William Breen

Radiation Oncologist @MayoClinic

[NRG Oncology @NRGonc]

NRG-BN014, A Phase III Randomized Clinical Trial of Proton Craniospinal Irradiation versus Involved-Field Radiotherapy for Patients with Breast Cancer or Non-Small Cell Lung Cancer Leptomeningeal Metastasis (RADIATE-LM) is open to patient entry. @theCTSU @nyulangone

[William Breen @wgbreen]

@MayElbannaMDPhD @aadel_chaudhuri @MayoRadOnc @WUSTL @pradeep198212 @DanielMaMD Hard earned expertise through lots of chicken shawarma with @EricLehrer @KrishanJethwa @DavidRoutmanMD @TheColonelGray

[William Breen @wgbreen]

@MayoRadOnc @MayoFellows This means a great deal coming from such an awesome group of residents, thank you very much

[U-M Rogel Cancer Center @UMRogelCancer]

Congratulations to @MichelleMKimMD who received an R50 grant from @theNCI to support multidisciplinary coordination of care and research for central nervous system tumors: https://t.co/nItalEeZ57

[William Breen @wgbreen]

Also credit to @RomanKowalchuk @deanna_pafundi @DanTrifMD Sujay Vora and others working on the next steps.

[William Breen @wgbreen]

Thanks to @n_laack for the mentorship and vision to bring this program about, and many collaborators trying to improve outcomes for these patients including Paul Brown, Jann Sarkaria, @AnitaMahajanMD @DavidRoutmanMD @MichelleMKimMD Deb Brinkmann, Jing Qian, and others.

[Nadia Laack, MD MS @n_laack]

Fortunate to have @wgbreen leading our program for advanced imaging in CNS radiation treatment - a tireless advocate improving patient outcomes for this terrible disease @MayoCancerCare @MayoRadOnc

[Pamela Samson, MD @samsonpp]

So great to have @SBRT_CR at #ASTRO22 to discuss the latest research in noninvasive cardiac radioablation and how the field continues to move forward!

[Mayo Clinic Radiation Oncology @MayoRadOnc]

What a packed day! Started off with our team winning 🥇@RO_Institute 5k with @HunterGits winning 🥈, great talks by residents @Dr_Burlile, @RobertGaoMD & prospective med student Ben Talom, and a round of 👏🏼 to @wgbreen for his late-breaking CNS work. #ASTRO22

[Daniel Ma @DanielMaMD]

Fantastic presentation by @wgbreen of @MayoCancerCare / @MayoRadOnc on behalf of @ALLIANCE_org demonstrating the critical role central review in the results of N107C/CEC.3.

[William Breen @wgbreen]

@jana_ivanidze @JNeurooncol @n_laack @DavidRoutmanMD @MRuff100 @AnitaMahajanMD @ASTRO_org @MayoCancerCare @MayoRadOnc Thanks! Quite variable from patient to patient. Sometimes in FLAIR (often where the entire FLAIR wouldn’t be safely treatable), sometimes outside of any FLAIR or DWI+.

[William Breen @wgbreen]

@Emily_R_Song @JNeurooncol @n_laack @DavidRoutmanMD @MRuff100 @AnitaMahajanMD @ASTRO_org @MayoCancerCare @MayoRadOnc Appreciate the comments, and agree that recurrent GBM is a real challenge to treat, as these patients don’t have proven options. Are we sure adding PET guidance couldn’t improve outcomes? It might be feasible that more accurately targeting tumor leads to better results from RT?

[William Breen @wgbreen]

@jryckman3 @DrChowdharyMD @Mat_Guc @drdavidpalma @aadel_chaudhuri Great points @jryckman3. Always hesitant to use conventional fractionation after CHISEL, but agree HILUS gives pause. Consistent takeaway from this data and ours: need to be very careful about PBT max (and accordingly tx planning and IGRT). Best dose is still unknown.