Topoisomerase inhibitors
🦋Topoisomerase I (one per -can)
~ prevents relaxat1on of supercoiled DNA.
(Examples: topotecan, irinotecan, belotecan)
🦋Topoisomerase II (two the -side)
~ prevents reco1L1ng of DNA after transcription.
(Examples: eTWOposide, tenoposide)
✿ reactivity series - most reactive > least reactive
Kain (K) NA (Na) CA (Ca) ! Mag (Mg) ALmusal (Al) sa Car (C). Zinabi (Zn) ni Fe (Fe) San (Sn) Paba (Pb) ? Hay (H) naCU (Cu) ! SIge (Silver - Ag) Go (Gold - Au)
K > Na > Ca > Mg > Al > C > Zn > Fe > Sn > Pb > H > Cu > Ag > Au