Tropical

Disruptive technologies in the works, great innovations full speed ahead.

[The All-In Podcast @theallinpod]

Friedberg: New study shows enzyme reverses skin age from 70+ years to 31

Chamath: That’s a $2T market.

Did Scientists Just Discover How to Reverse Skin Aging!?

“CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down.

So these scientists set out to try and create an enzyme, an enzyme is a protein that breaks something down, that can break down CML.

And so these guys kind of went out and they took the target, which is CML, and tried to figure out, ‘Okay, how do we actually degrade CML, clear that extracellular matrix, and reverse aging?’

They started to test it on the proteins that we would find in our body, casein, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degrade it away.

And then they found several sites where they were able to degrade over 90%.

And then they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31-year-old, this is from greater than 70-year-old patients, just by putting this enzyme on the skin.

And so it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.”

Chamath:

“It will be a trillion-dollar market. If you can create a cream…”

Friedberg:

“I mean, dude, if you could put this enzyme literally on your skin and have it absorb in…”

Chamath:

“Game over. That alone is $2 trillion.”

[Tropical @tvphat]

@PeacockTVCare - “The Killer” (2024) with Nathalie Emmanuel is not playing with the correct movie. Trailer is correct but not the movie itself.

[Daily Life Hacks @Impressivetips]

Firefighter shows technique that could save a life.

[jack @jack]

we're making @blocks smaller today. here's my note to the company.

####

today we're making one of the hardest decisions in the history of our company: we're reducing our organization by nearly half, from over 10,000 people to just under 6,000. that means over 4,000 of you are being asked to leave or entering into consultation. i'll be straight about what's happening, why, and what it means for everyone.

first off, if you're one of the people affected, you'll receive your salary for 20 weeks + 1 week per year of tenure, equity vested through the end of may, 6 months of health care, your corporate devices, and $5,000 to put toward whatever you need to help you in this transition (if you’re outside the U.S. you’ll receive similar support but exact details are going to vary based on local requirements). i want you to know that before anything else. everyone will be notified today, whether you're being asked to leave, entering consultation, or asked to stay.

we're not making this decision because we're in trouble. our business is strong. gross profit continues to grow, we continue to serve more and more customers, and profitability is improving. but something has changed. we're already seeing that the intelligence tools we’re creating and using, paired with smaller and flatter teams, are enabling a new way of working which fundamentally changes what it means to build and run a company. and that's accelerating rapidly.

i had two options: cut gradually over months or years as this shift plays out, or be honest about where we are and act on it now. i chose the latter. repeated rounds of cuts are destructive to morale, to focus, and to the trust that customers and shareholders place in our ability to lead. i'd rather take a hard, clear action now and build from a position we believe in than manage a slow reduction of people toward the same outcome. a smaller company also gives us the space to grow our business the right way, on our own terms, instead of constantly reacting to market pressures.

a decision at this scale carries risk. but so does standing still. we've done a full review to determine the roles and people we require to reliably grow the business from here, and we've pressure-tested those decisions from multiple angles. i accept that we may have gotten some of them wrong, and we've built in flexibility to account for that, and do the right thing for our customers.

we're not going to just disappear people from slack and email and pretend they were never here. communication channels will stay open through thursday evening (pacific) so everyone can say goodbye properly, and share whatever you wish. i'll also be hosting a live video session to thank everyone at 3:35pm pacific. i know doing it this way might feel awkward. i'd rather it feel awkward and human than efficient and cold.

to those of you leaving…i’m grateful for you, and i’m sorry to put you through this. you built what this company is today. that's a fact that i'll honor forever. this decision is not a reflection of what you contributed. you will be a great contributor to any organization going forward.

to those staying…i made this decision, and i'll own it. what i'm asking of you is to build with me. we're going to build this company with intelligence at the core of everything we do. how we work, how we create, how we serve our customers. our customers will feel this shift too, and we're going to help them navigate it: towards a future where they can build their own features directly, composed of our capabilities and served through our interfaces. that's what i'm focused on now. expect a note from me tomorrow.

jack

[Mindset Machine  @mindsetmachine]

The Moment You Realize Why Bruce Lee Is Timeless ❤️‍🩹

[Àgbà John Doe @jon_d_doe]

As a parent, I think this video has taught me something useful.

I recommend that you should try it on your kids, too.

I have also shared it with my wife.

Credit: joe_drummer_boy on IG.

[Tropical @tvphat]

@TheCleanCarClub 2

[Tropical @tvphat]

@otokyo 18

[Tropical @tvphat]

@RealVision Entrenching belief in Bitcoin, avoid short term noise, stay focus on long term and accumulate along the way.

[Real Vision @RealVision]

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@FitFusion__ 3452839

[Tropical @tvphat]

@GraceGym_ 34

[Tropical @tvphat]

@RenuKumari78 Python

[Massimo @Rainmaker1973]

MOTOROiD 2, Yamaha’s latest self-driving and self-balancing motorcycle.
https://t.co/uiw0RfEIUw

[Tropical @tvphat]

@RobinhoodApp Credit card with competitive cash back rates in crypto. Match Coinbase AmEx offering on Visa.

[Tropical @tvphat]

@NVIDIAGeForce GeForce Day

[Tropical @tvphat]

im skipping the line for Polymarket. if you care about being early, use my link: https://t.co/XNi4mwPXCT

[amit @amitisinvesting]

Tom Lee made his market open debut today on the show and we discussed a variety of topics including Ethereum & Bitmine:

- Why $ETH could be the biggest macro trade of the next decade

- How $BMNR is growing the NAV & ETH per share at an accelerated pace

- Ethereum end of year targets

Thank you to Tom @fundstrat for taking the time to join the show, we all deeply appreciated it!

[Tropical @tvphat]

@EmperorBTC Love your quick updates 🙏