It's another KRAS day at @CD_AACR! Three papers now online about mutant KRAS alleles, rewiring that occurs after allele-specific KRAS inhibition, and potential combination approaches - 2/3๐by William McDaid, Helen Adderley, Colin Lindsay, and colleagues @CRUK_MI@OfficialUoM
Very excited to share our first #KRAS paper published in Molecular Cancer (https://t.co/5RcdkNxE5o [https://t.co/SpZaQusvml]). We compared KRASG12C and G12D in driving #NSCLC tumorigenesis, seeing that G12D exhibits superior tumorigenicity, dependent on PI3K-AKT-mTOR signaling!