The fact that bunnix has to witness one of her close friends falling apart more and more not being able to do anything because of interference w time so she just has to watch Maribug’s life spiral out of control from the burrow
Is the great favor Chapman did for Desmond, the use of his brain for experiments to produce mind-reading? Chapman is admitted to the neurosurgery floor. Maybe all the experiments got to him eventually and that's why he's dying?