Some recent evidence has suggested that the non-structural proteins of COVID-19 can attack hemoglobin and displace the iron. Perhaps a mechanism for decreased gas exchange and decreased O2 in patients?
@cameronks There is some evidence that the virus nonstructural proteins can attack the Beta chain of hemoglobin and displace the iron disrupting gas exchange. Could this observation in part account for "altitude sickness" phenotype? another report suggested improvement with EPO. thoughts?
We reanalysed the @ELVISSTUDY (Hypertonic saline nasal irrigation & gargling) data for Coronaviruses. 2.6 day reduction in duration of symptoms (p=0.054) in the 15 individuals infected with coronaviruses. Gave us a few reasons to plan a study on #COVID19. https://t.co/KeGcGCuepJ
Yes #COVID19 is sweeping the world, and our @BCM_TropMed@TexasChildrens is pursuing a new #vaccine. But we're also maintaining our commitment to all the major #NTDs. Here's a new paper just out with me, @mebottazzi@a5hi5h on Central Latin America https://t.co/iKhguNbPKt
*Preliminary* #COVID19 study in @JAMA_current
- 5 critically ill pts. on mechanical ventilation
- All treated w/ convalescent plasma w/ #SARSCoV2 antibody
- In 4/5, SOFA score⬇, viral loads⬇, ARDS resolved
- All 5 stabilized, 3 at home
* Need an RCT
https://t.co/bBoI74f7jD
I have gotten several queries from patients and providers with elevated Lp(a) and risk of COVID-19 if infected, particularly with cytokine storm potentially increasing Lp(a) and CV events. I have drafted a generic letter and making it public if it will help anyone stay safer.
It would be helpful to begin seeing #COVID19 cases by zip code, but I'm guessing in places like #NOLA, #Detroit, #SARSCoV2 is emerging as a health disparity
#COVID19 case fatality rate in #Louisiana#NOLA is 4%, highest in #USA, several times higher than most other places. Reasons require study, but I believe due to 1) overwhelmed health systems + 2) extreme #GulfCoast poverty linked to diabetes, HTN, NCDs https://t.co/NxFeK1VzyV
@VigerustPHD@FDRLST I would expect that you would want your message taken seriously, as it should be. That’s not possible when any aspect of the published piece contains “Wuhan flu” or “Wuhan coronavirus,” regardless of whether you put it in or not. That’s a serious probes & disrespect to you.