Yolanda Combrinck

Hard work + Dreams + Dedication = Success! MPharm candidate @SMUClinPharm with an interest in TDM of Antiepileptics

[Sonya kolman @Sonya_kolman]

If we test without intepreting then yes is a waste but if we intepret them effectively then is a crucial aspect of #clinpharm @sasocp https://t.co/Bm5PcqG4uf

[Michelle Gijzelaar @michellegijzel1]

@sasocp Although not taking samples correctly or not doing anything with the drug level information obtained is a waste #clinpharm @sasocp

[Halima @halimaismail205]

@sasocp @Sonya_kolman I think in paeds TDM is important, because of the increase in VD and the low hepatic and renal function.

[Yolanda Combrinck @ycombrinck1]

Incredibly important!! @sasocp #clinpharm https://t.co/zr5XsThEEe

[SASOCP @sasocp]

Especially if you have patients with hepatic impairment. Important especially with #HAART. #clinpharm https://t.co/PxpfAR9OIz

[SASOCP @sasocp]

Important in especially cardiac patients. Digoxin very narrow therapeutic index and very toxic #clinpharm https://t.co/gdAlT3XHEK

[SASOCP @sasocp]

Practice practice practice - and use resources. Important to know drug characteristics #lipohilic, #hydrophilic, as well as half life etc. #clinpharm https://t.co/TfkYmdjJj3

[SASOCP @sasocp]

Any ideas on monitoring of obese patients? Do you have a guide to dose in #obesity? #clinpharm

[SASOCP @sasocp]

Another important aspect of TDM timing is to know when drug reached steady state - 3-5 half lives #clinpharm @sasocp

[Yolanda Combrinck @ycombrinck1]

Absolutely!! Extremely important!!! @sasocp #clinpharm https://t.co/IntJbrEeNu

[SASOCP @sasocp]

Another important aspect of TDM timing is to know when drug reached steady state - 3-5 half lives #clinpharm @sasocp

[SASOCP @sasocp]

What about patients on Renal Replacement Therapy? Are they monitored more closely? Cool diagram for patients on RTT

[Yolanda Combrinck @ycombrinck1]

This is great!! @sasocp #clinpharm https://t.co/ToTcHsNnFO

[SASOCP @sasocp]

What about patients on Renal Replacement Therapy? Are they monitored more closely? Cool diagram for patients on RTT

[SASOCP @sasocp]

The pharmacist may assist in taking samples at the correct times. Do you know which tubes are appropriate for TDM samples?

[Yolanda Combrinck @ycombrinck1]

This is great!!! @sasocp #clinpharm https://t.co/otu0klloD1

[SASOCP @sasocp]

The pharmacist may assist in taking samples at the correct times. Do you know which tubes are appropriate for TDM samples?

[Michelle Gijzelaar @michellegijzel1]

👍If we need to use our precious antimicrobials, best we ensure appropriate dosing otherwise:treatment failure and ⬆️resistance #clinpharm https://t.co/cPiGQBqkL6

[SASOCP @sasocp]

New trend in TDM in B-lactams matches Drugs, Bugs and Mugs - the host plays a role in individualized antimicrobial therapy #clinpharm https://t.co/6jxnqetIKv

[SASOCP @sasocp]

The correct timing of a serum sample is crucial to the interpretation of the result #clinpharm

[SASOCP @sasocp]

Absolutely! #clinpharm going strong! https://t.co/1rjQyk1IrQ

[Lucille Crafford @LucilleMalan]

Don't think enough yet, there is still significant variability among institutions with respect to the practice of TDM, incl selection of PK/PD targets as well as dose optimisation strategies #clinpharm @sasocp https://t.co/VUMKh9ziHv