Train2Target

T2T is a Marie Skłodowska-Curie Action ITN dedicated to finding a new generation of antibiotics targeting the bacterial cell envelope. #H2020 #MSCA

[Vincent Trebosc @V_Trebosc]

Interested in #drugdiscovery #pathogenesis and #Acinetobacter baumannii? Have a look at our OmpR-targeted anti-virulence drug development approach. Great collaborative effort @Bioversys @biozentrum @psich_en @aptuit @_BioSystems @Train2Target
https://t.co/neccHw4reT

[Train2Target @Train2Target]

Happy to announce this new publication about mNeonGreen 💚 and sfTq2ox 💙 expression in the cytoplasm of E. coli.

Congratulations to the authors @TannekedenBlaau and @LaureenMertens from @SILS_UvA !

https://t.co/jWSoSrF0th

[Train2Target @Train2Target]

We are proud to share the latest @train2target paper from our #ESR Federico Corona

In this paper, the authors explore the crosstalk between #OMP biogenesis and #peptidoglycan maturation

Congratulations to al the authors!! Vollmer lab @KleanthousLab

https://t.co/1DkN62cxbl

[Train2Target @Train2Target]

The peptidoglycan of Akkermansia contains non-acetylated glucosamine (GlcNH2) which has not been described as a major component of gram-negative PG before!

It activates NOD1 & NOD2 receptors leading to a similar immune response as to E. coli.

[Train2Target @Train2Target]

Happy to share another @Train2Target paper!

In this paper, the authors challenge the hypothesis of how #peptidoglycan triggers the #immunesystem.

Congratulations to all the authors! 👏
@PilarGVello @HanneTytgat @MolinaroTony @cribilla68 @UninaIT @WUR

https://t.co/DoSO0QT6dv

[Train2Target @Train2Target]

We are proud of @Train2Target's Carina Matias (@CarinaSofiaM) contributions to this paper!

The paper explores the potential of topical niclosamide ATx201 as a decolonizing agent.

Congratulations to all the authors 👏👏

https://t.co/XgIJ75zyJ4

[Train2Target @Train2Target]

We're very happy to showcase this work by
@Train2Target's Elisa Consoli, @TannekedenBlaau'wen
and their collaborator Joen Luirink. 👏👏👏

'The Escherichia coli Outer Membrane β-Barrel Assembly Machinery (BAM) Crosstalks with the Divisome.'

https://t.co/fY3L58QErb

[Train2Target @Train2Target]

Proud to share this publication by @Train2Target ESRs @TiagoBaeta7, Elisabete Moura and their colleagues.

The lipopolysaccharide transporter complex LptB2FG also displays adenylate kinase activity in vitro dependent on binding partners LptC/LptA

https://t.co/47HGrolmqG

[Pilar Garcia-Vello @PilarGVello]

Lipopolysaccharide lipid A: a promising molecule for new immunity-based therapies and antibiotics 🦠🔬
Always thanks to @MolinaroTony @cribilla68 @di_flaviana
#AMR #vaccination #microbiome #diabetes #inflammation
#ScienceReview #ScienceTwitter #Science
https://t.co/YA9Hcr2Waj

[Pilar Garcia-Vello @PilarGVello]

Oral admin of pasteurised Akkermansia muciniphila is safe, the European Authority of Food Safety @EFSA_EU said!
This is a crucial step towards new generation nutritional supplements to treat #diabetes and other metabolic diseases.
It's also part of my PhD!
https://t.co/a6dYXjt7s0

[Train2Target @Train2Target]

We are happy to announce this paper from @Train2Target ESR @JessicaelRayes1 and her colleagues. Congratulations to all the authors! 🥳

'Disorder is a critical component of lipoprotein sorting in Gram-negative bacteria.'

https://t.co/qH8rPYiNRm

[Collet Lab @JFClab]

Happy to announce our last paper: how disorder controls lipoprotein targeting. Congrats @JessicaelRayes1 queen of the ultracentrifuge :) beautiful work, journey with @MichaelDeghelt @IorgaBI @bluegreen812 @NaemiC thanks @Welbio_asbl @UCLouvain_be @frsFNRS https://t.co/Pa5iTlcmpj

[Train2Target @Train2Target]

Happy to share this preprint on @biorxiv_micrbio:

'LptB2FG is an ABC transporter with Adenylate Kinase activity regulated by LptC/A recruitment.'

A collaboration between our ESRs @TiagoBaeta7, Elisabete Moura and their colleagues in Grenoble and Milan.

https://t.co/lsZVLn3WTI

[Collet Lab @JFClab]

Congratulations Raquel ! You have done a terrific work Dr Rodriguez Alonso ! We were all impressed by the high level discussion you had with the jury members. Good luck with your next step ! We will miss you. Thank you to @Train2Target

[Train2Target @Train2Target]

Meet our newest @Train2Target Doctor @RaquelRguezAl! Raquel publicly defended her PhD thesis on Friday.

Congratulations! 🥳🍾🎉

[Train2Target @Train2Target]

Congratulations to new the Dr. @MitjaMZ on successfully defending his PhD thesis last week 🥳🎉

Congratulations Mitja 🖖

[Train2Target @Train2Target]

Very happy to announce this new publication involving work by @Train2Target's Federico Corona and Prof. Waldemar Vollmer.

Combining Cell Envelope Stress Reporter Assays in a Screening Approach to Identify BAM Complex Inhibitors

https://t.co/lZnSiB3ter

[Train2Target @Train2Target]

Congratulations to @Train2Target and @AiCuris researcher @AranchaLopezPe1 for successfully defending her PhD thesis 'A target-based approach to identify scaffolds for developing novel PBP inhibitors' at Newcastle University!

💐👏💐👏💐👏💐

[Train2Target @Train2Target]

@MatthiasWinkle

[Train2Target @Train2Target]

That was it! We had a good time in Grenoble and are all going back to our homes-away-from-home!
Here's the group pictures :)

[Train2Target @Train2Target]

Very happy to announce this publication by @AranchaLopezPe1 and colleagues in @antibioticsmdpi

Discovery of Pyrrolidine-2,3-diones as Novel Inhibitors of P. aeruginosa PBP3.

https://t.co/JP8L8eouTn