Yusuke Iino

MD, PhD, researcher, interested in pathophysiology of neuropsychiatric deseases, University of Tsukuba, JAPAN

[Yusuke Iino @U8su8ke]

1/8
In our new preprint, we identify a clozapine-responsive prefrontal ensemble that stabilizes decision-making under NMDA receptor hypofunction.

We further show that this ensemble can be rationally reactivated by multi-receptor pharmacology.

https://t.co/2sJxt8JMa1

[Teruhiro Okuyama @Teru_Okuyama]

Our new paper is out in Science!

We reveal neural mechanisms for updating feelings, such as liking or disliking, toward familiar individuals.

Congratulations, Narutoshi and MuYun!🎉

https://t.co/hK0HsgpKbX

[Weston Fleming @westonfleming]

How does the brain link a novel food to illness that happens later? We found that acetylcholine, released in part by parabrachial Calca neurons, can work through GPCRs in central amygdala to bridge the gap.

New preprint from @gstuber + Palmiter labs: https://t.co/thcod1hJE8

[Takaki Komiyama @takaki_komiyama]

Our new paper is out in Nature, congrats to Sonja et al.! An excellent collab with Irina Dudanova's group.

We promoted neuroplasticity to improve behavior in a mouse model of a neurodegenerative disease.

https://t.co/9gkIs93VXs

[Yusuke Iino @U8su8ke]

@shi_shoi Thanks for your continuous support！

[Yusuke Iino @U8su8ke]

@k_hammer_1001 ありがとうございます！お時間あればぜひ！

[Yusuke Iino @U8su8ke]

1/8
プレプリントを公開しました。
クロザピン応答性の前頭前野アンサンブルが、NMDA受容体機能低下モデルにおける意思決定ノイズを抑制することを示しました。

さらに、このアンサンブルを多受容体薬理により合理的に再活性化できることを示しました。

https://t.co/2sJxt8JMa1

[Yusuke Iino @U8su8ke]

8/8
クロザピン応答性前頭前野アンサンブルは、意思決定を安定化し、多受容体薬理で合理的に再活性化できる可能性があります。
JNSでポスター発表します。
3P-289、8月1日 12:50–13:50

ぜひ議論させてください。

Preprint: https://t.co/2sJxt8JMa1

[Yusuke Iino @U8su8ke]

7/8 — Fig. 5
このカクテルはクロザピンの広い作用を単に再現するのでしょうか。
結果は違いました。

意思決定ノイズを改善する一方で、クロザピン様のNREM睡眠増加やデルタパワー増強は再現しませんでした。

[Yusuke Iino @U8su8ke]

8/8
Together, our results suggest that a clozapine-responsive prefrontal ensemble stabilizes decision-making and can be rationally reactivated by multi-receptor pharmacology.

JNS poster 3P-289, Aug 1, 12:50–13:50.

Preprint: https://t.co/2sJxt8JMa1

[Yusuke Iino @U8su8ke]

1/8
In our new preprint, we identify a clozapine-responsive prefrontal ensemble that stabilizes decision-making under NMDA receptor hypofunction.

We further show that this ensemble can be rationally reactivated by multi-receptor pharmacology.

https://t.co/2sJxt8JMa1

[Yusuke Iino @U8su8ke]

7/8
Does the cocktail simply mimic clozapine’s broad effects?

No. It rescued decision noise without reproducing clozapine-like NREM sleep or delta-power enhancement, suggesting partial separation of computational rescue from sleep-related effects.