Miles Mee

[Miles Mee @username_miles]

Happy to see our study "Longitudinal Study of Transcriptomic Changes Occurring over Six Weeks of CHOP Treatment in Canine Lymphoma Identifies Prognostic Subtypes" published in Veterinary Sciences! 🐕
https://t.co/52G5fjI7By
🧵
@uofg @OntVetCollege
#lymphoma #CoomberLab

[CitationNet @CitationNet_]

New Features to improve analysis of CitationNet result networks. 🧵
#science #literature #research

Highlight Topics.

[Miles Mee @username_miles]

You can highlight the connections of a specific publication (by clicking it in the results table).

You can filter the network results by - key word in publication title/abstract - to highlight those publications in the title and filter the results table.

[Miles Mee @username_miles]

I released CitationNet today! CitationNet makes it easy to browse and visualize citation networks over time!
https://t.co/H8f4AA3mIx

[CitationNet @CitationNet_]

CitationNet makes it easy to browse and visualize citation networks over time!
https://t.co/iFUYBpWKXj
#science #literature #research #citation

[CitationNet @CitationNet_]

Hello, world

[Arsenal @Arsenal]

Riding high 🏆

[GeneList @_genelist]

Use GeneList to search literature!
Add an addition to PubMed, Google and OpenAlex search links for each gene in your list!
eg. If you add 'Cancer' to 'Search Addition' panel, the PubMed link for MYC searches 'MYC Cancer' on PubMed.
https://t.co/mX0WrZUxQY
#bioinformatics #DNA

[Arsenal @Arsenal]

The Arsenal. Your Premier League champions.

[Toronto Blue Jays @BlueJays]

It was a magical ride with all of you.

Our city, our home, our fans showed up on the grand stage...and we couldn't be prouder.

[Arsenal Women @ArsenalWFC]

Taking it all in ❤️

[Miles Mee @username_miles]

7/7 In both comparisons there was up-regulation of pathways related to Inflammation, Transport, and Phosphorylation, and down-regulation of pathways related to DNA Damage Response and Cell Cycle implicating these pathways as being related to treatment resistance to CHOP. 🐾

[Miles Mee @username_miles]

Happy to see our study "Longitudinal Study of Transcriptomic Changes Occurring over Six Weeks of CHOP Treatment in Canine Lymphoma Identifies Prognostic Subtypes" published in Veterinary Sciences! 🐕
https://t.co/52G5fjI7By
🧵
@uofg @OntVetCollege
#lymphoma #CoomberLab

[Miles Mee @username_miles]

6/7 The figure bellow shows biologically important genes and pathways differentially regulated between the 6-week timepoint and pre-treatment timepoint for the cluster group with longer PFS. Notably multi-drug-resistance gene ABCB1 was up-regulated after 6-weeks of CHOP.

[Miles Mee @username_miles]

6/6 Adding co-treatment of Doxorubicin and proteasome inhibitors to CHOP may be beneficial in treating canine lymphoma. Further research of proteasome inhibitors is needed in other canine lymphoma cell lines, primary cells, in vivo models and canine pharmacokinetic studies. 🐾

[Miles Mee @username_miles]

Happy to see our study "Effect of proteasome inhibitors on canine lymphoma cell response to CHOP chemotherapy in vitro" published in Veterinary and Comparative Oncology!🐕
https://t.co/hyDMh53wSO
🧵
@uofg @OntVetCollege
#caninelymphoma #lymphoma #CoomberLab

[Miles Mee @username_miles]

5/6 We found synergistic effects when combining proteasome inhibitor Bortezomib and CHOP agents Doxorubicin and Vincristine. In both cases the combination was more effective at inhibiting cell growth of canine lymphoma cell line CLBL-1 cells.