Stephen Estes

building the future of food | also own an agency that weaponizes comms & accelerates growth for disruptive technology co’s | fundamentally, a man on a quest

[Stephen Estes @stephenestes1]

Every day you don’t pursue your dreams is one less day in the future you’ll have to experience them

[Matt Van Swol @mattvanswol]

🚨#BREAKING: A 28-year-old confirms he has spent the last 10 YEARS of his life interviewing World War II combat veterans to keep their stories alive...

...in fact, for the last 10 years, he has interviewed World War 2 veterans EVERY SINGLE DAY

He started as a teenager, ditching school to ride his BIKE to the local retirement home, walking up to the front desk and asking to, "meet some World War II heroes."

His name is Rishi Sharma.

He's crossed all 50 states and half the world.

He's slept in his car and lived on gas-station food to afford it.

He asks these men for hours of their memories, and then he hands the entire recording to their families...

...FOR FREE

So that 200 years from now, a great-great-grandchild will know not just their hero's name, but how he laughed, how he cried, and what he sacrificed.

Rishi has no military family, his parents immigrated here from India.

He does it out of pure gratitude.

In his words:

"My parents were given the opportunity to immigrate and raise a family because of veterans like these. It's a debt of love I'll spend my entire life trying to repay..."

As one 100-year-old Marine who stormed Iwo Jima told him, remembering the flag going up:

"The hair on my arms still stands up when I think about how beautiful it was."

THAT is America.

250 years of ordinary people doing extraordinary things...

God bless our veterans. 🇺🇸🇺🇸

[Stephen Estes @stephenestes1]

Couldn’t be more grateful to our Founding Fathers. It’s almost a glitch in the matrix that Franklin, Washington, Adams, Jefferson, Madison, and Hamilton (among others) were alive at the same time and place such that they’re were able to team up and defeat an empire — forging the most successful free and democratic society in the history of humanity. One that succeeded so profoundly it forged the highest standard of living this world has ever known.

May the light of liberty shine brightly for another 250 years, and beyond.

[Ethan Mollick @emollick]

Fable: "Last and First Men is out of copyright. I want you to make a movie that features a reading of it with appropriate mixes of animation and images using access to the APIs you have (elevenlabs, hugging face) . Give me the first 10-15 minutes, ending at an appropriate break."

[David Scott Patterson @davidpattersonx]

Garden cities coming soon.

People of the future will think it was strange that we lived with the noise, pollution, and danger of cars and trucks on open roads.

Just as we think it was strange that people of the past lived in clouds of coal smoke beside roads with open sewers.

In a few years, all cars will be autonomous and electric, and we will use unlimited robot labor to put all major roads underground.

Future cities will be quiet and safe.

Former roadways will be turned into pathways and playgrounds where children will play in perfect safety.

[Jesse Tinsley @JesseTinsley]

Imagine telling someone in 1999…

The year is 2026.

The President is Donald Trump in his second non consecutive term.

The richest man in the world is PayPal cofounder Elon Musk… but not because of fintech or Paypal. Because of rockets, electric cars, AI, satellites, brain chips and something called “Boring Company”.

Apple is worth trillions but its main business isn’t computers… its selling glass rectangles everyone stares at for 9 hours a day.

People don’t watch TV. They watch teenagers explain geopolitics, finance, and relationship advice in ~60 second videos.

The biggest taxi company owns no taxis.
The biggest hotel company owns no hotels.
The most powerful media companies are social networks where everyone argues with strangers for free.

Kids are making millions filming themselves playing video games.

AI Robots write emails, code, legal memos, songs, essays, and breakup texts.

The internet is mostly bots arguing with humans who are trying to prove they aren’t bots.

You can summon a car, groceries, a doctor, a date, a private jet, or a dog walker from your phone.

People pay real money for invisible currencies, digital monkeys, AI girlfriends and pictures that disappear after 24 hours.

The richest companies in the world don’t sell oil, steel, or cars. They sell attention, compute, data, and addiction.

And somehow, after all of that everyone is still using Excel.

[Ryan Shea @ryaneshea]

Wtf this is INSANE.

This is the first open source model from a US lab that codes at frontier levels.

