We integrates genetically predicted transcriptomic signatures, drug perturbation screening, longitudinal EHR and human cortical organoids to build a scalable framework for Alzheimer’s drug repurposing. Aspirin emerged as a reproducible signal.
https://t.co/pp17VgtfO3
Our new study shows that grounding LLMs in clinical guidelines can substantially improve extraction of genome-informed recommendations from EHR notes. A promising step toward scalable, real-world evaluation of precision medicine implementation. https://t.co/BZaNOC1kMo
Nature Digital Medicine has announced a special collection, "Evaluating the Real-World Clinical Performance of AI". I will be serving as a guest editor and would like to invite you to consider submitting your work. The Collection page is https://t.co/aZX50tWTJ9
Let’s rethink how we harness the semi-structured, high-value data buried in EHRs.
Leveraging Natural Language Processing for Echocardiographic Data Extr... https://t.co/6DxhsM8X5Y
A @VUMChealth research team, including @weiweiqi and QiPing Feng, PhD, will perform a search for any drugs approved for other diseases that could warrant laboratory study, preparatory to clinical testing, for treating #Alzheimers & related #dementia.
https://t.co/lYEotaCvXv
Exploring beyond diagnoses in electronic health records to improve discovery: a review of the phenome-wide association study https://t.co/7v8w2wUREf @monikagrab_ , @EKerchberger, @nicholas_wan
Absolutely thrilled to be working on this project, and congratulations to the team!
$3.4 million research grant targets risk of heart attack, stroke https://t.co/T06qCb7KfL @vumcdbmi, @VUMCgenetics, @vandy_biostat , and @VUMC_heart
Our study in the Journal of Lipid Research shows individuals with AA who have hypertriglyceridemia exhibit a higher prevalence of genetic risk factors compared to those with normal triglyceride levels,https://t.co/PqKtPrU2Ni
It's my pleasure to have been selected as 2024 Chancellor Faculty Fellows. My lab remains committed to contributing to phenotyping and advancing precision medicine. Thank you, @embimd,@trentrosenbloom, @bradmalin, @vumcdbmi, and all my other friends! https://t.co/krOKZNPvCl
@BoulierKristin @vumcdbmi Great questions. The LDL changes vs. doses indicate patient adherence; a higher dose generally results in a greater reduction in our dataset. PCSK9 patients were a small group; they were not included in the analysis.
Our latest publication in JACC ADV highlights the correlation between an individual's ED50 and Emax of statin and ASCVD events. As reviewers noted, this research supports the trend toward personalized medicine. https://t.co/jRajMoLkvu
@vumcdbmi