Luo Yun

PhD candidate of Wuhan University

[Luo Yun @tomluoyun]

Excited to share our new publication in @J_A_C_S, wherein formal carbonyl insertion was achieved at the para or ortho position of pyridines, enabling access to 1,4- or 1,2-azepinones, which could be smoothly downstreamed into bicyclic pyrrolidinones. https://t.co/6tJtWm8R3K

[Max Verstappen @Max33Verstappen]

Feels good to be battling up front again and taking that first podium of the season 🙌

[Luo Yun @tomluoyun]

Excited to share our new publication in @J_A_C_S, wherein formal carbonyl insertion was achieved at the para or ortho position of pyridines, enabling access to 1,4- or 1,2-azepinones, which could be smoothly downstreamed into bicyclic pyrrolidinones. https://t.co/6tJtWm8R3K

[J. Am. Chem. Soc. @J_A_C_S]

Divergent Skeletal Editing of Pyridinium Salts to Azepinones and Pyrrolidinones via Formal Carbonyl Insertion | Journal of the American Chemical Society https://t.co/gM8nLeYNou

[DeepSeek @deepseek_ai]

🚀 DeepSeek-V4 Preview is officially live & open-sourced! Welcome to the era of cost-effective 1M context length.

🔹 DeepSeek-V4-Pro: 1.6T total / 49B active params. Performance rivaling the world's top closed-source models.
🔹 DeepSeek-V4-Flash: 284B total / 13B active params. Your fast, efficient, and economical choice.

Try it now at https://t.co/GCdiMzk1Dl via Expert Mode / Instant Mode. API is updated & available today!

📄 Tech Report: https://t.co/drlDrxkYtp
🤗 Open Weights: https://t.co/T13Y8i7SDM

1/n

[Sho Murakami @sulfurchemistry]

Excited to share our latest work is now out on @J_A_C_S !!!!

We report a visible-light-driven platform for alkyl radical generation from redox-inert substrates based on photo-active sulfur-intermediates formed via polar activation.

https://t.co/4wMM3haOXD

[J. Am. Chem. Soc. @J_A_C_S]

One-Step-Three-Ring Propellanation Reaction of Yne-Vinylcyclobutanones Catalyzed by Nickel: Reaction Development, Mechanism, and Formal Synthesis of Modhephene | Journal of the American Chemical Society https://t.co/WSlEZhZsLF

[Luo Yun @tomluoyun]

Excited to share that our pyridine → aniline skeletal editing work is now a Cover Feature in ChemistryEurope. Thanks to everyone for the support!
Free to read: https://t.co/xc8QoXvo0T

[ChemistryEur @ChemistryEur]

Indeed, No Need for HMPA! A DFT Study Comparing the Lewis Basicity of Phosphoric Acid Triamides by Luca Steiner, Hans-Ulrich Reissig, and co-workers (Freie Universität Berlin) #OpenAccess
https://t.co/qabaFbdWQ7

[Nature Catalysis @NatureCatalysis]

Excited-state configuration controls the ability of nitroarenes to act as energy transfer catalysts https://t.co/sAYz3g2GNy

[Luo Yun @tomluoyun]

@AsAshraf123321 @ChemistryEur Thank you!

[Luo Yun @tomluoyun]

🚀Our pyridine → aniline #SkeletalEditing paper is now #1 Most Accessed article (past 3 months) in @ChemistryEur
📈 Over 1,000+ full-text views in just 20 days. A huge thanks to the community for the incredible interest and support!
🔗 Free to read:
https://t.co/xc8QoXvo0T

[ChemistryEur @ChemistryEur]

Skeletal Editing from Pyridine to Aniline via C-Insertion and N-Isomerization by Yun Luo, Jing Dai, Yongchang Wei, and Chang Min (Wuhan University) #OpenAccess 🔓 https://t.co/1J63lZs2rO

[Luo Yun @tomluoyun]

💡Powered by our pyridine-to-aniline skeletal editing, drug candidate Rogletimide can be directly converted into the approved💊Aminoglutethimide—a therapy for Cushing’s syndrome.
#SkeletalEditing accelerates #DrugDiscovery process.
🔗Free to read:
https://t.co/xc8QoXuQbl

[Luo Yun @tomluoyun]

Free to read link here: https://t.co/xc8QoXvo0T

[Luo Yun @tomluoyun]

One-Step #SkeletalEditing: Pyridine → Aniline

500+ Full Views in first 10 days📈
Featured in "Editor's Choice"

Huge thanks to my advisor Chang Min.

Thank @ChemistryEur @ChemEurope @angew_chem
for sharing our work!

🔗Free to read link in the first reply below 👇

[Luo Yun @tomluoyun]

@ChemistryEur Thanks for promotion!

[Luo Yun @tomluoyun]

A powerful example: using our pyridine-to-aniline skeletal editing, the drug candidate Glutethimide can be directly converted into the approved 💊 Aminoglutethimide—a therapy for Cushing’s syndrome. #DrugDiscovery
Skeletal editing accelerates drug discovery process.

[ChemistryEur @ChemistryEur]

Skeletal Editing from Pyridine to Aniline via C-Insertion and N-Isomerization by Yun Luo, Jing Dai, Yongchang Wei, and Chang Min (Wuhan University) #OpenAccess 🔓 https://t.co/1J63lZs2rO

[Luo Yun @tomluoyun]

Our new paper is out now in @ChemistryEur. In this work, we introduce a sequential Carbon-insertion and Nitrogen-externalization strategy enabling the pyridine-to-aniline conversion in one single step.
#SkeletalEditing #OrganicChemistry
https://t.co/A37mhbAwWX

[Luo Yun @tomluoyun]

great job max! phenomenonal performance

[Formula 1 @F1]

FROM THE PIT LANE TO P3 FOR MAX!!!

Even by @Max33Verstappen's standards that was a simply incredible performance 💪

#F1 #BrazilGP