The open source frontier no longer exclusively belongs to China.

The US is officially in the OS model race!

[Dr Singularity @Dr_Singularity]

Big bio/acc

NVIDIA is launching the BioNeMo Agent Toolkit - an open, agent ready toolkit that gives any AI agent callable tools for protein structure prediction, molecular docking, generative chemistry, genomic analysis, and more.

[Adams @Adams_Tech_AI]

I come to watch this whenever I feel lost.

[Peter H. Diamandis, MD @PeterDiamandis]

We are about to unlock a near infinite supply of resources in our solar system. The reality is an overwhelming amount of abundance. A near infinite supply of energy, metals, minerals and real estate. Abundance is our future, scarcity is our past.

[Stephen Estes @stephenestes1]

@KeepItFLOSSY @Kekius_Sage Statistically speaking this is 99% likely to be the case

[Stephen Estes @stephenestes1]

She not only has no political experience at all, but in fact has no real leadership experience whatsoever. She has never run a hot dog stand, a campaign, a government branch or office, nor has she held an executive position of any kind at any point in her life.

Somebody with this resume is unqualified to work in any position for any of my businesses.

And thus the modern left will likely vote for her in overwhelming numbers.

[Humble Flow @HumbleFlow]

You don't hate the mainstream media enough

You think you do, but you don't

[Beff (e/acc) @beffjezos]

Technology allows us to grow food without pesticides and support more healthy humans.

Another absolute win for the techno-capital machine.

Another L for Decels.

[cygaar @0xCygaar]

Greatest test of intelligence is asking someone what they think of Elon Musk

[Ole Lehmann @itsolelehmann]

it's insane to me that this isn't all over mainstream media right now.

for the first time in human history, a drug built to reverse aging was just put into a living person

a company called Life Biosciences dosed the first patient in their trial for something called ER-100

it comes from a Harvard geneticist named David Sinclair

his theory is that aging comes from your cells losing track of how to read their own DNA

think of it like a computer. the hardware is fine, but the software slowly gets corrupted over the years, so the machine runs slower and slower until it stops

the instructions for a young, healthy cell are all still in there. your cells just lost access to them over time

so this drug does one thing: it reboots the cell back to the version of itself that knew how to run properly

they pull it off with three proteins that reset a cell to a younger state

and they proved it works before ever touching a human

first they restored vision in old mice. then they restored vision in monkeys with optic nerve damage, with no tumors and no signs of harm

so now they're testing it on people going blind from glaucoma and a nerve condition called NAION

they started with the eye on purpose. it's the cleanest place to test the idea, because they can inject it into one eye without it reaching the rest of the body, the cells there don't heal on their own so any improvement clearly came from the drug, and they can measure vision right down to the letters on a chart

the reset happens at the level of the cell, so in theory the same approach could one day rejuvenate the liver, the kidneys, even the brain

it won't be automatic though. every organ needs its own way of getting the drug into the right cells, plus its own round of safety testing. so it doesn't suddenly work everywhere the moment it works in the eye

but the eye answers the one question nobody could answer before: whether you can safely turn back the age of living cells inside a person

if the answer is yes, reaching the rest of the body comes down to delivery, one organ at a time. that part is hard, but it's the kind of hard you can engineer your way through

to be clear, this is an early safety trial. 18 people, 5 year follow up.

so nobody is gonna cure aging by next year

but if it works, we'll look back at this week as the moment the clock started running backwards for the first time

[Pukar C. Hamal 🏔🗽 🌁 @pchamal]

Silicon Peaks is inevitable!

[Stephen Estes @stephenestes1]

@pchamal Awesome story!

[Adam Shuaib @adamshuaib]

The strongest predictor of who does extraordinary work is whether they ever obsessed over something pointless. We've seen this across 5000 startup meetings, but the pattern showed up across everyone from scientists to athletes.

We’ve met people who spent two years optimising their fantasy football algorithms, or memorised every player in the NBA at 11, or collected thousands of train tickets, or built a Lego replica of their school; none of these activities really had much point.

