Varvara Paraskevopoulou

Instructor @NYUGSOM_Path • Molecular Biologist • Interested in Leukemia, Tumor Microenvironment & Cancer Biology

[Varvara Paraskevopoulou @VarvaraParask]

Respiratory failure is a leading cause of death in AML.
It begins when leukemia infiltrates the lung. Almost nothing was known about what happens locally.
We looked.
🧵 @NatImmunol
🔗 https://t.co/OkhyRTRN4F

[Varvara Paraskevopoulou @VarvaraParask]

@soobeomlee @NatImmunol Thank you Soobeom!!

[Varvara Paraskevopoulou @VarvaraParask]

Respiratory failure is a leading cause of death in AML.
It begins when leukemia infiltrates the lung. Almost nothing was known about what happens locally.
We looked.
🧵 @NatImmunol
🔗 https://t.co/OkhyRTRN4F

[Varvara Paraskevopoulou @VarvaraParask]

@abanos @NatImmunol Thanks Aggelos!

[Varvara Paraskevopoulou @VarvaraParask]

@stelioskosmidis @NatImmunol Thanks so much Stelio!

[Varvara Paraskevopoulou @VarvaraParask]

@MathijsSanders @NatImmunol Thank you Mathijs!!

[Varvara Paraskevopoulou @VarvaraParask]

@etrompouki @NatImmunol Thank you Eirini!!!

[Varvara Paraskevopoulou @VarvaraParask]

@efapostolou29 @NatImmunol Thank you so much Effie!!

[Varvara Paraskevopoulou @VarvaraParask]

@ManelEsteller @ZiyanLin2352 @iannisaifantis1 Thank you so much Manel!

[Varvara Paraskevopoulou @VarvaraParask]

Key points:
• AML reshapes the lung into an inflammatory, damaged niche
• Galectin-9 and IL-33 signaling : key players within the AML lung TME
• Targeting these pathways reduces lung infiltration and systemic disease burden
• Glucocorticoids improve pulmonary function

[Iannis Aifantis @iannisaifantis1]

Excited to share our study on immune interactions in extramedullary (lung) acute myeloid leukemia (AML) out today at @NatImmunol !! Acute respiratory failure frequently occurs in AML due to leukemia infiltration of the lungs. The question is why and what can we do to suppress it. @VarvaraParask in the lab started this work by mapping AML:stromal and AML:immune cell interactions using scRNA-Seq and Visium/Xenium @10xGenomics spatial tools.
https://t.co/96RB7muFZK

[Manel Esteller @ManelEsteller]

🚨 Excited to share our new Nature Immunology @NatImmunol paper! 🫁
How does acute myeloid #leukemia hijack the #lung and trigger #respiratory failure?
We found #AML cells drive #pulmonary remodeling via Galectin-9 & IL-33 signaling. And we identified drug treatments that can reverse it! 💊
Huge thanks to an amazing teamwork co-led with @iannisaifantis1 @VarvaraParask @nyugrossman
https://t.co/otxrK7d0Cq

[Varvara Paraskevopoulou @VarvaraParask]

Also many thanks to @AkEisfeld @sanamloghavi @ThalesPapaG @artsinyc and everyone else who contributed @NYUGSOM_Path @nyugrossman !
#AifantisLab #Leukemia #TME

[Varvara Paraskevopoulou @VarvaraParask]

This study is the main focus of my postdoctoral work in the Aifantis lab.
Huge thanks to all co-authors and collaborators, especially @ZiyanLin2352 for the beautiful computational analyses, my mentor @iannisaifantis1 for his support, and @ManelEsteller & his team!

[Sanam Loghavi, MD صنم لغوی 🔬🧬 @sanamloghavi]

Thank you @_TanyaBondar_ for highlighting our paper. We are thrilled to see the work out today in Blood Cancer Discovery. For all our friends in the myeloid community, @BCD_AACR has made the full text available for free until Friday! Please download it today https://t.co/AeH3QQdfqN
A huge thanks to @AkEisfeld @iannisaifantis1 @audrey_lasry @BettinaNadorp … working with you on this project was a pleasure and a privilege 🙏🏻💜
PS: it is not everyday that you get interviewed by BCD’s Abigail Cleveland in front of not one but 2 #HassanHajjaj pieces in the background … EPIC!!!
Stay tuned for the interview!!!

[Audrey Lasry @audrey_lasry]

Very excited to share our work on myeloid sarcoma, out today! Don’t miss @iannisaifantis1 presenting it this afternoon at #Myeloid2026

[Iannis Aifantis @iannisaifantis1]

Annual #AifantisLab photo...#2026. Amazing to work with great colleagues...in a great city and institution @nyugrossman ...visit our online sites to learn more on our work in leukemia, epigenetics and tumor microenvironment: https://t.co/ciUzeZ9OLn ; https://t.co/FG9WwqVucq

[Varvara Paraskevopoulou @VarvaraParask]

@iannisaifantis1 @nyugrossman Congratulations Iannis! Excited for the next chapter!

[Eric Wang @ewang2323]

Excited to share our lab’s second paper published in @ScienceTM led by @spicyscientist and @Cuijuan3! 1/

https://t.co/PiLTbc1TQS

[Aikaterini Polyzou @KaterinaPolizou]

https://t.co/84SFSPkp6B Our work is out!!!🎉🎉🎉

[Iannis Aifantis @iannisaifantis1]

Welcome on X Dimitri Papaioannou (@DimitriosP60249) a physician-scientist affiliated with our lab @nyugrossman !!! And would like to share his latest paper on a protein-coding circular RNA controlling DNA damage in myeloid leukemia...!
https://t.co/Wk5E80bULf