

[Purrptide @purrptide]

🏷️ Diabetes Treatment · 🔑 Tirzepatide

📌 1266-OR: Tirzepatide and Pioglitazone Combination Therapy Synergistically Improves Insulin Sensitivity and Adipose Tissue Remodeling
👥 MOHAMED ABU-FARHA, DANIEL VATNER, MOHAMMAD QADDOUMI
📅 2026-06-07 · Diabetes

🔍 Summary:
Combining Tirzepatide and pioglitazone resulted in significant improvements in insulin sensitivity and adipose tissue remodeling in male Sprague Dawley rats, with Tirzepatide mitigating pioglitazone-induced weight gain. The combination also showed additive reductions in glucose area under the curve compared to Tirzepatide alone.

💡 Consult with your doctor or a healthcare professional to discuss potential new treatment options for type 2 diabetes, including combination therapies like Tirzepatide and pioglitazone, although more research is needed before they become available.

🤖 AI Analysis:
New research suggests that combining two diabetes medications, Tirzepatide and pioglitazone, may lead to improved insulin sensitivity and weight management. This breakthrough could pave the way for more effective treatments for type 2 diabetes and obesity. Further studies are needed to confirm these findings.

📊 Evidence: Preliminary (Small/Observational)
📊 Quality Score: ██████░░░░ 6/10
├ Evidence strength: ████░░░░░░ Preliminary
├ Actionability: ███░░░░░░░ Low
└ Scientific impact: ███████░░░ Moderate

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[steady☯️ @steadymousy]

@jefftangx want

[steady☯️ @steadymousy]

Interesting data based on reports from 13k users of Retatrutide on Reddit. Side effects are actually bullish, means it actually has impact

#retatrutide

[Purrptide @purrptide]

🏷️ Peptides · 🔑 retatrutide

📌 Self-Reported Side Effects Among Reddit Users Taking Unapproved Retatrutide
👥 Neil K R Sehgal, Jena Shaw Tronieri, Benjamin Rader
🏛️ @Harvard
📅 2026-06-03 · medRxiv

🔍 Summary:
A study of self-reported side effects among Reddit users taking the unapproved peptide retatrutide found that the most common symptoms were appetite increase, fatigue, increased energy, nausea, food craving, insomnia, and elevated heart rate. These findings differ from those reported in phase 2 clinical trials, which were dominated by gastrointestinal events.

💡 Be cautious when considering the use of unapproved substances like retatrutide and carefully weigh the potential benefits against the possible side effects, especially if you're relying on online communities for information.

🤖 AI Analysis:
Unapproved peptide retatrutide is being used by thousands online, but what are the real side effects? New research reveals a different story than clinical trials, with users reporting appetite increases, fatigue, and more.

📊 Evidence: Preliminary (Small/Observational)
📊 Quality Score: ███████░░░ 7/10
├ Evidence strength: ███░░░░░░░ Preliminary
├ Actionability: ██████░░░░ Moderate
└ Scientific impact: ██████░░░░ Moderate
🔗 https://t.co/8FGrqEzfZC

[steady☯️ @steadymousy]

@MattMematic yeah I believe at least one peptide has mind-blowing potential (maybe Reta), so I check the latest research every day

[steady☯️ @steadymousy]

Interesting. GLP-1 not only has impact on weight loss, but on joint inflammation (or potentially on any kind of inflammations)

[Purrptide @purrptide]

🏷️ Pharmacology · 🔑 peptide, Tirzepatide

📌 Glucagon-like peptide 1 receptor agonist use and risk of arthroplasty for knee osteoarthritis: retrospective database analysis
👥 Victoria Carter, Ethan Desverreaux, Idris Amin
🏛️ @MayoClinic
📅 2026-06-02 · Regional Anesthesia & Pain Medicine

🔍 Summary:
The use of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) is associated with a significantly lower risk of total knee arthroplasty (TKA) in patients with knee osteoarthritis. The risk reduction is greater with longer treatment duration and newer generation agents.

