Widodo Hadisaputro

Akademisi @UGM;
A biotechnologist by training
UGM - UNSW - Uni Melbourne

[King Purwa @BosPurwa]

Owh salah satu komisarisnya dari PBNU, hmm..

[GenBio AI @genbioai]

1/ We’ve updated AIDO.ModelGenerator, our open-source framework, which enables scientists and engineers to integrate their own data with all publicly available data using state-of-the-art (SOTA) foundation models. AIDO.ModelGenerator can be used for adapting, benchmarking, and applying biological foundation models across many modalities and scales. 🧬🦠

New foundation models, datasets, and tutorials are now available on @HuggingFace and @GitHub.

[Widodo Hadisaputro @widodohadisaput]

@CPFC Congrats...👏👏👏

[Widodo Hadisaputro @widodohadisaput]

@Lamineeyamal__ Great job Lamine...👏👏👏

[Widodo Hadisaputro @widodohadisaput]

@geraardmartin Great performance Gerard...👏👏👏

[Widodo Hadisaputro @widodohadisaput]

@Cubarsiiii Good job bro...👏👏👏

[Marcos Arrut @MarcosArrut]

Does mitochondrial dysfunction cause aging? No. And here's why.

One of the most widespread theories of aging holds that mitochondria—the cell’s power plants—deteriorate over time, and that this deterioration is the fundamental cause of aging. The basis of this hypothesis is that, while producing energy, mitochondria also generate reactive oxygen species (ROS), molecules that can damage DNA. From this perspective, the gradual accumulation of such damage would lead to organismal aging.

However, when we examine this theory more closely, inconsistencies emerge that seriously challenge its validity. One of them appears at a critical moment in human development: conception.

During fertilization, when the sperm fuses with the oocyte to form the zygote, the mitochondria inherited by the new organism come exclusively from the oocyte. In other words, the mitochondria of the zygote—and thus of every human being—are entirely maternal in origin.

Now, if aging were caused by the accumulation of mitochondrial damage, we would expect babies to be born already aged. Why? Because, by the time of conception, the mother already exhibits mitochondrial damage in their cells—including their oocytes. Therefore, if aging resulted from deteriorated mitochondria, a child would inherit aged mitochondria and be born biologically old.

But that’s not what happens. Babies, even those born to older mothers, possess fully functional mitochondria, healthy metabolism, and an age of zero. This observable and verifiable fact directly contradicts the notion that aging stems from accumulated mitochondrial damage.

Nonetheless, this theory has contributed to the rise of antioxidant-based interventions, aiming to counteract the oxidative stress associated with aging. Yet after decades of research, experimental evidence has failed to show that antioxidants produce significant increases in lifespan, whether in humans or in animal models.

Some antioxidant compounds, such as astaxanthin, have shown positive effects in various studies, but not because they neutralize reactive oxygen species. Their efficacy lies in their ability to modulate key regulatory pathways involved in longevity—such as FOXO3, SIRT1, and Klotho—and to enhance autophagy through the regulation of AMPK, PI3K/Akt, and MAPK (JNK and p38). In other words, their benefits stem from functional gene modulation, not from their antioxidant activity.

Still, the antioxidant market continues to grow. In 2024, it was valued at $4.84 billion, and it's projected to reach $7.64 billion by 2032. The only thing that doesn’t seem to age is the business behind it.

So what’s the point of all this? That aging is not an inevitable consequence of cumulative damage, but a biologically regulated process. Each cell carries the instructions to remain young—but over time, those instructions are progressively silenced. Mounting evidence points to an epigenetic origin of aging: a program, deeply embedded in the genome, that gradually shifts gene expression, disrupts cellular function, and leads to tissue decline.

Understanding this is not just a scientific milestone—it’s a call to action. Because if aging is programmed, then it can be reprogrammed. And that is exactly what we intend to do.

That's all.

[The Gecko Project (BlueSky: @thegeckoproject.org) @geckoproj]

🚨BREAKING: Konglomerat Harita Nickel di Maluku Utara yang memasok pabrik baterai mobil listrik–pemasok raksasa mobil Tesla, Toyota, dan BMW–telah mencemari mata air warga dengan racun kromium-6, ungkap bocoran dokumen internal.

👇Baca seluruh temuan https://t.co/E3A98hE3f1

[Andrew Panella @Longevity_EDU]

Insulin resistance.

The hidden cause of obesity, heart disease and cancer.

10 supplemements to reverse insulin resistance (bookmark this):

1. Ceylon Cinnamon

[The Jakarta Post @jakpost]

Enough with police brutality: Activists - Politics - The Jakarta Post #jakpost https://t.co/1fER2ARHLb

[malikaa bahng @chrisswifes]

UP LAGI TEMBUSIN SATU JUTA POST!!!!!!! JANGAN KASI TURUN!!!🔥

#GagalkanRUUTNI
#CabutRUUTNI
#PeringatanDarurat
#IndonesiaGelap
#TolakRUUTNI
#TolakRevisiUUTNI
#PeringatanDarurat
#IndonesiaGelap
#TolakDwifungsiABRI
#SupremasiSipil

[Tribun Jogja @tribunjogja]

Tribun Jogja edisi Sabtu, 22 Maret 2025.
#kamitidaktakut
#tempo
#demokrasi

[Never @neVerAl0nely___]

Alerta... Alerta...‼️ Jakarta Hari Ini..‼️

Bantu share gaess.... Aparat melakukan aksi kekerasan terhadap peserta aksi

Gedung DPR MPR RI Kamis malam 20.03.25

[CLEAR Center @UCDavisCLEAR]

Feeding seaweed to cattle shown to ⬇️ methane emissions by ~40% according to researchers at @ucdavis. Offers an effective way to ⬇️ emissions, particularly for beef cattle which spend 3 months on feedlot & majority on pasture — grazing & producing CH4. 🌱

https://t.co/q5FMAXow5A

[YLBHI-LBH Semarang @lbhsemarang]

*SIARAN PERS*

*PELAJAR SMK N 4 SEMARANG DITEMBAK HINGGA TEWAS; USUT TUNTAS DAN SEGERA REFORMASI KEPOLISIAN*

Selengkapnya di:
https://t.co/buKWd0nezB

[Jens Walter @JensWalter15]

What is a healthy #microbiome, and is there such a thing? Perspective published in @NatureRevMicro by a large team of international experts, colleagues from @Pharmabiotic, and the EU funded Human Microbiome Action Consortium.

https://t.co/f5An12xvLb
https://t.co/Y3RBgbB1xh

[Troll Football @TrollFootball]

Why Vinicius didn't win the Ballon d'Or

[nature @Nature]

Scientists have engineered a modified insulin that reduces its activity at low glucose levels https://t.co/WWU6sXBTbs

[Samuel Hume @DrSamuelBHume]

Biggest medical discoveries of the week (🧵)

1/8

An engineered insulin, NNC2215, whose activity is adjusted by glucose concentration

Its affinity for the insulin receptor drops >3-fold when glucose levels fall - reducing the risk of hypoglycaemia

https://t.co/TJAx8vGN6R

[CLEAR Center @UCDavisCLEAR]

Our short-video explainer highlights how nature captures carbon through various carbon sequestration techniques. 👇

https://t.co/zKk9xVtfYu