Therina du Toit

Steroid biochemistry | 11Oxy steroids | Mass spectrometry

[PANDEY LAB 💊🧫🔬🥼⚛💻 🇨🇭 @Pandeylab]

This is a total game-changer for endocrinology! Groundbreaking research with major impact. So incredibly well-deserved! 🎉🔬

#PORdeficiency #Endocrinology #ScienceWin #AwardWinner #UniversityOfBern #FutureIsBright #WomenInSTEM

[PANDEY LAB 💊🧫🔬🥼⚛💻 🇨🇭 @Pandeylab]

Lap party of Translational Hormone Research Program of @DBMR_UniBe of @uniofbern including @Pandeylab Flueck Lab and du Toit lab members.

[Maddalena Tognola @Maddalenabern]

#MSCA fellow @adrijeckel presenting her research on the enzyme of a larvae that manages to eat the roots of maize. #NdFunibern

[Maddalena Tognola @Maddalenabern]

#NdFunibern with @therina_dutoit presenting her #MSCA project on foetal signalling molecules.

[Maddalena Tognola @Maddalenabern]

Kick-off mit the #MSCAFellows at #NdFunibern. Speed dating with Agne Frismantiene of @PertzL presenting her project on cancer cells which are as diverse as snow flakes.

[Universität Bern @unibern]

Congratulations to the seven researches who are visiting #unibern this year as Marie Skłodowska-Curie Fellows @MSCActions via @REA_research ! https://t.co/h9XuGYs53I #MSCA #IF @EU_Commission @adrijeckel @therina_dutoit @fpoeppelmeier

[Therina du Toit @therina_dutoit]

@ASBMB Thank you @ASBMB for this twitter questionnaire and the opportunity to share our research! #ASBMBposters #ASBMBenzymes

[Therina du Toit @therina_dutoit]

@ASBMB And the contribution of the C11-oxy steroids in maintaining homeostasis via the endocrine system has not been elucidated. #ASBMBposters #ASBMBenzymes

[Therina du Toit @therina_dutoit]

@ASBMB Also, the role of the C11-oxy steroids have yet to be fully explored in normal physiology. #ASBMBposters #ASBMBenzymes

[Therina du Toit @therina_dutoit]

@ASBMB ―11βHSD1 & 11βHSD2 does not only catalyse the interconversion of cortisol and cortisone. #ASBMBposters #ASBMBenzymes

[Therina du Toit @therina_dutoit]

@ASBMB ―CYP11B1 & CYP11B2 does not only catalyse the production of cortisol and aldosterone. #ASBMBposters #ASBMBenzymes

[Therina du Toit @therina_dutoit]

@ASBMB Our UPC2-MS/MS methods showcase how we identify all the C11-oxy steroids using mass spectrometry; https://t.co/sgBcePCrof, https://t.co/h6JtId2P8i #ASBMBposters #ASBMBenzymes

[Therina du Toit @therina_dutoit]

@ASBMB UPC2-MS/MS methods were developed and validated to identify & quantify all steroids, some of which had to be prepared or custom synthesized. #ASBMBposters #ASBMBenzymes

[Therina du Toit @therina_dutoit]

@ASBMB And all of these C11-oxy steroids we were investigating were not commercially available. #ASBMBposters #ASBMBenzymes

[Therina du Toit @therina_dutoit]

@ASBMB A3: Some of the C11-oxy steroid products formed in the reactions are novel, difficult to analyse, identify and quantify. #ASBMBposters #ASBMBenzymes

[Therina du Toit @therina_dutoit]

@ASBMB For LNCaP data, please see https://t.co/yN2uxbr4l8 #ASBMBposter #ASBMBenzymes

[Therina du Toit @therina_dutoit]

@ASBMB We also assayed the conversion of 11-hydroxyprogesterone & 11keto-progesterone by endogenous steroidogenic enzymes, 11βHSD2 & CYP17A1, in LNCaP cells. #ASBMBposters #ASBMBenzymes