💡 Consider talking to your doctor about the potential benefits and risks of using GLP-1 RAs for knee osteoarthritis, especially if you are at high risk of needing knee replacement surgery.

🤖 AI Analysis:
New research suggests that a type of medication called GLP-1 RAs may help reduce the risk of needing knee replacement surgery in patients with knee osteoarthritis. This could be a game-changer for people living with this debilitating condition. The study found that the risk reduction was greater with longer treatment duration and newer generation agents.

📊 Evidence: Moderate (Clinical study)
📊 Quality Score: ████████░░ 8/10
├ Evidence strength: ██████░░░░ Cohort Study
├ Actionability: ███████░░░ Actionable
└ Scientific impact: ███████░░░ Moderate
🔗 Read study

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[steady☯️ @steadymousy]

@256hax レアそうですね!

[steady☯️ @steadymousy]

Peptide -> Parkinson's treatment

[scignal @scignal_xyz]

🏷️ Neuroscience · 🔑 peptide

📅 2026-05-23 · PubMed
📌 Engineered neuronal exosomes mediate a-synuclein clearance to ameliorate Parkinson's disease.
👥 Lufei Chen, Xiaoling Lin, Mingzhi Fu

[Purrptide @purrptide]

@EliLillyandCo new Retatrutide data is insane it’s basically handing out bariatric surgery results in a syringe, letting patients delete up to a third of their body weight like an unwanted software update.

By hiring a "Triple G" hormone purrfect dream team to simultaneously mute hunger and torch fat, it safely completely breaks the metabolic matrix without giving your heart or liver any side-effect drama.

[steady☯️ @steadymousy]

wow peptide RS-FS can potentially increase effectiveness of cancer therapies by up to 61x 🤯

[Purrptide @purrptide]

🏷️ Oncology · 🔑 peptide

📌 Self-Assembly of Stimuli-Responsive Peptide Enhances Therapeutics by Specifically Disrupting Hepatocellular Carcinoma Lysosomes In Vivo.
👥 Renwei Jing, Xiaorong Kong, Jin Zhang
📅 2026-05-21 · PubMed

🔍 Summary:
A self-assembling peptide called RS-FS can disrupt lysosomes in cancer cells, enhancing the effectiveness of various therapies, including doxorubicin and Lenvatinib, in treating hepatocellular carcinoma. This peptide can increase the potency of these treatments by up to 61-fold in mice with this type of cancer.

💡 Consult with a healthcare professional about potential new treatments for hepatocellular carcinoma, as this research may lead to more effective therapies in the future.

🤖 AI Analysis:
A breakthrough in cancer treatment has been discovered, where a special peptide can increase the effectiveness of therapies by up to 61-fold. This innovative approach targets the root of the cancer cells, offering new hope for patients. Researchers are optimistic about the potential of this peptide to revolutionize the treatment of hepatocellular carcinoma.

📊 Evidence: Preliminary (Small/Observational)
📊 Quality Score: ████████░░ 8/10
├ Evidence strength: ████░░░░░░ Preliminary
├ Actionability: ██░░░░░░░░ Research Only
└ Scientific impact: ████████░░ High
🔗 Read study

Sent by Scignal · https://t.co/DJTVLBg84I

[steady☯️ @steadymousy]

CGRP Peptide@Rh-GelMA hydrogel just dropped:

CGRP peptide loaded gel that kills bacteria, calms inflammation, and supercharges new blood vessel growth

[Purrptide @purrptide]

🏷️ Wound Healing · 🔑 peptide

📌 All-in-one: a CGRP-encapsulated Rh-GelMA supramolecular dual-network hydrogel orchestrating immune-vascular coupling for diabetic wound healing.
👥 Xianglong Zhou, Jianhui Xiang, Hanhong Fang
📅 2026-05-16 · PubMed

🔍 Summary:
A newly developed supramolecular hydrogel, CGRP@Rh-GelMA, has been shown to accelerate wound repair in a diabetic rat model by promoting immune and vascular repair responses. The hydrogel exhibited antibacterial activity, reduced inflammation, and enhanced endothelial cell migration and vascular network formation.

