Howard Xue

Searcher and Researcher in Immunology Molecular Front

[Nature Immunology @NatImmunol]

Xue and colleagues find that Tle3 controls CD8+ TEM and CD8+ TCM cell fates and lineage plasticity via Runx3, Tcf1 and Tbet. Read it here: https://t.co/jYWHelrWR3

https://t.co/xdhL0iEAlA

[Howard Xue @Xuelab_IMF]

We thank Weiguo and colleagues for the nice summary of our recent work on #Tle3, https://t.co/Xc406xPuS6

[Hackensack Meridian School of Medicine @HMHSchoolofMed]

The Xue Lab at the Hackensack Meridian Center for Discovery and Innovation (CDI) has made another breakthrough in better understanding, and potentially modulating, the immune system to fight diseases. Dr. Howard Xue is also on SOM faculty!
Read more here:
https://t.co/lzkrlFHK4I

[Howard Xue @Xuelab_IMF]

#Tle3 a cool molecule that deserves some attention in immune cells. Key takeaways from https://t.co/Y8j0LJv0Dw 1) not just a corepressor, it can function as an coactivator, 2) an integrator of multiple TFs' actions, and 3) dynamically redistributed to meet functional needs.

[Howard Xue @Xuelab_IMF]

Pressing on with #Tle3 the transcriptional cofactor, which has unique roles in promoting effector memory but restraining central memory CD8 T cell formation. https://t.co/Y8j0LJv0Dw

[Howard Xue @Xuelab_IMF]

Groucho/TLE transcriptional cofactors do not bind DNA directly, but they could have cool functions by integrating many TF pathways. Proposed to study these in HSCs, LSCs, and T cells in 5 grants since 2020, no review panels discussed the proposals... Share the joy!!

[Howard Xue @Xuelab_IMF]

Groucho/TLE transcriptional cofactors do not bind DNA directly, but they could have cool functions by integrating many TF pathways. Proposed to study these in HSCs, LSCs, and T cells in 5 grants since 2020, no review panels discussed the proposals... Share the joy!!

[Howard Xue @Xuelab_IMF]

Adding the 3rd dimension to the enhanced recall capacity of memory T cells, our study reveals their unique chromatin architecture and CTCF binding patterns, which are distinctive from naive cells | PNAS https://t.co/6arYKqij2t

[Howard Xue @Xuelab_IMF]

Groucho/TLE transcriptional cofactors do not bind DNA directly, but they could have cool functions by integrating many TF pathways. Proposed to study these in HSCs, LSCs, and T cells in 5 grants since 2020, no review panels discussed the proposals... Share the joy!!

[Howard Xue @Xuelab_IMF]

@Zhang_Lab_UFL congrats weizhou!! need to learn from you how to write a winning grant

[Katalin Kariko @kkariko]

Nobel Prize winner Katalin Karikó was 'demoted 4 times' at her old job. How she persisted: 'You have to focus on what's next' https://t.co/6YplV89RE3

[Howard Xue @Xuelab_IMF]

Congrats @Mielke_Lisa on the outstanding new findings!! This excellent work highlights how important it is to study #Tcf1 in the right physiological or pathophysiological conditions!!

[Lisa Mielke @Mielke_Lisa]

Thrilled to share the first research story from my lab @ONJCRI published in @SciImmunology. A real team effort from all lab members, in particular @MarinaYakou @Sonia_Ghi Kelly Tran & Dinesh Raghu

https://t.co/l5cWxQsaCQ

[The Nobel Prize @NobelPrize]

“Ten years ago I was kicked out and forced to retire.”

Our new medicine laureate Katalin Karikó (@kkariko) told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges.

Ten years ago, Karikó was still doing all her experiments by hand but today she has been awarded the medicine prize for her research on mRNA, which led to the development of COVID-19 vaccines.

Listen now:

[Buitengebieden @buitengebieden]

Living the best life.. 😂

[Howard Xue @Xuelab_IMF]

Amazing new findings to our beloved versatile #Tcf1, which clearly has more up its sleeves. Congrats to Naomi and @golnaz_v team!!

[Golnaz Vahedi @golnaz_v]

Incredibly proud of a new study, led by brilliant Naomi Goldman, demonstrating for the first time that the intrinsically disordered domain of TCF-1 is critical for T cells. We are grateful to exceptional collaboration in @vahedilab and beyond
https://t.co/LZxCNFKbmr

[GRAS Lab @GrasLab]

🙏Thanks so much to @latrobe @LIMSLTU media teams for putting this together to highlight our work published @nature https://t.co/rHkdb5Vl98 and again well done to @LawtonMurdolo and @DimitraChatzil1 👏👏👏

[Howard Xue @Xuelab_IMF]

Win or let win with honor.

[Mohamad Safa @mhdksafa]

“In one of the most notable moments in sports history, Kenyan runner Abel Mutai was just a few feet from the finish line, but became confused with the signage and stopped thinking he had completed the race.

A Spanish athlete, Ivan Fernandez, was right behind him, and after realizing what was happening, he started shouting at the Kenyan for him to continue running; but Mutai didn't understand his Spanish.

Fernandez eventually caught up to him and instead of passing him, he pushed him to victory.

A journalist asked Ivan, "Why did you do that?"
Ivan replied, “My dream is that someday we can have a kind of community life where we push and help each other to win.” The journalist insisted “But why did you let the Kenyan win?" Ivan replied, "I didn't let him win, he was going to win.” The journalist insisted again, “But you could have won!”Ivan looked at him & replied, “But what would be the merit of my victory? What would be the honor of that medal?
What would my Mom think of that?”

Values are transmitted from generation to generation.

What values are we teaching our children?

Let us not teach our kids the wrong ways to WIN.”

Calltoactivism

[Howard Xue @Xuelab_IMF]

Thank you @Mielke_Lisa for being an amazing host. Appreciate @ASImmunology for this wonderful opportunity to meet so many fellow immunologists with shared interests.

[Lisa Mielke @Mielke_Lisa]

It was such a pleasure hosting @Xuelab_IMF as part of the @ASImmunology visiting speaker program. Exciting to hear about all the fabulous work on CD8 T cells coming out of the lab.

[Dorina Avram @dorina_avram]

Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8+ T cells https://t.co/PunUfXzCQi

[University of Iowa @uiowa]

Iowa City sunsets 🫶

[Howard Xue @Xuelab_IMF]

Why cytotoxic effector and memory precursor genes are regulated differently? Based on findings in our @JExpMed paper, one critical determinant is the chromatin architecture that they reside in, for CTCF to activate or to insulate. https://t.co/5SKG1W2lh2