@davidcaceres_mx@LatinXChem@OrgBiomolChem@EurJOC@beyondbenign@green_rsc@RSC_Sus Hello david, to synthesize these compounds and some others, acetonitrile was used as a solvent, which is better than a protic solvent for SN2 reactions, in addition to the fact that some of my alkyl halides are more volatile than those used in those compounds.