Tim Chlon

PhD molecular biologist with expertise in hematology @CincyChildrens. Outside of lab, I am a father, husband, sports coach, and scout leader. Views are my own.

[Tim Chlon @tchlon]

@StXTigersBKB Update?

[Tim Chlon @tchlon]

@rosslevinemd Congratulations! Sounds like the perfect role for your transformational leadership!

[Tim Chlon @tchlon]

@lane_andy Not at all, unfortunately.

[Nick Mark MD @nickmmark]

🚨Apparently all NIH Study Sections have been suspended indefinitely.

For those who don’t know, this means there won’t be any review of grants submitted to NIH

Depending on how long this goes on for, this could lead to an interruption in billions in research funding.

[Tim Chlon @tchlon]

@CarmeloGurnari @Roma @TheEBMT @MDSFoundation @aamdsif @TheEBMT_Trainee Merry Christmas mi amigo! Many blessing to you and all fighting the good fight for the patients today and always

[Tim Chlon @tchlon]

And thank you to @CarmeloGurnari for the photos

[Tim Chlon @tchlon]

It never gets old - getting on the stage at ASH to present my lab’s work is a thrill that I have had the pleasure to live again. #ASH24

[Tim Chlon @tchlon]

@CarmeloGurnari This compliment means the world. The same can be said for you on the clinical side. Thank you for your support and friendship!

[Tim Chlon @tchlon]

@bloodgenes @Hema_News @RichardVoit @CellStemCell Congratulations Vijay and Richard! Such a cool story and hopefully impactful for patients in the near future!

[Tim Chlon @tchlon]

@SamuelJohnTayl1 Congratulations Sam! A lot of blood, sweat, and tears mixed in with remarkable ingenuity and skill went into this I am sure.

[Tim Chlon @tchlon]

@leonard_zon Beautiful work! Congratulations to Cecilia, Len and the entire team!

[Tim Chlon @tchlon]

We celebrated the second annual Chlon lab summer party this evening. It is a highlight of my summer to enjoy the company of the whole group and their families together in my backyard. I am so lucky to have such an amazing group working with me.

[Tim Chlon @tchlon]

@Krauselab_Yale @YaleCCEH @Yale_LabMed @NKwonHem Congratulations!

[Hematopoiesis News @Hema_News]

Dr. Emily Stepanchick from the Chlon lab (@tchlon) at @CincyChildrens led this study showing that DDX41 haploinsufficiency causes inefficient #hematopoiesis under stress ⚡ and cooperates with p53 mutations to cause hematologic malignancy.

👉 https://t.co/tMONPYq460

[Tim Chlon @tchlon]

The paper is entitled “DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 malignancy to cause hematologic malignancy”

[Tim Chlon @tchlon]

I am proud to present my lab’s first research paper, published online in @LeukemiaJnl today! Check it out https://t.co/T3TNpQEru2
Congrats to first author Emily Stepanchick!

[Tim Chlon @tchlon]

Also thanks to my entire team for their contributions and to @dstarczynowski for his support and mentorship on the project.

[Tim Chlon @tchlon]

Mechanistically, we find that Ddx41-het progenitor cells have activated cellular stress signaling pathways, including the p53 and cFos/Jun signaling. Innate immune signaling is also observed.

[Tim Chlon @tchlon]

Heterozygosity for p53 rescues the HSPC defects and reduces cell stress signaling but leaves innate immune activation in place. Combined Ddx41/p53 heterozygosity results in a highly penetrant, often fatal hem malignancy, modeling aspects of the patient disease.

[Tim Chlon @tchlon]

We show that heterozygous loss of DDX41, which models patients with germline predisposition to MDS/AML, causes hematopoietic stem and progenitor cell defects under conditions of stress. The erythroid lineage is particularly affected, resulting in mild anemia.