Yesha

Postdoc, Helmann lab, Cornell University

[Gopal Chovatiya @Chovatiya_Gopal]

Super excited and proud to share our work on cell-type-specific nascent transcriptomics in vivo by PReCIS-seq. Interested in learning about the early steps of gene regulation by RNA Pol II in specific cell types within intact mouse tissue? A thread below.
https://t.co/qlUaNO69lp

[Yesha @Yesha_SP]

@Aisha_Burton Congratulations!!

[Yesha @Yesha_SP]

@kathayat_dipak Congratulations!!

[Yesha @Yesha_SP]

@SaadleeS Congratulations!!

[John D. Helmann @JohnHelmann]

The yqgCsodA operon plays a significant role in Mn homeostasis. How the YqgC membrane protein helps protect cells is one (of several) mysteries!

The Bacillus subtilis yqgC-sodA operon protects magnesium-dependent enzymes by supporting manganese efflux https://t.co/PLnvxSAskF

[John D. Helmann @JohnHelmann]

More cell membrane puzzles to solve...
[from @JessicaWilldigg and @Yesha_SP]

The Bacillus subtilis cell envelope stress-inducible ytpAB operon modulates membrane properties and contributes to bacitracin resistance | Journal of Bacteriology https://t.co/PwdPdZCMUJ

[John D. Helmann @JohnHelmann]

Bacterial cells struggling to make enough peptidoglycan to support growth can be phenotypically rescued by mutations down-regulating fatty acid/membrane synthesis...or even by the antibiotic cerulenin...

[from @JessicaWilldigg and @Yesha_SP].
https://t.co/0sdKP81clS

[John D. Helmann @JohnHelmann]

This study [from @JessicaWilldigg,
@Yesha_SP and collaborators from the Rock lab] identifies new genes involves in bacterial membrane physiology. These genes have striking effects on homeoviscous adaptation and impact resistance to the antibiotic bacitracin.

[John D. Helmann @JohnHelmann]

How can cells control the metalation of exported proteins? Here, we provide evidence that TerC proteins function in the co-translocational metalation of exoenyzymes with Mn. In their absence, translocon jamming impairs protein secretion.

https://t.co/M5Ol2ITvrk

[John D. Helmann @JohnHelmann]

Applications due SEPT. 10 for 2 yr post-doc. fellowships through Cornell Institute of Host-Microbe Interactions (CIHMID).
The Helmann lab is happy to (co)sponsor applicants.

Please email to discuss possible projects.
https://t.co/FJ7Lpjd3Lz
(US citizens/residents eligible)

[Yesha @Yesha_SP]

An excellent opportunity for bacterial geneticists!!

[John D. Helmann @JohnHelmann]

Postdoc Position! In the Helmann lab at Cornell U, working on molecular genetics of B. subtilis stress responses, with a focus on metal ion homeostasis & cell envelope stress responses.
Submit a CV & statement of research interests to jdh9(at)https://t.co/kWLAVbO3Oq.

[Yesha @Yesha_SP]

@CHSteingard @CornellOISE @CornellGrad Congratulations, Caroline!

[George O'Toole (he/him/his) @GeiselBiofilm]

Postdoc Position! In the Helmann lab at Cornell U, working on molecular genetics of B. subtilis stress responses, with a focus on metal ion homeostasis & cell envelope stress responses. Submit a CV & statement of research interests to jdh9(at)https://t.co/lMXJmFtsxY. Pls share

[Gopal Chovatiya @Chovatiya_Gopal]

Opportunity not be missed - for those interested in employing genomics and functional approaches in tissue stem cell biology.
Amazing mentor and beautiful place to live in!
Can vouch from personal experience.

[Doina Tumbar @DoinaTumbar]

Technician III research position in the Tumbar laboratory of tissue stem cells at Cornell University in Ithaca, NY using genetic and genomic approaches. This 1-2 years NIH funded position is an excellent opportunity to gain research experience. Qualification: Bachelor in biology.

[Doina Tumbar @DoinaTumbar]

Postdoctoral associate position NIH funded available in the Tumbar Lab at Cornell University in Ithaca to study molecular mechanisms of tissue stem cell function using genomic and genetic approaches. Qualifications: PhD in cell and developmental biology or related area.

[John D. Helmann @JohnHelmann]

Cytosolic enzymes acquire metal cofactors from buffered pools. But how are extracellular enzymes properly metalated?
Mn-enzymes can be co-translocationally metalated by TerC.

TerC Proteins Function During Protein Secretion to Metalate Exoenzymes https://t.co/EOPUIzpMfq

[John D. Helmann @JohnHelmann]

Genetic and chemical rescue experiments show that in Bacillus subtilis...

A decrease in fatty acid synthesis rescues cells with limited peptidoglycan synthesis capacity
https://t.co/0sdKP80Ewk

from @JessicaWilldigg and @Yesha_SP.

[John D. Helmann @JohnHelmann]

A model industrial workhorse: Bacillus subtilis strain 168 and its genome after a quarter of a century
https://t.co/30XBIcZTrA

Led by the inimitable Antoine Danchin: bioinformatics pioneer, instigator of genome sequencing, and biological philosopher!
https://t.co/L8H8aHAHmK