What they were demonstrating was the hardest skill in any field; the mental capacity to stay focused on a boring task for much longer than it deserves. The path to genius is mostly boring repetition, and people who achieve it have a broken off-switch. It is tough to fake having spent years obsessed with boring things that didn't matter.

[Benedict Spence @BenedictSpence]

What terrifies me about this attempted beheading is the potential backlash against peaceful beheaders.

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. I've held dying hearts in my hands in the cath lab at 3 AM. And I need to tell you something that changes everything about how we prevent heart attacks.

For decades, the entire field was built on one target: lower LDL cholesterol. Statins save lives — that's settled science. But too many of my patients did everything right — took their statins, hit their numbers, lived clean — and still ended up on my table with a ruptured artery.

We were treating the smoke while the fire kept burning.
The fire is inflammation. And the evidence is now overwhelming.

The CANTOS trial proved it first — lowering inflammation independent of cholesterol reduced cardiac events. But the newer data is what keeps me up at night.

AI-enhanced CT angiography can now detect inflamed arteries by measuring changes in the fat surrounding your coronary vessels — the perivascular fat attenuation index. Higher inflammation in the fat around even one artery independently predicts cardiac death. When multiple arteries show inflammation, the risk multiplies dramatically — even in patients whose cholesterol looks perfect.

This isn't theoretical. This is measurable. Right now. On a scan you can get this month.

Low-dose colchicine — a drug that's been around for centuries for gout — is now FDA-approved specifically for reducing cardiovascular events. It works by quieting the inflammatory cascade that destabilizes the plaque sitting in your arteries. A pill that costs pennies is saving lives the statins couldn't reach.

And the next wave is already in Phase 3 trials. Ziltivekimab — an IL-6 inhibitor — targets the central inflammatory pathway driving atherosclerosis. Phase 2 data showed a 90% reduction in hsCRP. The ZEUS cardiovascular outcomes trial is enrolling now, with results expected late 2026 into 2027. If positive, anti-inflammatory therapy will become standard in managing heart disease alongside lipid-lowering. The era of inflammation-targeted cardiology is arriving.
But it goes deeper than drugs. AI is now predicting heart failure and cardiac events 5+ years before symptoms — integrating CT imaging, electronic health records, and genetic data with accuracy that jumps far beyond traditional risk calculators.

And polygenic risk scores — a simple genetic test that flags inherited cardiovascular risk — are now formally recognized as a risk-enhancing factor in the 2026 ACC/AHA guidelines. A single blood draw can reveal risk that's been silently building since birth. Decades before the first chest pain.

Here's what this means for you right now — today:
Ask your doctor for a high-sensitivity CRP test. It's cheap, routine, and measures the systemic inflammation that standard cholesterol panels completely miss. You can have perfect LDL and inflamed arteries that are quietly preparing to rupture.
If your hsCRP is elevated, discuss low-dose colchicine with your physician. It's FDA-approved for exactly this.
Push for a coronary CT angiography with AI plaque and inflammation analysis if you have risk factors. This isn't the stress test your parents got. This is 3D visualization of your actual arteries — with AI quantifying not just how much plaque you have, but what kind it is and whether the surrounding tissue is inflamed.
Consider polygenic risk score testing — especially with a family history of early heart disease. It's now guideline-supported.

And the foundation that never changes: move daily, eat real food, sleep 7-9 hours, manage stress, and know your numbers — ApoB, Lp(a), hsCRP, fasting insulin.
I left Iran as a child with nothing. I rebuilt everything in a country that gave me the freedom to become a physician. I've spent twenty years watching patients get second chances.

The ones who haunt me aren't the ones who died on my table. They're the ones who survived but never acted on what the science was telling them — years before the event that didn't have to happen.

You can have perfect cholesterol and still have a heart attack. Inflammation plus genetics can drive plaque rupture in arteries that look "fine" on a standard panel.
The myth that normal cholesterol means you're safe has cost more lives than I can count.

We now have the tools to detect the fire — not just the smoke. AI to see it. Genetics to predict it. Drugs to quiet it. And the ancient basics — movement, real food, sleep, purpose — to prevent it from starting.

Prevention is the new cure. And the science to make it real is no longer coming.
It's here.