Pulmonary fibrosis is a deadly lung disease marked by excess scar tissue and WT1 upregulation, but the linking mechanism was unclear.
@vardhanediga@uofcincy now find WT1 reduces apoptotic clearance of fibroblasts and contributes to fibrotic remodeling in the lung: https://t.co/dJjYwnQ1kG
Video: RNA-ISH showing WT1 (red) and ACTA2 (green) expression in IPF lung tissues in 3D
JCI - Wilms tumor 1 impairs apoptotic clearance of fibroblasts in distal fibrotic lung lesions https://t.co/wF27BfqbiV
“I am pleased to share that my recent work has been published in The Journal of Clinical Investigation. The final version of the article is now available.