Trialsgram

🫀 Daily study — one landmark trial, one card.
Design · N · endpoint · result · primary source.
Internal medicine, organised along the guidelines.

[Trialsgram @trialsgram]

ZENITH (2025) — In 172 patients with high-risk pulmonary arterial hypertension, sotatercept reduced death, lung transplantation or heart-failure hospitalisation compared with placebo.
https://t.co/Ntk2P7qW90 #EBM #MedTwitter

[Trialsgram @trialsgram]

CoCAP (2026) — In 360 patients after CABG for an acute coronary syndrome, dual antiplatelet therapy with ticagrelor was compared with aspirin alone on graft patency on CT angiography at 12–36 months.
https://t.co/ARR8ekDPFg #EBM #MedTwitter

[Trialsgram @trialsgram]

ESC Congress 2026: all 58 Hot Line trials in the register, each with its result and critique.
All 58 as one document: https://t.co/hhQ3p0kDDV
https://t.co/8vT2ZF87gI @escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

LAACS-2 — In 1,500 adults undergoing open-heart surgery, concomitant surgical left atrial appendage closure did not reduce stroke or TIA over 2 years compared with leaving the appendage open.
https://t.co/4F8a3WN8UC
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

PRAGUE-26 — In 558 patients with intermediate–high-risk pulmonary embolism, catheter-directed thrombolysis reduced death, recurrent embolism or decompensation at 7 days compared with anticoagulation alone.
https://t.co/5pYTFWigxe
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

HeartRunner — In 2,114 out-of-hospital cardiac arrests, smartphone activation of citizen responders did not improve survival at 30 days compared with standard EMS response.
https://t.co/ajulxP3hoZ
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

OHCA-CAG meta-analysis — In patients resuscitated from cardiac arrest without ST-elevation in randomised trials of angiography timing, early coronary angiography did not improve clinical outcomes compared with delayed…
https://t.co/iBbUoNX9wk
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

DISCO — In 1,003 comatose survivors of cardiac arrest without ST-elevation, immediate coronary angiography did not improve survival at 30 days compared with delayed, selective angiography.
https://t.co/g7sr0NxQMJ
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

CorCal — In 5,772 statin-naïve adults in primary prevention, coronary calcium score-guided statin therapy was not non-inferior to risk score-guided statin therapy for major adverse cardiovascular events.
https://t.co/XnXXrGoq5q
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

ISOLEDS — In 664 patients undergoing PCI of a distal left main bifurcation, OCT guidance was non-inferior to IVUS guidance for target lesion failure at 12 months.
https://t.co/e7SdlsoV3z
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

EVAOLD — In 587 patients aged 80 years or over with NSTEMI, a selective invasive strategy guided by stress imaging was not non-inferior to routine invasive management for death, myocardial infarction or stroke at 12…
https://t.co/FfI5y97KyL
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

Syncope-Stopper — In 200 older adults with high-risk unexplained syncope, upfront pacemaker implantation reduced cardiovascular death, recurrent syncope, bradycardia or device complications at 12 months compared with…
https://t.co/QAancPYavD
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

BPLTTC IPD meta-analysis — In 357,440 participants in 51 randomised blood-pressure trials, blood-pressure-lowering treatment reduced major cardiovascular events across the full spectrum of predicted risk compared with…
https://t.co/h766AgkOms
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

HIS Alternative II — In 148 patients with HFrEF and left bundle branch block, conduction-system pacing was non-inferior to biventricular pacing for the change in LV end-systolic volume at 6 months.
https://t.co/YuXOOFrU74
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

SyncAV PMT — In 1,288 CRT recipients with left bundle branch block, dynamic AV-delay optimisation did not reduce the reduction in LV end-systolic volume at 12 months compared with a fixed AV delay.
https://t.co/TLgRuCOpVi
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

DANISH-CRT — In 1,000 patients with heart failure and bundle branch block receiving CRT, electrically targeted LV lead placement did not reduce death or unplanned heart-failure hospitalisation compared with…
https://t.co/2Y7VUXtw1e
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

ASPIRED — In 2,233 emergency patients with unexplained syncope, immediate 14-day patch ECG monitoring did not reduce self-reported syncope episodes at 1 year compared with standard care.
https://t.co/tIpL2QQPJJ
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

ECLIPSE-CKD — In 640 adults with hypertension and stage G2–G3a chronic kidney disease, a potassium-enriched salt substitute reduced systolic blood pressure at 3 months compared with regular salt.
https://t.co/WJu3n1vj5i
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

CRHCP — In 33,995 rural Chinese adults with hypertension, village-doctor-led intensive blood-pressure control reduced all-cause dementia compared with usual care.
https://t.co/gfhnCrViij
@escardio #ESCCongress #ESC2026 #EBM

[Trialsgram @trialsgram]

SHASTA-3/4 — In 757 patients with severe hypertriglyceridaemia, plozasiran every 3 months reduced the change in fasting triglycerides at 12 months compared with placebo.
https://t.co/Ycc9oCVL6E
@escardio #ESCCongress #ESC2026 #EBM