💡 Explore emerging biomaterials and hydrogels as potential solutions for wound care and tissue engineering, and discuss these developments with medical professionals.

🤖 AI Analysis:
Imagine a gel that could heal diabetic wounds faster and more effectively. Scientists have developed a new hydrogel that shows promise in promoting immune and vascular repair, and it could change the way we treat wounds. This breakthrough could lead to better outcomes for patients with diabetic wounds.

📊 Evidence: Preliminary (Small/Observational)
📊 Quality Score: ██████░░░░ 6/10
├ Evidence strength: ████░░░░░░ Preliminary
├ Actionability: ███░░░░░░░ Moderate
└ Scientific impact: ███████░░░ Moderate

Sent by Scignal https://t.co/DJTVLBg84I

[DeSci Atoms @desciatoms]

$TRAC is up +80% detected on our bot detected 700 $TRAC buys https://t.co/KAbr5WtMfh

[steady☯️ @steadymousy]

Automate your peptide learning by receiving new studies on Telegram everyday with Scignal @scignal_alpha (free)

[steady☯️ @steadymousy]

Biopesticides with peptides 🔼-> Reduce the bad pesticides 🔽

[Purrptide @purrptide]

🏷️ Peptides · 🔑 peptide

📅 2026-05-16 · PubMed
📌 Cyclic lipopeptides anikasin, anikasinβ and anikasinγ produced from Pseudomonas sp. JQ36 and their biocontrol activities against Phytophthora capsici.
👥 Zongwang Ma, Xingyuan Zhou, Lu Zhang

🔍 Summary:
Researchers discovered three cyclic lipopeptides, anikasin, anikasinβ, and anikasinγ, that have the potential to control Phytophthora foliar blight on pepper plants by inhibiting germination and lysis of zoospores. These peptides could serve as novel biopesticides for sustainable pepper production.

💡 Consider supporting agricultural practices that utilize biopesticides like anikasin to reduce the environmental impact of pesticide use.

🤖 AI Analysis:
A breakthrough in sustainable agriculture could help reduce the environmental impact of pesticide use. Researchers have discovered three peptides that show promise in controlling a destructive disease that affects pepper crops. This innovative approach could lead to more eco-friendly farming practices.

📊 Evidence: Preliminary (Small/Observational)
📊 Quality Score: ██████░░░░ 6/10
├ Evidence strength: ████░░░░░░ Preliminary
├ Actionability: █████░░░░░ Moderate
└ Scientific impact: ███████░░░ Moderate

🔬 Related DeSci Projects:
→ Molecule ($MOLE) — The protocol powering DeSci — IP-NFTs for biomedical research
🔗 Read study

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[steady☯️ @steadymousy]

New findings: GLP-1 injectable therapies(Tirzepatide) may also have 🫀cardiovascular and 🫁renal benefits.

[Purrptide @purrptide]

🏷️ Obesity Treatment · 🔑 peptide, retatrutide, Tirzepatide
📊 Quality Score: ████████░░ 8/10

📌 EFFICACY AND SAFETY OF INJECTABLE INCRETIN THERAPIES IN THE MANAGEMENT OF OBESITY: A SYSTEMATIC REVIEW
👥 Fernanda Rodrigues Lopes, Travis Ricardo Johnson, Fabrício Soares Ferreira
📅 2026-05-14 · Seven Editora eBooks

🔍 Summary:
Injectable therapies like GLP-1 receptor agonists and dual GLP-1/GIP agonists have been shown to be effective in weight reduction, with mean losses ranging from 8% to 21%, and may also have cardiovascular and renal benefits. The triple agonist retatrutide showed promising results with weight reductions of up to 28%.

