Tapsi Kumar, PhD

BMS | ExChair - Scholarships @Awis_Houston | PHD @MDAndersonNews. Single cell genomics | Computational Biologist | Oncology. Crazy animal (-reptile) lover.

[Raffaele Colombo @raffcolo]

Iza-Bren is very effective (not only in TNBC) but its profile is also very chemo-like.

What’s the targeted contribution vs non-specific uptake? Iza-Bren half-life is ~1 day!

What’s the correlation with EGFR expression? HER3 expression? Co-expression of both EGFR and HER3?

[Kazuki Nozawa, MD @kazuki_nozawa]

ビッグニュースが舞い込んできました！

FDAでHER2陽性早期乳がんに対するエンハーツ(トラスツズマブ　デルクステカン)が承認されました。
しかも、DB-11試験に基づく術前ハイリスク集団と、DB-05試験に基づく術後残存病変を有する集団の、両方に対して一気に適応されます。
同じように、日本での承認が待たれます。果たして術前も同時に承認されるのか���ポイントになります。

https://t.co/NluP2HDve8

[Nature Portfolio @NaturePortfolio]

A study in Nature reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems that can be accessed non-invasively via liquid biopsy and used to profile individual cancers and target treatments. https://t.co/3ajlUIxq1B

[Neo Kim @systemdesignone]

If you're serious about AI engineering (in 2026), then learn these 13 concepts:

1 How Vector Database Works
→ https://t.co/FVxan8xHH3

2 How RAG Works
→ https://t.co/cGmunPTUlb

3 Design Personal Chat Assistant
→ https://t.co/nNWq3onTnW

4 LLM Concepts - A Deep Dive
→ https://t.co/5lCKxq2g4N

5 How to Design an AI Agent
→ https://t.co/JvnPd9773A

6 What is Reinforcement Learning
→ https://t.co/AVpl9j1oit

7 LLM Evals 101
→ https://t.co/nv3Ol8W53p

8 Context Engineering 101
→ https://t.co/OMkiZhkODL

9 AI Coding Workflow 101
→ https://t.co/paIf9ksIU9

10 Agentic Patterns, Simply Explained
→ https://t.co/8YdBBWvTj1

11 How AI Agents Work
→ https://t.co/tk3zkCjRvg

12 Multi-Agent Architectures, Clearly Explained
→ https://t.co/rS5QQS7Jln

13 How MCP Works
→ https://t.co/wgf8gHnnkn

What else should make this list?

===

👋 PS - Want my System Design Playbook (for Free)?

Join my newsletter with 200K+ software engineers now:
→ https://t.co/ByOFTtOihX

===

💾 Save now & repost to help others learn AI engineering.
👤 Follow @systemdesignone + turn on notifications.

[Diego A. Díaz-García @diegoadiazg]

🫁 MTAP deletions in NSCLC and EGFR.

MTAP del in 10% (n=4926). In stage IV, 83% co-occurred with drivers; EGFR in 48%.

Shorter time to osimertinib discontinuation (19.0 vs 24.9 mo; HR 1.8; p=0.01). No significant OS difference.

Acquired MTAP del at resistance in 13%. Signal of activity with PRMT5 inhibition (BMS-986504).

📖 @JTOonline
DOI 👉🏻 https://t.co/4LuC6kjlur

#CánCare #NSCLC #EGFR #biomarkers #targetedtherapy #lcsm

[Nav Toor @heynavtoor]

Claude can now teach your kids any school subject like a $100/hour private tutor from Khan Academy. For free.

Here are 12 prompts that explain math, science, history, and English at any grade level in minutes:

(Save this before it disappears)

[Anirban Maitra @Aiims1742]

What a time to be alive when I have to choose between attending Brian Wolpin’s talk on Daraxonrasib + chemo in 1st line #PancreaticCancer OR @RevMedicines talk on their preclinical asset RM-055 that overcomes KRAS inhibitor resistance, BOTH at the exact same time!
#AACR26

[🧬Laboratory Information @HA_Laboratory]

🔷Human Immune Cell Marker Guide 🩸🩸

#cellsignaling

[Naoto T Ueno, MD, PhD @teamoncology]

Our new ADC review provides a different perspective on why ADC resistance occurs and how we can address it.
https://t.co/R03aNOgAv1

[Eric Topol @EricTopol]

Cancer immunotherapy keeps revving up. Now onto a 3rd generation of T cell engagers
https://t.co/h05f8h3i8L

[Raffaele Colombo @raffcolo]

More than 430 abstracts on ADCs at #AACR26!

⬆️ Largely dominated by TOPO1i ADCs and bispecific ADCs

↗️ Dual payload ADCs are growing (36 abstracts)

↘️ Degrader Antibody Conjugates (DACs) not so much (12 abstracts)

⬇️ Limited novel ADC payload classes (<15 abstracts)

[Roan @RohOnChain]

This 2 hour Stanford lecture shows exactly how Stanford trains it's engineers to build AI systems. It's more practical than every Claude tutorial & prompting threads you've seen.

Bookmark & give it 2 hours, no matter what. It'll be the most productive thing you do this weekend.

[Kai @bmassutis]

Antibody Drug Conjugates ADCs toxicities are complex and need to be actively addressed #ELCC

[Ming "Tommy" Tang @tangming2005]

Claude Chat vs Cowork vs Code Tab vs Code CLI — what's actually different?

I used Claude Code to fact-checked every feature against official Anthropic docs and put together this comparison table.

[Nav Toor @heynavtoor]

BREAKING: AI can now analyze any stock like a Wall Street analyst (for free).

Here are 10 insane Claude prompts that replace $2,000/month Bloomberg terminals (Save for later)

[Vivek Subbiah, MD @VivekSubbiah]

Wow! Cool--> #PrecisionMedicine in action 👉Individualized mRNA vaccines evoke durable T cell immunity in adjuvant Triple-negative breast cancer #TNBC @@Nature @OncoAlert
👉Individualized neoantigen mRNA vaccine in 14 patients with TNBC following surgery and after neoadjuvant or adjuvant therapy
👉11/14 patients remained relapse-free for up to six years post-vaccination.
https://t.co/tLOTIBVQs3

[Nav Toor @heynavtoor]

🚨BREAKING: Claude is insane for market research.

I reverse-engineered how top consultants at McKinsey, Goldman Sachs, & JP Morgan use it.

The difference is night and day.

Here are 12 insane Claude Opus 4.6 prompts they don't want you to know (Save for later)

[Prof Jeffrey S Morris @jsm2334]

Important information to keep in mind.

AI is an incredible tool to supplement your work but don’t use it as a substitute for thinking for yourself .. or you atrophy the parts of your brain used for thinking for yourself.

[Python Programming @PythonPr]

Top 5 Types of AI Agents!

[Naoto T Ueno, MD, PhD @teamoncology]

Tumors resistant to one ADC can regain sensitivity to another ADC with a different payload.
Our work shows payload choice—not just target expression—may extend clinical benefit in breast cancer. No evidence that sequential of FDA approved drugs are beneficial in the clinical setting.

https://t.co/WOquXHML7i