VDG Lab @ EPFL

News from the Laboratory of Cell and Membrane Biology (Gisou van der Goot Lab) at EPFL in Lausanne, Switzerland.

[VDG Lab @ EPFL @VDGLab]

Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence
https://t.co/1vGgyz6uiW

[VDG Lab @ EPFL @VDGLab]

A fantastic collaborative effort! Congrats to all involved! @FS_Mesquita @AbramiLaurence @MaurineLinder10 @ShernazBamji @chembioBryan and Gisou van der Goot!
@NatRevMCB

[VDG Lab @ EPFL @VDGLab]

Late publicity! Check our last review regarding the wonderful world of S-#acylation aka #Palmitoylation. A comprehensive overview of the field and our take on the interplay between this #lipid #PTM and #immunity #metabolism #cancer and #brain. https://t.co/JoJuaUG0WC

[Nature Reviews Molecular Cell Biology @NatRevMCB]

Now Online Mechanisms and functions of protein S-acylation https://t.co/TUo4vcERXw

[The FEBS Journal @FEBSJournal]

💡Viewpoint💡
💫S-acylation: an orchestrator of the life cycle & function of membrane proteins💫
✍️By @FS_Mesquita, F. Gisou van der Goot et al from @EPFL_en
➡️https://t.co/ERXytc2zw6
#deacylation #ERassociateddegradation #palmitoylation #proteinturnover #Sacylation #OpenAccess

[VDG Lab @ EPFL @VDGLab]

Big thanks to all our collaborators and everyone from the @VDGLab @Trono_Lab @ACCESS_Unige. Learn more about the details of how cell damage caused by #viruses #toxins or #colitis regulates protein #acylation #palmitoylation, check it out!

[VDG Lab @ EPFL @VDGLab]

Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence
https://t.co/1vGgyz6uiW

[M. Umair Anwar @MUmairanwar1]

Delighted to share our take on the only reversible lipid PTM--S-acylation as a major regulator of protein dynamics and function and its implications in health and disease in @JCellBiol . @gvdgoot Thanks so much. Proud! Highlights in thread (1/7)
https://t.co/RaYNZGKKU8

[Journal of Cell Biology @JCellBiol]

Review: S-acylation is one of the most frequent posttranslational modifications that regulates diverse cellular processes. @MUmairanwar1 and @gvdgoot @EPFL_en discuss the complexity and disease implications of this highly regulated reversible lipidation. https://t.co/u6pE2vQbpB

[VDG Lab @ EPFL @VDGLab]

Finally, we show that #viruses produced by Long-ZDHHC20-expressing cells have enhanced infectivity. More details in the manuscript!

[VDG Lab @ EPFL @VDGLab]

#SARS2 #Lipidation Chapter2. How #SARSCoV2 boosts Host #Palmitoylation to promote infectivity! #Infection shifts transcription of ZDHHC20 palmitoyltransferase to increase #Spike Palmitoylation and produce more infectious #virus Stay tuned for Chapter3
https://t.co/81eX8duDjp

[VDG Lab @ EPFL @VDGLab]

The N-terminal extension of ZDHHC20 prevents the protein from leaving the ER, extends its half-life, and enhances its #Spike modifying capacity by more than 35 times!

[Giovanni D'Angelo @Gio_Dangel0]

Is there more than transcriptional programs to drive cell identity? Here with @GioeleLaManno we discuss the lipotype hypothesis https://t.co/loAXj0Kx5Z

[Cell Biology J-Club @cell_club]

ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains https://t.co/Mt7OQGBzR1

[Giovanni D'Angelo @Gio_Dangel0]

This was really a nice journey … thank you @MUmairanwar1 , @oxyquips and @AbramiLaurence for taking us this far…

[M. Umair Anwar @MUmairanwar1]

Thanks to all involved, in particular @oxyquips @AbramiLaurence @gvdgoot @Gio_Dangel0.
@VDGLab we have to celebrate. 2/2

[M. Umair Anwar @MUmairanwar1]

How are membrane nanodomains formed? Delighted to share our preprint where we show that plasma membrane compartmentalization is controlled by rapid lipid composition remodeling at the ER-Golgi contact sites. (1/4)
https://t.co/Lm7pJLnDmX

[VDG Lab @ EPFL @VDGLab]

Great team effort that characterizes the #viral #lipid composition and shows that host #lipidation is required for #SARS-CoV2 infectivity!
@Gio_Dangel0 @matteodp @labriataphd @Trono_Lab
@EnyaQing @FS_Mesquita @AbramiLaurence

[VDG Lab @ EPFL @VDGLab]

Our work is out! We are happy to share how #Palmitoylation controls #SARSCoV2 (#Covid19) #membrane #Cholesterol organization, and promotes #infection
https://t.co/qAUZI2ddx4