💡 Consult with a healthcare professional to discuss the potential benefits and risks of injectable therapies for weight loss and determine if they may be a suitable treatment option.

🤖 AI Analysis:
New hope for obesity treatment: injectable therapies have been shown to be effective in weight reduction and may also have cardiovascular and renal benefits. These treatments could be a game-changer for those struggling with obesity. Medication can be a powerful tool when used under medical supervision.

📊 Evidence: Strong (RCT/Meta-analysis)
📊 Quality Score: ████████░░ 8/10
├ Evidence strength: █████████░ Meta-analysis
├ Actionability: ██████░░░░ Moderate
└ Scientific impact: ████████░░ High

🔬 Related DeSci Projects:
→ PsyDAO ($PSY) — Funding psychedelic medicine research via decentralized governance
🔗 Read study

Sent by Scignal · https://t.co/DJTVLBg84I

[steady☯️ @steadymousy]

GV1001 PEPTIDE for Alzheimer's treatment👀

[Purrptide @purrptide]

🏷️ Neuroscience · 🔑 peptide

📌 GV1001: repurposing a telomerase-derived peptide for neurological therapeutics.
👥 Kyoungho Suk, Won-Ha Lee
📅 2026-05-14 · PubMed

🔍 Summary:
A peptide called GV1001, originally developed as a cancer vaccine, has shown promise in treating neurodegenerative diseases such as Alzheimer's disease, stroke, and depression by promoting neuroprotection and remyelination. In Phase 2 trials, GV1001 demonstrated statistically significant cognitive improvements in Alzheimer's disease patients with a good safety profile.

💡 Ask your doctor about the latest developments in GV1001 research and its potential as a treatment option for neurodegenerative diseases.

🤖 AI Analysis:
New hope for neurodegenerative diseases: a peptide originally developed as a cancer vaccine shows promise in treating Alzheimer's, stroke, and depression. GV1001 promotes neuroprotection and remyelination, offering a potential new treatment approach. Further research is underway to confirm its effectiveness.

📊 Evidence: Moderate (Clinical study)
📊 Quality Score: ████████░░ 8/10
├ Evidence strength: ██████░░░░ Clinical Trial
├ Actionability: ████░░░░░░ Moderate
└ Scientific impact: ███████░░░ Moderate

🔬 Related DeSci Projects:
→ ResearchHub ($RSC) — GitHub for science — open peer review with token rewards
→ Opscientia ($OPSY) — Open science infrastructure for decentralized research
🔗 Read study

Sent by Scignal · https://t.co/DJTVLBg84I

[steady☯️ @steadymousy]

Scignal just found peptide breaking news in obesity treatment: a new oral medication called orforglipron has been shown to help people maintain weight loss over time. This could be a game-changer for those struggling to keep the weight off.

📊 Evidence: Strong (RCT/Meta-analysis)
📊 Quality Score: ████████░░ 8/10
├ Evidence strength: █████████░ Strong RCT
├ Actionability: ██████░░░░ Actionable
└ Scientific impact: ███████░░░ Moderate

[Purrptide @purrptide]

🏷️ Obesity Treatment · 🔑 peptide, Tirzepatide

📌 Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
👥 Louis J. Aronne, Deborah B. Horn, Carel W. le Roux
📅 2026-05-12 · Nature Medicine

🔍 Summary:
Orforglipron, a once-daily oral medication, helped people maintain weight loss over 52 weeks, with 74.7-79.3% of weight reduction maintained compared to 49.2-37.6% with a placebo. This was observed in two cohorts of participants who had previously achieved weight loss with other medications.

💡 Consider talking to your doctor about orforglipron if you have lost weight and are looking for a medication to help maintain your weight loss.

🤖 AI Analysis:
Breaking news in obesity treatment: a new oral medication called orforglipron has been shown to help people maintain weight loss over time. This could be a game-changer for those struggling to keep the weight off.

