Journal of Experimental Medicine

The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, neurobiology. Est. 1896 - @RockUPress

[Journal of Experimental Medicine @JExpMed]

Oral antigen exposure under co-stimulation blockade induces Treg cells to establish immune #tolerance. From Masaya Arai, Ryoji Kawakami, Shimon Sakaguchi and colleagues: https://t.co/xlKpHSt52v

Part of our Immune #Tolerance collection 👉 https://t.co/Aoc4rniiWo

[Journal of Experimental Medicine @JExpMed]

New study from Danping Wei, Guangzhe Ge, Chih-Yuan Chiang, Yaqiang Cao et al. from the Jinfang Zhu lab (NIAID) identifies key transcriptional regulators of Th2 #cytokines through a CRISPR-based screen. https://t.co/FpR0p91P4h

[Journal of Experimental Medicine @JExpMed]

Chimeric MHC class I and II-restricted non-self epitopes broaden anti-tumor T cell reactions. From Rongsheng Zhang, Tasuku Honjo, Kenji Chamoto and colleagues: https://t.co/KRTCQ0u3po

Part of our Immune #Tolerance collection 👉 https://t.co/paEMEuIJMX

[Journal of Experimental Medicine @JExpMed]

#Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central #tolerance. From Jiří Březina, Dominik Filipp and colleagues @CzechAcademy: https://t.co/Qie6Ase1eJ

Part of our Immune #Tolerance collection 👉 https://t.co/jHy1YEOBZs

[Addie Walsh @Addie_E_Walsh]

My first-author paper is now live @JExpMed! We found that the Alzheimer's disease risk factor CASS4 is a critical regulator of amyloid beta plaque compaction, microglial mobilization to damage, and focal adhesion signaling.
https://t.co/ZiR1fbd6Xf

[John Lukens @LukensJohnR]

New study from our group @Addie_E_Walsh 👇
Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis @JExpMed https://t.co/v6woVm7AYG #Alzheimer

[Journal of Experimental Medicine @JExpMed]

@LukensJohnR 📽️ See a short video summary by the first author, Adeline E. Walsh: https://t.co/i1x4J8Qxsv

[Journal of Experimental Medicine @JExpMed]

CASS4 is a genetic risk factor for #Alzheimers disease but remains understudied in the brain. Walsh, @LukensJohnR et al. identify CASS4 as a critical regulator of amyloid β plaque compaction, microglial mobilization to damage, & focal adhesion signaling. https://t.co/12MBCGw3bO

[Journal of Experimental Medicine @JExpMed]

See the accompanying Press Release: https://t.co/LHbna7zygo

[Journal of Experimental Medicine @JExpMed]

Ai-Ping Cao, Jun-Cheng Li, Rui Wang et al. reveal that the Vanin-pantethine-cholesterol axis acts as a metabolic checkpoint controlling #DendriticCell activation in autoimmune #inflammation. https://t.co/BcfquMnsKA

#Autoimmunity #Psoriasis

[Journal of Experimental Medicine @JExpMed]

📰 #PressRelease: Researchers have discovered that the vitamin derivative pantethine prevents the development of #psoriasis in mice and helps alleviate patient symptoms in a small-scale human trial. https://t.co/xiwqt0x64o

See the original JEM study: https://t.co/33Jynkf8u7

[Journal of Experimental Medicine @JExpMed]

DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. From Emily Siniscalco, Courtney Fisher, Meng-Ping Lu, Stephanie Eisenbarth, Uthaman Gowthaman and colleagues: https://t.co/5xLtfk2P5S

Part of our Immune #Tolerance collection 👉 https://t.co/HPZq1n3n7X

[Journal of Experimental Medicine @JExpMed]

Targeting Mettl8-Tcf1 axis promotes CD8⁺ TPEX differentiation and antitumor immunity. From Jiaxi Song, Dan Cui, Qizhao Huang, Jia Li, Fengyin Li, and colleagues: https://t.co/XeOeUnL4Lg

Part of our Immune #Tolerance collection 👉 https://t.co/9EzH5KZigI

[DeZio_Lab @melanomateam]

Thrilled to share our new Review on how to make a cold tumor hot, published in the Journal of Experimental Medicine @RockUPress
https://t.co/gkYFBKEGAz

[Journal of Experimental Medicine @JExpMed]

Marwa Saad, Angelina Bilate, Daniel Mucida et al. @RockefellerUniv show that colorectal tumors with distinct metastatic potential trigger divergent early T cell responses. https://t.co/WqmHWfAAWX

#SolidTumors #MucosalImmunology #TumorImmunology #ColonCancer #TCells

[Journal of Experimental Medicine @JExpMed]

Inhibitory receptor agonists: Emerging strategies in immune modulation. Review from Kieran R. Adam, Aamir Suhail, Vijay K. Kuchroo, and Dario A.A. Vignali: https://t.co/DnenAAmtRQ

Part of our Immune #Tolerance collection 👉 https://t.co/8rOg3ICCsA

[Journal of Experimental Medicine @JExpMed]

B7 costimulation antagonizes RORγt+ regulatory #Tcells and immune #tolerance in the intestine. From Mengze Lyu and Gregory F. Sonnenberg: https://t.co/mG4gvIKMzP

Part of our Immune #Tolerance collection 👉 https://t.co/7MJnGL28DB

[Journal of Experimental Medicine @JExpMed]

IgD from atypical-like memory #Bcells and #plasmacells targets commensal and environmental antigens. By @RoserTP, @HabibBashour, Filipska et al. (@victorgreiff & Cerutti labs): https://t.co/88MKuPAy6s

Part of our Immune #Tolerance collection 👉 https://t.co/m38yKqfkhK

[Journal of Experimental Medicine @JExpMed]

PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity. From Shibo Liu, Guanghao Liang, Yayun Yang, Yanyang Shi, Lihui Dong, Peng R. Chen, Meng Michelle Xu et al. https://t.co/90DwS4hixQ

Part of our Immune #Tolerance collection 👉 https://t.co/o0Wusoed3Z

[Journal of Experimental Medicine @JExpMed]

Regulatory T cells sabotage anti-tumor γδ #Tcells by creating IL-2–deficient environments. From @RafaelBlancoDom, @BSilva_Santos, Sofia Mensurado and colleagues: https://t.co/x8z2YOu31S

Part of our Immune #Tolerance collection 👉 https://t.co/5zyMMb0ACI