STEM

Here for the science.

[Laura Coates @thelauracoates]

#Nevada @RepHorsford joins #TheLauraCoatesShow to discuss the "America's Workforce Act" and the companion bill "The National Apprenticeship Act" and the disparate economic impact of the pandemic on women on @SXMPOTUS @SIRIUSXM! Join the conversation!

[Céline Gounder, MD, ScM, FIDSA 🇺🇦 @celinegounder]

“My CV makes it look easy, but it hasn’t always been. For every paper or grant I have submitted, 80-90 % of them have been rejected, which is why I tell my students they have to love the pursuit of the question.” -⁦@CDCDirector⁩ ⁦@RWalensky⁩ https://t.co/i0g7Hk9USG

[NCATS @ncats_nih_gov]

#DYK what makes a translational scientist?

Translational scientists break down barriers & facilitate connections with researchers to speed up the process of scientific discovery. Learn about the other characteristics they share in our video: https://t.co/IPw7Aj0byn

[Ken Westover, M.D., Ph.D. @kenwestover]

Watch RAS wiggle! Here is our latest structure showing dynamics of a KRAS mutant found in RASopathies - KRAS P34R (mutation in red). Interesting connection with heterotrimeric G proteins. https://t.co/oUnskfhKvb.

[Jean Case @jeancase]

ICYMI - informed and thoughtful perspectives on Preparing for the Next Pandemic from an extraordinary leader, Dr. @SueDHellmann, who has led important institutions across sectors including @gatesfoundation and @UCSF. @WSJ

[Danielle Belardo, MD @DBelardoMD]

Doctors, nurses & ALL healthcare providers need adequate Personal Protective Equipment so they can treat patients without spreading COVID & also safely protect themselves.

Everyone can help us! Here is how:

CC: @DarilynMoyer @ACPinternists

Please share w/ everyone you can🙏

[Jen Heemstra @jenheemstra]

This past week has challenged each of us in unique ways, but we can all share the common experience of confronting unexpected challenges.

We also share the truth that we can’t do this alone. Don’t be afraid to ask for help, and don’t be afraid to offer help to others.

[Ashley Love Sumrall, MD, FACP, FASCO @AshleySumrallMD]

Dear elected officials for NC, we need some help. Please help us find #3Dprinters in the Charlotte area. We need #faceshields #masks #PPE for our healthcare teams caring for pts. #COVID19 We need printers, supplies, & some humans to help. Thx 🇺🇸

[The Economist @TheEconomist]

There is no treatment for 90% of rare diseases. Personalised medicines can target such illnesses https://t.co/lIVThy1odM

[The University of North Carolina at Chapel Hill @UNC]

Following guidance from the @StateDept and @CDCgov and #UNC’s prohibition of travel outside of North Carolina, all summer 2020 study abroad and international education programs are canceled. This includes undergraduate, graduate and professional programs https://t.co/W2BojKOQ63

[Mayo Clinic @MayoClinic]

"Individualized medicine, for us, is really understanding as much about each individual patient as we possibly can,” says @akeithstewart. https://t.co/2ofNJY1ZUh via @NewsHour @PBS @milesobrien

[Nikhil Wagle, MD (he/him) @Nikhilwagle]

Many thanks to our many collaborators and colleagues, and to our funders for supporting this work

[Wyatt Shields @WyattShieldsIV]

To all my macrophage friends: check out this awesome work by @ashishkulkarny and co-workers. Dual‐inhibitor‐loaded nanoparticles target M2 macrophages and simultaneously inhibit CSF1R and SHP2 pathways to repolarize TAMs.

[Nikhil Wagle, MD (he/him) @Nikhilwagle]

Clinically, this suggests that this resistance can be potentially overcome by targeting the specific RTK resistance mechanism — or perhaps by targeting nodes of convergence like MEK or ERK or SHP2, which would allow treatment of more disparate resistance mechs w fewer drugs

[Weill Cornell Leukemia @WCMLeukemia]

.@DrMonicaGuzman & colleagues analyzed PTPN11-mutated #AML samples for sensitivity to epichaperome inhibition, a new cancer-targeting strategy. Findings were presented at #ASH19 by @WeillCornell @nyphospital Hem/Onc Fellow Dr. Justin Kaner (@WxMD529). https://t.co/PzP8JLTMkw

[Environmental Science & Technology Journals @EnvSciTech]

Insights into sorption and desorption mechanisms of PFOA’s cationic and zwitterionic precursor compounds
https://t.co/yGx5paUcNq

[The Busta Lab @PlantsRChemists]

Happy #PhytochemicalFriday! Today: allicin, a (zwitterionic!) compound from garlic. Normal garlic cells contain alliin (an amino acid-like compound), but crushing garlic exposes alliin to an enzyme that converts it into allicin - the major contributor to the aroma of fresh garlic

[Nature Biotechnology @NatureBiotech]

A paper recently published in @nature from @liugroup discloses a ‘prime’ gene-editing system many years in the making. It has already been snapped up as the key founding intellectual property for Cambridge, Massachusetts-based startup Prime Medicine