Tirth Patel

MD/PhD student @WUSTL/ Neurodegeneration/ Budding neurologist

[Tirth Patel @tkpwustl]

@Schultz_SA @MillerLabNeuro @WUSTLmed @WUSTLdbbs Whoa just landed at LAX and opened twitter to find this. Congrats to all the winners! #ANA2019

[Tirth Patel @tkpwustl]

Stunning backdrop for the #ANA2019 President’s reception

[Tirth Patel @tkpwustl]

Dr Erik Musiek @ErikMusiek underscores the link between circadian rhythm, neurodegeneration and neuroinflammation: Chi3L1/YKL-40 a known AD biomarker, is regulated by the circadian clock, modulates astrocyte activation and amyloid plaque accumulation in mouse models #ANA2019

[Tirth Patel @tkpwustl]

Using the prairie vole as a model for complex interactions between REM sleep and socialization her group found that sleep disruption in voles affects their partner preference, and increases aggression in males #ANA2019

[Tirth Patel @tkpwustl]

Dr Miranda Lim makes the compelling argument that sleep disturbances and anomalies in children with autism may be key causal features rather than being mere symptoms of the disorder #ANA2019

[Tirth Patel @tkpwustl]

@NorthwesternU These circadian patients may perhaps require non-light based approaches to treating their disorder #ANA2019

[Tirth Patel @tkpwustl]

Dr Sandra Abbott kicking off the 'Sleep disorders and circadian rhythms' session with the fascinating story of starting and growing a circadian medicine clinic at @NorthwesternU

[Tirth Patel @tkpwustl]

@NorthwesternU There is a segment of the population that appears to be visually normal but 'blind' to circadian effects of light #ANA2019

[Tirth Patel @tkpwustl]

It all starts by mapping fundamental neural circuits to create a human connectome and link brain lesions to clinical symptoms #ANA2019

[Tirth Patel @tkpwustl]

Dr Michael Fox, one of the 2019 Derek Denny-Brown awardees, tracing his path to success, starting from his academic roots right here @WUSTLmed #ANA2019

[Tirth Patel @tkpwustl]

Deep brain stimulation is responsible for remarkable success stories across a wide array of neurological and neuropsychiatric diseases #ANA2019

[Tirth Patel @tkpwustl]

@Schultz_SA’s excellent data blitz talk reveals a strong correlation between decreased white matter integrity and elevated levels of neurofilament light protein #ANA2019

[Tirth Patel @tkpwustl]

Increases in amyloid-beta load precede a sharp (almost vertical!) rise in tau load in genetic carriers for AD per Dr Quiroz’s data packed talk #ANA2019

[Tirth Patel @tkpwustl]

Amyloid and tau PET provide excellent correlation with plasma levels of amyloid-beta and tau #ANA2019

[Tirth Patel @tkpwustl]

“Like real estate, with tau it’s location location location” - Dr Rabinovici, on the critical correlation between tau deposition in different brain regions and cognitive deficits #ANA2019

[Tirth Patel @tkpwustl]

Synergy between amyloid and tau drives tau spreading, neurodegeneration and consequently, dementia #ANA2019

[Tirth Patel @tkpwustl]

AD risk alleles are enriched in enhancer regions of myeloid cells and CNS microglia #ANA2019

[Tirth Patel @tkpwustl]

Presidential symposium on latest breakthroughs in treatments of Alzheimer’s disease about to begin! #ANA2019

[Tirth Patel @tkpwustl]

Strikingly 3-4% of sporadic Alzheimer’s patients harbor mutations in APP, PSEN1/2, which havw traditionally been associated with early onset AD #ANA2019