Two people can be identical on paper, same weight, same insulin resistance, same fasting glucose, and the diet that improves one does nothing for the other. What separates them is not how resistant they are but which organ the resistance is strongest in.
A Dutch team ran the trial precision nutrition usually only promises: 242 adults, randomized, twelve weeks. They measured whether each person's insulin resistance sat in muscle or liver, then assigned two diets, high-monounsaturated-fat or low-fat/high-protein/high-fiber, so one group's pairing mirrored the other's. When the muscle-resistant people got the high-fiber diet and the liver-resistant people got the high-fat one, their insulin sensitivity, glucose control, triglycerides, and CRP all improved more than the reverse pairing. Same diets, same twelve weeks, same baseline resistance. The only difference was matching the diet to the tissue driving the problem.
The pre-registered primary outcome was null, so this lives in secondary markers, it's twelve weeks in adults with a BMI of 25 to 40, and the phenotyping needs a timed glucose tolerance test most clinics don't run.
Proof of concept, essentially. But it tests the actual premise the personalized-nutrition industry sells, that your biology should set your diet, with a real measurable readout instead of a genetic or microbiome guess. That's rare, and it's the version of that claim worth taking seriously.
Ben Wilson has advanced cancer. He has 4 small children. Please watch this video and see if you can help with medicine, introductions, or donations. He’s a good guy and a close friend. Please help in any way you can.
🚨🏴 𝗔𝗛𝗢𝗥𝗔 La Selección de Inglaterra tiene autorizado utilizar Viagra (Sildenafil) para usarlo contra México. El uso es completamente legal, con el objetivo de mitigar efectos de la altitud en el partido en el Estadio Azteca (2240 m), dilatar vasos sanguíneos y mejorar la oxigenación de los jugadores.
SHOCKING: Claude has a secret mode called "Research Accelerator."
It turns a 60-page paper into a literature review, a counterargument, and 10 research questions in under 5 minutes.
Here are the 13 prompts grad students are quietly using to finish in half the time:
Research found reduced blood flow to the brain's memory center, brain shrinkage in heavy users, and smaller brain volume linked to lifetime cannabis use.
Most people hear about relaxation. They don't hear the long-term cost.
The brain you'll have at 60 depends on the choices you make today. Protect it.
The older I get, the more I realize the world responds to clarity. Vague goals will get you vague results. The world will give you whatever you want, you just have to ask with clarity.
Instagram Head Adam Mosseri says growing alongside Mark Zuckerberg for 16+ years came down to one thing: "I wasn't very good. I just have a lot of range."
PhD Students - How to create a diagram in seconds?
1. Go to https://t.co/DtAQB3QKgr
2. Describe the diagram you want to create
3. ResearchViz will create the diagram
4. Edit it as per your need
5. Download it in any format you want
This quote from the @cognition CEO @ScottWu46 is one of the best I’ve seen about the age of AI, 💯:
“ We've been spending all this time living in Survival Mode as a species. Now we're going to be living in Creative Mode.”
BREAKING: EFCC Reportedly Uncovers $5 Billion, Alleged Future Election Results, ₦1 Trillion in Gold Necklaces, and 200 Exotic Cars During Raid on Theodore Orji's Umuahia Residence.
The raid was reportedly launched after the former Abia State governor allegedly failed to respond to several EFCC invitations and was said to have been in hiding for months.
"why is that the poorest part of this country are the Muslim's part?
Why is that in a state that started sharia in 1999 is not the most educated state in the country?"
~ Muhammadu Sanusi II, the Emir of Kano
Yoksul ailelerden gelen zeki çocuklar ilkokulda zengin akranlarıyla aynı başarıyı gösteriyor. Ancak ortaokula geçince motivasyonları düşüyor, psikolojileri bozuluyor ve nihayetinde okul başarıları da düşerek zengin akranları ile aralarındaki fark hızla açılıyor.