Excited to share my first postdoc work co-led with Yuichi Chayama, from @andcyang lab - now out in @CellCellPress! We created a genetic system to trace how the brain clears waste, uncovering surprising new biology about waste clearance pathways. 🧵1/9
🔗 https://t.co/1s7AcXZcv4
Our live tissue clearing paper is out in @naturemethods! We achieved optical clearing of mammalian brain tissues without compromising normal neuronal function. Big congrats to @Shigenori774 and our wonderful collaborators! 🎉
https://t.co/joMB5odihK (1/10)
Most transcriptomics studies sample ~0.001% of a mouse. Which region to choose? Often we guess.
We introduce DISCO-seq🤗flipping the order:
Whole-body 3D imaging with RNA-preserving clearing→ pick ROIs in 3D→ unbiased scRNAseq
Led by @HarsharanBhatia
https://t.co/kYkzAWC5K9
#PR Our Ms on brain atlas of circadian activity is out in Science! ~80%(508 regions) of whole brain show significant oscillations. We envisioned it at first CUBIC papers in 2014. It took a decade. Congrats, Katsu&Fukuaki! Ms→https://t.co/VZNUIEsHbm
DB→https://t.co/01evod4ChG
The Lipid Brain Atlas is out now! If you think lipids are boring and membranes are all
the same, prepare to be surprised. Led by Luca Fusar Bassini with Gioele La Manno's lab, we mapped membrane lipids in the mouse brain at high resolution.
https://t.co/q3AeqGsIS1