@JAMA_current A misnomer. In severe obesity hyperphosphorylation of toponin directly impairs contractility in proportion to obesity (Science 2026) - weight loss is the mainstay, GLP-1 helps. #StopHFpEFmimics as #HFpEF when only a minority ~10% have true elevated filling pressure (Bellicini 26)
@fervenzaf@arvindcanchi@NEJM@isn_india@ISNeducation@ECNeph Thanks for the rationale. So, if we compare this with ongoing wars in 2026,
RTX is like Israel with the support of US, attacking a country
OBI is like Russia attacking another country
But Majesty like US attacking Venezuela & declaring victory in a short period
Simply put.
@MorningNorth
Midnight calls and false alarms: Why rural patients deserve better laboratory services.
This might be of interest to Northern Ontario population
@Dilushiwijay@arvindcanchi Depends on what % . 5% is no different than colloids. 25% 100cc 2-3 times a day for few days almost always works, helps with diuresis with lasix without worsening AKI, in fact kidney function stabilizes or improves, only a temporizing measure.
Should #HFpEF be considered a pandemic nowadays. Almost everyone with dyspnea or 'air hunger', undergoes ECHO, and with normal EF, is being diagnosed with this diagnosis, especially elderly..., unfortunately even by some cardiologists? Seems like a default diagnosis.
@nature_sabine@drjohnm What long-term studies, unfortunately negative studies do not change practices where their are financial benefits. Did OAT, CARP, COURAGE & it's 15-yr follow up study, DANISH, ISCHEMIA & many more studies changed anything over past 2 decades.