Anyone else having issues with tiny holes in the bottom of @VWR tubes? This happened to me twice this week, luckily not with anything precious or radioactive (although having it happen with phenol:CHCl3 is not great!)!
We are thrilled to announce that we finally have the approval for our Phase 1b study to test OMO-103 in metastatic PDAC patients in combination with standard of care in first line! This is another milestone for @peptomyc and its fantastic team. Stay tuned.
Rufian: "ERC ha tornat a guanyar dintre el bloc independentista".
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Acaba de perdre 417.000 vots.
Quin desastre. Quina vergonya.
Cal passar-los per sobre.
Disadvantages for non-native English speakers in scientific research.
*propose a ‘concerted effort, at institutional level, to minimise the disadvantages for non-native English speakers’
* survivorship bias explains disappearing disadvantages
https://t.co/LcWCvt2A0z
Our chemogenetic tool SPARK-ON decouples phase separation from protein levels, drives condensate formation including transcription factors and cytosolic proteins e.g. G3BP1, enables dissection of the biological role of phase separation. Thanks @ACSCentSci. https://t.co/RuifspukJc
TransitID is out today in Cell! This is a proximity labeling method for unbiased discovery of endogenous proteins that traffick from a defined “source” location to a defined “destination” location. TransitID uses sequential labeling by TurboID in the source, followed by a chase period (minutes to hours) and then 1-minute APEX tagging in the destination compartment. Proteins tagged by both enzymes are enriched with streptavidin and anti-fluorescein antibody, and identified by mass spec.
We explore 4 intracellular and intercellular applications of TransitID:
- discovery of locally translated mitochondrial proteins (translated at OMM, then imported into mito matrix)
- mapping proteins whose cytoplasm-to-nucleus shuttling is dampened by stress
- discovery of proteins that transit between nucleolus & stress granules during stress & stress recovery
- analysis of proteins that traffic intercellularly bw tumor cells & macrophages
Work of amazingly talented co-first authors @WeiQinChemBio and @CheahJoleen, and collaborators Steve Carr @namude & Paul Taylor
https://t.co/yo4laOA14z
👏 We are excited to introduce you to our new John Goldman Fellow for 2022 @Richardson_S_E, from @Cambridge_Uni.
Find out more: https://t.co/XCc0lEWMxP
🧵...
As my hols end and I fly back to the U.K. after spending nearly a whole day and costs getting tests and filling in multiple forms despite my COVID vax passport I do think this is a waste of time and money. Only 1 in 20 day two tests on return are being studied for variants now ..
The coronavirus has had a devastating impact on our finances. As a result, today we presented a proposal to our staff that would mean us becoming smaller. It’s a sad day for everyone connected with our charity. 💔
Read our statement 👇
https://t.co/kTAYSiLNaT
As promised, here is the updated figure with data from yesterday. You can see how the UK epidemic is closely following Italy's, with a 14-15 day lag and the same doubling rate. We need a national lockdown by Monday just to be as badly hit as Italy. Time is running out.#UKlockdown
Incredible read, Science paper from the year 1919 about the Spanish flu pandemic:
There is one and only one way to absolutely prevent it and that is by establishing absolute isolation.