J. Tushir-Singh, Ph.D.

Associate Professor @ucdavis
Protein Engineering, Cancer Immunotherapy
“The harder you work, the harder it is to surrender” Vince Lombardi
Scientist & Farmer

[UC Davis Health Medical Microbiology & Immunology @UCD_MMI]

Please join us on April 3 for our inaugural symposium entitled "Breaking Boundaries - From Discovery to Intervention: Charting the Journey from Basic Science to Biotech Breakthroughs"! Register now: https://t.co/m2va2GNqoT

[J. Tushir-Singh, Ph.D. @TushirSingh_Lab]

"If you keep your nose down in life and keep working, anything is possible." - Curt Cignetti

Unbelievable story of confidence, simplicity and success!

[ESPN @espn]

Hoosier College Football National Champion?

For the first time ever, IT'S INDIANA! 🏆

[J. Tushir-Singh, Ph.D. @TushirSingh_Lab]

@OvCaAcademy Thanks for posting

[J. Tushir-Singh, Ph.D. @TushirSingh_Lab]

A shot in the dark by our lab to potentially explain species-specific differences and the complexity of the TIGIT signaling pathway, and the colossal clinical failure of TIGIT antibodies.
This work was led by two UCDAVIS Undergrads, NOT by PhDs or Postdocs
https://t.co/NqdSZfR85x

[Medical Xpress @medical_xpress]

A gene therapy targeting X chromosome silencing has shown potential to reactivate healthy MECP2 genes in #RettSyndrome models, improving symptoms and offering hope for X-linked disorders. @NatureComms https://t.co/CrHVvjjbpr https://t.co/jnJAsqXK9a

[J. Tushir-Singh, Ph.D. @TushirSingh_Lab]

https://t.co/uriihGjbqK

[UCDavis News Service @UCDavisNews]

A single genetic mutation may have made humans more vulnerable to cancer than chimpanzees @UCDavisHealth https://t.co/8CpxU7s41h

[ilyas sahin, MD @ilyassahinMD]

Humans are more cancer-prone than primates despite over 98% genomic similarity. A FasL mutation unique to humans allows plasmin in solid tumors to weaken immune attack @NatureComms * .
Could blocking it boost immunotherapy?

[J. Tushir-Singh, Ph.D. @TushirSingh_Lab]

*NEW Paper ALERT*
Our new work in @NatureComms on FasL-mediated cancer cell death regulation has revealed that evolutionary substitutions (humans vs. primates) in the FasL extracellular domain render human FasL differentially susceptible to plasmin protease cleavage, a key metastatic protease involved in the metastasis of almost all solid tumors including ovarian cancer ascites, etc. Our findings explain the lower cancer incidence in primates (vs. humans) and also the deep mechanistic reasoning behind the potentially less successful outcome of T and CAR-T based immunotherapies against metastatic solid tumors (vs. leukemia, etc).

Congratulations to Wamba E, Mondal et al., and all other authors and collaborators @plegembre @carterra_bio (Dan Bedinger) @UCDavisMedCntr @UCD_Cancer @UCD_MMI

The manuscript can be found here:
https://t.co/wjOFgA1PdX

[J. Tushir-Singh, Ph.D. @TushirSingh_Lab]

@NDFootball It will be ND vs Texas championship game

[J. Tushir-Singh, Ph.D. @TushirSingh_Lab]

@historyinmemes Dogs are million fold more loyal than humans. Its true. I love my dog.

[J. Tushir-Singh, Ph.D. @TushirSingh_Lab]

@NBCOlympics This was amazing comeback…wow,!

[J. Tushir-Singh, Ph.D. @TushirSingh_Lab]

@AMAZlNGNATURE Make sense that more good things underwent positive selection in chimpanzee evolution than in human evolution :)

[L. Fernando Santana 🇵🇷 @lfsantana68]

Check out our new collaboration with @RoseEDixon1 from @ucd_physiology in @PNAS (https://t.co/Z5QrzOA668). We observed two modalities of beat-to-beat ATP fluctuations in ventricular myocytes based on SR-mitochondrial coupling strength. (1/2)

[Dmitriy Zamarin MD PhD @DmitriyZamarin]

Love ovarian cancer? Hate ovarian cancer? You’re not alone! Submit your abstracts to the Biennial Rivkin-AACR Ovarian Cancer Research symposium! This will be a fantastic meeting with the latest and greatest in ovarian cancer research. https://t.co/bwp66bp0qO

[J. Tushir-Singh, Ph.D. @TushirSingh_Lab]

Our Lab Group! Pic after @UCD_MMI Friday afternoon Research Forum, Great little presentation by Elvis for your lab.

[L. Fernando Santana 🇵🇷 @lfsantana68]

Professor Brian Kobilka delivering the keynote presentation during the 2024 Ed Krebs Symposium @UCDavisMed @UCDBMM

[J. Tushir-Singh, Ph.D. @TushirSingh_Lab]

@theNASciences @UMassChan Many Many Congratulations!!! Phil @zamore_lab Well deserved!

[J. Tushir-Singh, Ph.D. @TushirSingh_Lab]

@TsolisRenee @abaumler Congratulations!!! @abaumler Great looking couple pic!

[National Academy of Sciences @theNASciences]

Congratulations Phillip Zamore of @UMassChan, newly inducted #NASmember! #NAS161 #genetics #medicine