📊 Evidence: Strong (RCT/Meta-analysis)
📊 Quality Score: ████████░░ 8/10
├ Evidence strength: █████████░ Strong RCT
├ Actionability: ██████░░░░ Actionable
└ Scientific impact: ███████░░░ Moderate

🔬 Related DeSci Projects:
→ Molecule ($MOLE) — The protocol powering DeSci — IP-NFTs for biomedical research
🔗 Read study

Sent by Scignal · https://t.co/DJTVLBg84I

[steady☯️ @steadymousy]

Fresh study on Urolithin A $URO @pumpdotscience

[Purrptide @purrptide]

🏷️ Mitochondrial Health · 🔑 Urolithin

📌 Effects of Urolithin A on Mitochondrial Homeostasis Disruption by LPS in C2C12 Myotubes
👥 Germán Tapia‐Curimil, Mayalen Valero‐Breton, Hermann Zbinden-Foncea
📅 2026-05-11 · Cellular Physiology and Biochemistry

🔍 Summary:
Urolithin A, a natural compound, was found to mitigate the negative effects of inflammation on mitochondrial function in muscle cells, by modulating TLR4 signaling and mitochondrial dynamics. This could have implications for disorders associated with mitochondrial dysfunction and inflammation.

💡 Consider incorporating foods rich in urolithin A, such as pomegranates and berries, into your diet, although more research is needed to confirm its effects in humans.

🤖 AI Analysis:
A natural compound called urolithin A has been shown to protect muscle cells from inflammation, potentially leading to new treatments for diseases like Alzheimer's and muscular dystrophy. This breakthrough could have significant implications for our understanding of mitochondrial health.

📊 Evidence: Preliminary (Small/Observational)
📊 Quality Score: ██████░░░░ 6/10
├ Evidence strength: ████░░░░░░ Preliminary
├ Actionability: ████░░░░░░ Moderate
└ Scientific impact: ███████░░░ Moderate
🔗 Read study

Sent by Scignal · https://t.co/DJTVLBg84I

[steady☯️ @steadymousy]

Scientists publish 10,000 papers today. You'll read 0.
Scignal fixes that.
@scignal_alpha

[steady☯️ @steadymousy]

Scientists publish 10,000 papers today. You'll read 0.
Scignal fixes that.
https://t.co/qURSM7gG67

[steady☯️ @steadymousy]

Delivering the freshest peptide studies straight from the labs (arXiv, bioRxiv, medRxiv, PubMed & OpenAlex). And it’s free. @scignal_alpha

[Purrptide @purrptide]

💊 PEPTIDES · 🔑 Tirzepatide

📌 Effect of Tirzepatide on Health‐Related Quality of Life in Japanese Patients With Obesity Disease: Patient‐Reported Outcomes From the SURMOUNT ‐J Study
👥 Hiroaki Masuzaki, Hirotaka Nagashima, Tomotaka Shingaki
📅 2026-05-10 · Diabetes Obesity and Metabolism

🔍 Summary:
Tirzepatide, a medication, significantly improved health-related quality of life in Japanese adults with obesity disease, showing benefits in both physical and psychosocial areas. The improvements were seen after 72 weeks of treatment.

💡 Consult with a healthcare professional to discuss potential treatment options, including tirzepatide, for managing obesity and improving quality of life.

🤖 AI Analysis:
New research reveals that the medication tirzepatide can significantly improve quality of life for individuals with obesity disease, enhancing both physical and mental well-being. This breakthrough could offer new hope for those struggling with obesity. The study's findings are based on a 72-week clinical trial involving Japanese adults with obesity disease.

📊 Evidence: Moderate (Clinical study)
📊 Quality Score: ███████░░░ 7/10
├ Evidence strength: ██████░░░░ Clinical Trial
├ Actionability: █████░░░░░ Moderate
└ Scientific impact: ██████░░░░ Moderate
🔗 Read study (https://t.co/gun3hqXGm1)

Sent by Scignal · https://t.co/DJTVLBg84I