Herra Grajo Mendoza

PhD Candidate in Chemistry & Chemical Biology (Beal Lab), UC Davis | studies RNA editing by ADARs

[Herra Grajo Mendoza @thequeenjuno]

I’m deeply honored to have represented in this work the multiple talented previous and current members of the Beal lab and our collaborators. Special thanks to my PI, @peterabeal, for his guidance and support throughout my PhD at UC Davis and for the writing of this manuscript!

[Herra Grajo Mendoza @thequeenjuno]

Capping off my PhD with this Accounts article on our lab’s use of chemically modified oligonucleotides to illuminate the ADAR structure and substrate recognition and modulate its activity for site-directed RNA editing applications and inhibitor design.

https://t.co/lvAjmqo0Up

[UC Davis Biotechnology Program @UCDavisBiotech]

Check out the new blog/explainer on RNA-based therapeutics by @thequeenjuno 👩🏻‍🔬 https://t.co/VndnHryxDK

[Herra Grajo Mendoza @thequeenjuno]

This work wouldn’t be possible without the support and guidance of my PI, @peterabeal, and my present and former labmates, @jauregvic, @1211spark, and @kev_m_ph. Congratulations, everyone! 🧬

[Herra Grajo Mendoza @thequeenjuno]

I’m excited to share our work on the utilization of a chemically modified RNA duplex for ADAR1-selective inhibition and gaining deeper insight into substrate recognition by ADAR1.

https://t.co/fz6O0hroLv

[Herra Grajo Mendoza @thequeenjuno]

where guide oligonucleotides are used to recruit endogenous ADARs to correct disease-causing mutations in the transcript. This study lays the groundwork for the design of potent and specific modulators of ADAR1.

[Herra Grajo Mendoza @thequeenjuno]

@xewilcox Feel better, Xander!

[Herra Grajo Mendoza @thequeenjuno]

@Aliciaadv @rociosotillo @SotilloLab @HarrisLabUMN Congratulations, Alicia! Happy for you!!!

[Herra Grajo Mendoza @thequeenjuno]

@xewilcox I’m so sorry, Xander. You are one of the most passionate researchers I know, and it’s just sad not to see you continue. But I think that there’s no need to rush to get back. You’ve been through a lot and you should take your time to recuperate and come back even stronger.

[Jen Heemstra @jenheemstra]

Next time you're in a room (real or virtual) with a bunch of people who you look up to, take a moment to stop, look around, and remind yourself "I belong here."

[Herra Grajo Mendoza @thequeenjuno]

@rollfeedoodle Gets ko naman, pero nagutom ako sa handa 😂

[Herra Grajo Mendoza @thequeenjuno]

And there’s my pink Cy3-labeled oligo that I synthesized and posted about a while ago! These are actually brain cells that I transfected, stained, and viewed under a fluorescence microscope. My oligos are the pink dots against the green (cytoplasm) and blue (nucleus) background.

[Herra Grajo Mendoza @thequeenjuno]

@JoannaAniago Not personally. But I have a few friends who worked/are working for her and she’s also pretty known in her field!

[Herra Grajo Mendoza @thequeenjuno]

“I felt that chemistry would explain the diversity of materials and substances in the natural world in a way that Physics would not...” #DEB263 https://t.co/Nxr6F2SRfk

[Herra Grajo Mendoza @thequeenjuno]

Achievement unlocked. First time presenting my research in an international setting. It was an honor to meet and talk about my work with some pioneers and experts in the base editing field and hear about some really cool science! #Deaminet2022

[UC Davis @ucdavis]

Join us, @Chancellor_May @Renetta_Tull to take a moment of silence for #GeorgeFloyd, #BreonnaTaylor, #AhmaudArbery & many others such #StephonClark, & to mourn for injustice. We will affirm our support for Black lives, acknowledge racism & our commitment to address it.

[Herra Grajo Mendoza @thequeenjuno]

First human trial results raise hopes for coronavirus vaccine https://t.co/IzUrdjPRZU

[Herra Grajo Mendoza @thequeenjuno]

The Beal lab’s crystal “structure or ADAR bound to double-stranded RNA made the system more understandable and enabled scientists to better engineer the enzyme to enhance its delivery or make it more efficient.” #DEB263 https://t.co/ocdxXewVCb

[Herra Grajo Mendoza @thequeenjuno]

Hard to imagine that this cute little axolotl has 10x larger genome than humans and may hold the key to effective damaged tissue repair/regeneration in humans. #DEB263
https://t.co/cLj3XS0cpX

[Herra Grajo Mendoza @thequeenjuno]

How true 😅