Vadim Korotkov

[Vadim Korotkov @vadkorotkov]

@BaranLabReads @ChemRxiv @YuKawamata @JetTsien @Aron_Peter_ @ScienceAtBMS @Jiawei1024 @mx_million It's definitely a great work!!!

[Baran Lab @BaranLabReads]

Finally, RADICAL CROSS COUPLING without the exogenous REDOX. We disclose in @ChemRxiv (https://t.co/FYy6i1J7p9) a broadly general platform for achieving transformations that normally required excess metallic or chemical reducing agents or photochemical setups (and their requisite catalysts) or potentiostats for electrochemistry. Now, such transformations can be accomplished with the same ease that one conducts a Suzuki coupling. You can scale up (its homogeneous) or scale down (use cheap parallel screening plates). Moisture is tolerated and base metal catalysis is used. As the best engineers like to say, "The best part is no part". Now, chemists have the option to remove the redox part from radical couplings.

Quick Summary: Sulfonyl hydrazides are disclosed as versatile radical precursors as exemplified with seven new C–C bond forming, redox-neutral cross-couplings with: (1) activated olefins, (2) alkyl halides, (3) redox active esters, (4) aryl halides, (5) alkenyl halides, (6) alkynyl halides, and (7) a trifluoromethylating reagent to forge C(sp3)-C(sp3), C(sp3)-C(sp2), and C(sp3)-C(sp) bonds. Sulfonyl hydrazides are stable and usually crystalline substances that can be accessed in a variety of ways including transiently from hydrazones to achieve a net reductive arylation of carbonyl compounds. Exogenous redox (chemical, photo/electrochemical) additives are not necessary as these functional groups serve the dual role of radical precursor and electron donor. The operational simplicity (homogeneous, water tolerant, dump-and-stir) and practicality of the method are demonstrated as well as applications to streamlining synthesis and mild late-stage functionalization.

[Vadim Korotkov @vadkorotkov]

The Symphony No. 5 of Gustav #Mahler is a good start for the great Sunday

[Vadim Korotkov @vadkorotkov]

@Tsogoeva_Group @ChemRxiv @aztul @dfg_public Very interesting paper. Great!

[Vadim Korotkov @vadkorotkov]

Yesterday I was at the concert of @petshopboys in #Hannover. Great immortal music! Great show!!

[Vadim Korotkov @vadkorotkov]

Here is our new paper!
https://t.co/XABCKUDq8c

[Vadim Korotkov @vadkorotkov]

#braunschweig #spring #mascherode

[Vadim Korotkov @vadkorotkov]

@Tsogoeva_Group Happy Birthday!

[nature @Nature]

A new type of antibiotic targets a drug-resistant bacterium https://t.co/NQ5nzE5fwz

[Baran Lab @BaranLabReads]

Degrade proteins, not your work schedule! A new method appearing today @ChemRxiv (https://t.co/DtfoUJKEsc) simplifies access to molecular glues (like PROTACS) to save medicinal chemists valuable time. One-step access from cheap commercial materials, a trivial experimental setup, and superb chemoselectivity enabled by Ni-electrocatalysis. Another fun collaboration with BMS.

[Williamslab @Williamslab1]

Finally out! Our paper on nitrene reduction is now available - open access - at Org Lett @JOC_OL https://t.co/XvXC6Icu3B

[Vadim Korotkov @vadkorotkov]

Year 2023. I am at the @depechemode concert in Munich. Great!

[Vadim Korotkov @vadkorotkov]

@SieberLab @JosefBraun17 Congratulations!

[The Nobel Prize @NobelPrize]

Organic chemistry legend Robert Burns Woodward, awarded the 1965 chemistry prize, worked on organic synthesis. He successfully synthesised many substances such as cholesterol and chlorophyll, the substance that gives leaves their green color.

More info: https://t.co/15fQaaOiOV

[Baran Lab @BaranLabReads]

14 simplified natural product syntheses reported today in @ChemRxiv : https://t.co/fsK5Zx794f. These syntheses are enabled by a next generation doubly decarboxylative cross coupling (dDCC) that tolerates alpha-heteroatom substituents. In addition to the critical Ag-additive that turns on reactivity, the ligands play a key role in stereo controlled couplings.

Imagine a world where natural products like polypropionates can be made without recourse to aldol or epoxide chemistry but instead by just putting ubiquitous acid building blocks together like LEGOs.

Retrosynthetic analysis is often taught using the concept of "polar bond analysis" which has inadvertently led to an over-reliance on protecting groups, functional group manipulations, and redox-fluctuations. The advantages of radical retrosynthesis (https://t.co/fTSPpwrEJV), which is polarity agnostic, is on vivid display in this disclosure.

Thanks to our amazing collaborators at BMS (medchem and process), Pfizer, Biogen, and LEO Pharma.

[Baran Lab @BaranLabReads]

Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (https://t.co/UYahP1Hmv2). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed

[Buchwald Group @BuchwildGroup]

We designed a new class of anionic ligands that facilitate copper-catalyzed C–N cross coupling reactions at room temperature! Great work by @seoungtae_kim, @Strauss_MJ, and @alcamo92 (now at @LillyPad), now on @ChemRxiv – read more here: https://t.co/8yUvVwOALU

[Vadim Korotkov @vadkorotkov]

I received this present today. I am really happy that I can support homeless animals in the #Tierheim!!!

[Vadim Korotkov @vadkorotkov]

Salzburg is beautiful!

[Vadim Korotkov @vadkorotkov]

Endlich wieder in München