https://t.co/23ujvW2OjO
Did you know that sponges can move? @FabianRuperti with @savitski_lab and @Prevedel_lab studied sponge movement and found an evolutionary ancient mechanism controlling cellular tension and defense which is also present in our vasculature! A thread 🧵:
Happy to announce our new preprint on the ancestry of cell adhesion and self-recognition in animals! We used proteomics and structure-based searches to re-examine the Aggregation Factor from the classical sponge mode first studied by Henry Wilson in 1907! https://t.co/jeA7TUAAjo
Sponges lack muscles & neurons. Yet, they move. How?
EMBL Heidelberg Arendt Group @wormduty, @savitski_lab, @Prevedel_Lab & others, showed that sponge movement relies on an ancient relaxant-inflammatory response also found in vertebrate vascular systems.
https://t.co/JoQobxspiF
https://t.co/23ujvW2OjO
Did you know that sponges can move? @FabianRuperti with @savitski_lab and @Prevedel_lab studied sponge movement and found an evolutionary ancient mechanism controlling cellular tension and defense which is also present in our vasculature! A thread 🧵:
Many thanks to all the authors for this wonderful collaboration and additionally to:
-@SANICHOLS_DU and @diz_lab for the great feedback
-@althonos and @galicae for the support in python coding
-@itn_ignite and @embl EIPP for funding @FabianRuperti
https://t.co/23ujvW2OjO
Did you know that sponges can move? @FabianRuperti with @savitski_lab and @Prevedel_lab studied sponge movement and found an evolutionary ancient mechanism controlling cellular tension and defense which is also present in our vasculature! A thread 🧵:
The ocean 🌊 in us: The maintenance of laminar flow is essential for both - sponge canal and vertebrate vascular system Any deviation leads to the activation of this ancient conserved ‘relaxant-inflammatory’ response as a powerful defense reaction 🛡️.