Our new preprint is out! We use stochastic genotype landscapes to predict the shape of evolutionary trade-off functions, and test what happens when you use this as the basis of a mutation-selection model.
Having negative resistance transitivity means that a host population maintains individuals which are more susceptible to foreign pathogens than endemic, opening an ecological niche for spillover pathogens to invade. 6/
Our new paper on host-pathogen coevolution and spillover (as seen at EEID and Evolution) just came out in evolution letters! 1/
https://t.co/QFGYkqD07C
However, there is a catch! When the loci underlying general and specific resistance become linked, this positively correlated resistance transitivity can switch to negative. When we let linkage evolve, tight linkage between general and specific resistance is favored. 5/
Specific resistance prevents the #evolution of general resistance and facilitates #diseaseemergence#openaccess
Hulse et al. @MEHood_AC
๐https://t.co/iXGyT0CkJq
@wmataGM Absolutely a real comparison. Transit makes good cities possible. Hundreds of thousands rely on public transit daily, hard to find any other service quite like that.