π€ I'm watching the "down with VO2max conversation" (π) unfold on X, and it has raised something interesting to me: how the distinction between "health" (mitigating risks/addressing dysfunction) and "fitness" (building/maintaining functional capacity to meet demands) is often lost.
FWIW, I really enjoy seeing actual scientists like you share their work (and relevant developments in the filed) here. Please continue to do so. π₯
(Next on my wish list is seeing it become more common to document research investigations via video. Starting to see a tiny bit of it here...)
While a 20% overall response rate, is not the kind of thing that makes a big splash in NEJM, there's reason to be very excited about this. The "impossible" label on TP53 has been ripped off.
This is just the first of what I think will be many p53-targeted compounds to come.
(from 2.19 workout)
π Cuz reps with the 45lb plate on pull-ups feels pretty metal ππ₯
Started recording my full daily workouts in January for "The 15-min Physique" project (2026 edition). More on that soon...
Let's see if I can get that last rep this week π
(Dec. 19th VO2 lab test)
π VO2max clocked in at 56 (> top 5% for my age) in the lab. This is up from 54 in august despite testing reduced exercise time over the past 12 weeks (15 min/day down from 20 min/day). π₯
π The 15 min/day pattern feels very, very sustainable and enjoyable. I don't feel interested in trying to reduce it further because I like having that minimal amount of movement in the day no matter what. π₯
π 15 min/day exercise pattern held up despite disruptive conditions. (See notes below.) π₯
π Test felt much more comfortable thanks to the 15-minute runs/time trials I've been doing...I was very sleep deprived during this test and was distracted by a disconcerting conversation just prior to the test, but still felt much more comfortable than last time. Usually poor sleep is punishing for hard runs... π₯
Full test video attached. Same machine. Same test operator. Same protocolβconstant speed with grade increasing every 3 minutes.
However, base speed was set to a 6:31 pace this time (down from 6:48).
The 15 minutes of exercise per day also includes strength training. I didn't really have any goals other than getting a little better at my 15-min run each week. I was also in a different environment about every 2 weeks due to travel. I also had a bike wreck that set things back. Execution was very imperfect (particularly sleep and diet), which was a good experiment to demonstrate the 15-min pattern could still hold up in non-ideal conditions...
Feeling interested in seeing what gains I can make by just dialing up the intention and execution....
Also interested in getting some beast mode shoulders and calves, getting kinda jacked again, and running a really good 5k time, just to demonstrate the method. Considering upping to 150-minutes per week just because "The 150-minute Physique" project (which comes out to ~21min/day) title pairs well with "The 15-minute Physique" project I did previously.
We'll see what 2026 has in store.
π first official Heart Power/vo2max lab test complete π₯
Full testing portion in the video (warmup not included). Protocol was the incline of the treadmill increased every 3 minutes. Speed stayed constant. (I think it was at 6:48 for me).
Clocked in at 54, which was a little lower than expected but not far since i was pretty sure wrist heart monitors miss heartbeats...
Ive got a ways to go to get to 60 in a lab test, but the good news is that i already feel the best ive ever felt both cognitively and cardiovascularly with just 20 minutes per day. (Ive definitely *looked* better in other chapters, but it just shows that u cant really see Heart Power.)
Also, i definitely recommend finding a health study to participate in. Ive enjoyed the 2 ive done and learned something interesting.
(Dec. 17th Run)
π What felt like a "tough run"/low performance day would've been a PR less than a month prior π₯
π Lucas reached his 2-mile goal π₯
π Lef soleus muscle held together, looking forward to getting it upgraded π₯
π Enjoyed the final run for the Brickell Route to close 2025 π₯
Lost a lot of ground on the final incline. But still outperformed expectations given the conditions.
π Set a new personal record on the Brickell Route: 2.48 miles in 15 minutes π₯
π Ran my all-time fastest 2-mile within it (11:58) and finally broke the 12-minute barrier π₯ π₯
π As I say in the video, the experience was "fucking transcendent." π₯ π₯ π₯
π Historically, I've rarely celebrated reaching a goal, because I just expected myself to reach my goals. This pattern comes with costs. I realized this a few years ago. But still don't think I've fully changed the pattern.... But after this run I definitely felt a moment of bliss and celebrated when I saw my watch (you would've heard me shout if you were within half a mile)βI felt a gain instead of an "avoided loss." That was also a victory.
π My method seems to be working. I've made this progress running less than 1 hour per week, and only *30 minutes per week* (plus some warm-up time) for the last 10 weeks, as part of my "2hrs per week method," which as far as I can tell is unheard of...
Last set of inclines on the route definitely got me a bit towards the end, but less than last time.
Pace chart has a pretty funny shape, basically looks like I was running .7 mile intervals π (The drop marks when I had to change direction, since the route is just back and forth on a .7 mile strip.)
I think this is partially because on the changes of direction my watch momentarily showed me as being below my target pace, so I would over-compensate.
A great run and a great experience π₯
(Dec. 8th run)
π Unlocked the Sand Francisco Fort Mason 15-min route: The Marina Green.
π First run with @max_maksutovic@TheNameIsBondss and others from the Founders Inc crew (need to add @atharvavaidya , @Prafulfillment , and @real_vaishak soon) π₯
π Got to see @max_maksutovic complete an impressive 1 mile PR at 8:59 within the 15 minutes π₯π₯
π Very clear now that biking is definitely a major lever for keeping my legs feeling good during these 15-min runs.
π Was surprised to see people wanted to do it again next week π₯ π₯ π₯
The cold was quite the adjustment. Really enjoyed the route design.
Would've been too perfect to have hit my 2.5 mile goal (felt like I could've done it despite having a lot of changes in direction on this route). But I get to continue the pursuit π₯
(Dec. 3rd run)
π debugged pacing issue: 9-13 minute mark when I can't see my watch very well but need to be pushing a lot harder to maintain pace.
Great run for the Brickell route.
π€ Watch might be selling me short. One of the guys that finished behind me went 2.41 and he thought I was at least .05 ahead. Also, when running the Coco Grove route with one of the guys, watch put my distance ~.04 shorter than theirs as well.
Pushing to get past the bridge next week, so I have a visual landmark π₯
(11.30 run)
π Unlocked the merits of more even pacing π
π Feeling the rhythm of a very good run coming up soon π₯
Laying off focusing on heart rate until I get a chest strap monitor. Based on last week's run, watch claims heart rate doesn't pick up for over 7 minutes no matter how hard I run. (For the record, i think the measurement has been more off than usual. Re-setting it may have helped.)
Focused on keeping a an even 6min/mile pace, which was a very different experience. Feels easy at that pace in the beginning...until it doesn't...
Dreaming of running the Brickell route with the team. π₯
(11.26 Brickell heartbeat run session)
π Thanksgiving eve run complete!
π₯΅ humid night that felt very hot once i got going, probably didn't help i came out even faster than usual. Time was "slow," but just a few weeks ago that would've been fast. Thus the pendulum swings and spirals up....
Lot of the team absent. And those that were present were hurting from holiday fun π
Will have to rally in december π₯